ABOUT EPPENDORF
Let’s Bioprocess Together
At Eppendorf, our aim is to empower you on your upstream bioprocess journey. We provide trusted and innovative bioprocess solutions to develop cell culture and fermentation bioprocesses and move them from R&D to production. We have orchestrated our scalable bioprocess systems, single-use bioreactors, software solutions, and services to optimize process control, automate routine tasks, and harness the power of data. We listen to your specific challenges and work together with you to solve them. The bottom line is more speed, less risk, and more success in your business.
Our purpose is to help bring life-saving treatments to the world. With our bioprocess solutions and in line with our corporate mission, we contribute to the efforts of Eppendorf customers worldwide to improve human living conditions.
Since 1945, the Eppendorf brand has been synonymous with customer-oriented processes and innovative products, such as laboratory devices and consumables for liquid handling, cell handling and sample handling. Today, Eppendorf and its more than 5000 employees serve as experts and advisors, using their unique knowledge and experience to support laboratories and research institutions around the world.
VIDEOS/WEBINARS
Discover how integrated solutions create a harmonious bioprocess ecosystem. Learn about data integration, digital technologies, and automation to streamline your lab workflow and drive innovation.
Discover how to optimize iPSC culture conditions for significant cell number increases while preserving stem cell features.
Stirred-tank bioreactors have emerged in recent years as the optimal platform to optimize (stem) cell culturing raising their potential in the cell and gene therapy industry.
A next-generation bioprocess control station, designed as a universal platform capable of meeting the ever changing needs of all segments of the biotech and pharmaceutical sciences.
This mini bioreactor system is a premium tool that helps streamlining process development.
This webcast reviews a research example for process development with the human tumor cell line H157, cultivated in stirred-tank mini bioreactors as 3D cell aggregates.
FEATURED CONTENT
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![Eppendorf- Single-Use-Bioreactors_Family]( "The Advantages Of Single-Use Bioreactors")
Reduce the time and risks involved in maintaining a traditional bioreactor with this single-use solution for biopharmaceutical manufacturers.
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![Regenerative medicine and therapeutic stem cell therapy GettyImages-1334489810]( "Optimizing Cell And Gene Therapy Workflows")
Explore the growing field of cell and gene therapies along with a bioreactor system that is enabling researchers to expedite cell culture development and optimize their research time.
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![GettyImages-1449007950-tumor-cancer-t-cell]( "A Beginner's Guide To Cell Therapy Bioprocessing")
Take a deeper look into innovative solutions for researchers facing challenges throughout the development of novel cell and gene therapeutics.
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![Eppendorf people-scene_BioFlo-720_man-using-touchscreen-2 - CMYK]( "Are Bioreactors The New 'Fish Tanks'?")
By exploring innovative approaches to scaling up animal cell growth in cutting-edge bioreactor systems, foodtech companies are poised to offer healthier, safer, more sustainable fish for consumers.
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![PLASMID PURIFICATION - GettyImages-664695674]( "Key Factors For Successful Plasmid Production")
Review the distinct steps in the plasmid production workflow, along with tips for optimization from vector and strain selection to cultivation and beyond.
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![Gene therapy iStock-1249306244]( "Advances In Bioprocessing For Biologics And Gene Therapy Vectors")
This article collection highlights the importance of continued research and development in the field of bioprocessing to revolutionize the next generation of therapies and personalized medicine.
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![iStock-1221576332-cell]( "Inline Monitoring Of hiPSC Growth And Differentiation")
Explore a study demonstrating the use of dielectric spectroscopy tools for monitoring expansion and differentiation of hiPSC aggregates in stirred-tank bioreactors.
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![Eppendorf- cell-culture-efficiency]( "Increasing The Reproducibility Of Cell Culture Bioprocesses")
Explore the question of how to keep bioprocess conditions consistent between different runs and receive expert tips on maintaining complex culturing conditions and parameters.
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![Exosomes GettyImages-1078208498]( "Cell & Gene Therapy Insights From An Expert")
Application scientist, Dr. Jorge Escobar Ivirico, explains and underscores the key differences with the production of exosomes from other cellular therapies.
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![Bioanalytical & ADME Laboratory Services]( "What You Need To Know Before Investing In A Bioprocessing Space")
Selecting the bioreactor that is best for your process and the dedicated space you have available requires consideration of many important factors.
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![DASbox Mini Bioreactors System]( "Bioreactors And Fermentors: Tools For Resolving Cultivation Bottlenecks")
In this white paper we explain the key characteristics of stirred-tank bioreactors and which organisms are typically grown in them.
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![Bioprocess Pipette]( "Scalable Production Of AAV Vectors")
This article examines some of the currently available schemes used in generating rAAV from suspension cultures, and describes what it takes to achieve scalable rAAV production.
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![Controlled Cultivation of Stem Cells – Factors to Consider When Thinking of Scale-Up]( "Controlled Cultivation of Stem Cells – Factors to Consider When Thinking of Scale-Up")
Great hopes and expectations are linked to stem cells as a tool for drug discovery and to stem cell-derived products in therapeutic applications. Though several products have made it to commercial stage, most of the research is still performed in small scales using simple cultivation systems such as spinner flasks or T-flasks.
CONTACT INFORMATION
Eppendorf SE
Bioprocess Center, Rudolf-Schulten-Straße 5
Jülich, 52428
GERMANY
PRODUCTS
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![SciVario-front-cell-culture]( "SciVario® twin Bioprocess Controller")
The SciVario twin is a future proof bioprocess controller, developed by Eppendorf, with the intuitive software, bringing the digital age to the laboratory.
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![BioFlo 320 Bioprocess Control Station]( "BioFlo® 320 Bioprocess Control Station")
Whether your process includes cell culture or fermentation, autoclavable or single-use vessels, the BioFlo 320 seamlessly combines form and function in one state of the art package. A robust industrial design, intelligent sensors, Ethernet connectivity, and enhanced software capabilities are only a few of the features that set it apart from the competition. Combined with a sincere commitment to quality, the BioFlo 320 truly is the premium choice in bench-scale bioprocess control stations.
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![BioBLUcandp]( "Single-Use Vessels For Cell Culture")
Combine the benefits of single-use bioreactor technology with the reliable performance of conventional glass or stainless steel bioreactors – Discover the Eppendorf BioBLU product line.
BROCHURES
APPLICATION NOTES
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![GettyImages-637368252 Scientist Monitoring Equipment Readings, CQV Concept]( "Biocompatibility Studies On CHO Cell Culture In X-ray Irradiated BioBLU® Single-Use Bioreactors")
In cell culture, the leakage of toxic or inhibitory chemicals from single-use bioreactors has become a growing concern. Explore recommendations for leachable studies.
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![GettyImages-1327318287 cells]( "Human Induced Pluripotent Stem Cell Aggregate Expansion In Stirred-Tank Bioreactors Using SciVario<sup>® </sup>Twin Bioprocess Controller")
Learn about a bioreactor-based Human Induced Pluripotent Stem Cell expansion workflow with the potential to improve cell therapy applications.
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![Scientists laboratory thinking GettyImages-1206395543]( "Achieve Fast And Efficient Isolation Of Exosomes From Stem Cells")
Review this demonstration of a bioreactor and bioreactor system combination used to isolate exosomes after culturing human adipose-derived stem cells in suspension on microcarriers.
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![GettyImages-1288118586 cell development]( "Increasing iPSC Numbers Through Systematic Culture Process Optimization")
Explore the use of a mini bioreactor system for stem cell culturing that optimized process parameters of a human induced pluripotent stem cell (hiPSC) culture in a step-by-step process.
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![Cell research GettyImages-879831370]( "CHO Culture: Bioprocess Modes Batch Fed-Batch and Perfusion")
Explore the differences between three cell culture bioprocesses using bench-scale CHO cells, and why tracking specific parameters is important to achieving the inoculation of bioreactors at high viability.
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![Eppendorf SciVario and BioBLU]( "Maximize Adeno-Associated Virus Production Using Suspension Culture")
Review this example of scalable AAV production on a suspension cell culture platform through the AAV-2 capsid production process in a controlled environment.
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![450x300-image-lymphocytes]( "How To Best Optimize CD4 T Cells Expansion")
Learn how stirred-tank bioreactors can be used to efficiently expand T cells from different donors.
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![Eppendorf]( "E. Coli Plasmid DNA Production")
Explore the feasibility of plasmid DNA production using the DASbox Mini Bioreactor System and compare fed-batch with batch culture with respect to plasmid DNA yield and process efficiency.
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![Exosomes GettyImages-1078208498]( "A Tool For Process Development, Stem-Cell Derived Exosome Production")
This study reviews a fully controlled system allowing an expansion of a high yield of viable cells and optimizing production of high-quality extracellular vesicles in standardized culture conditions.
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![Eppendorf MSC exosome production using the SciVario twin bioreactor]( "Stem Cell Exosome Production On The SciVario® Twin")
In this app note, we monitored and analyzed the metabolites derived from hiPSCs as well as cell adhesion and morphology, suggesting that we obtained an excellent physiological environment over time.
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![Transient Lentiviral Vector Production]( "Transient Lentiviral Vector Production In HEK 293T Cells Using The BioFlo 320 Control Station With A BioBLU 5p Single-Use Packed-Bed Vessel")
Current bottlenecks in the production of LVs are caused mainly by the disadvantages of classical two-dimensional culture forms. Switching to bioreactors can eliminate those disadvantages and offer the benefits of process automation, tight regulation of production conditions, and reduced labor input.
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![Eppendorf 1]( "Controlled, Large-Scale Manufacturing Of hiPSC-Derived Cardiomyocytes In Stirred-Tank Bioreactors")
Effective drug discovery and development relies in large part on the availability of predictive preclinical model systems. Learn about a bioprocess for the large-scale manufacturing of cardiomyocytes derived from a variety of healthy and diseased hiPSC lines.
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![DASbox Mini Bioreactor System]( "Production Of Human iPSC-Derived Cortical Neurospheres In A Mini Bioreactor System")
Stem cell-derived cortical neurospheres are of great interest in basic neurobiology research and drug research. Cultivation in controlled, stirred-tank bioreactors can improve the homogeneity of neural spheroid cultures and allows culture scale-up.
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![Cell]( "Billion-Cell Hypoxic Expansion Of Human Mesenchymal Stem Cells In BioBLU® 5c Single-Use Vessels")
In this study, we successfully demonstrated large-scale culture of human adipose-derived mesenchymal stem cells (AdMSCs) in an industrial, single-use vessel at 3.75 L scale and demonstrate the fact that the process can be conveniently scaled up to industrial levels of production without having to rely on stainless steel culture facilities.
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![DASBox.jpg]( "Scalable Expansion Of Human Pluripotent Stem Cells")
The routine application of human pluripotent stem cells and their derivatives in regenerative medicine and innovative drug discovery will require the constant supply of high cell numbers in consistent, high quality.
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![Culture Of 3D Cell Aggregates In Perfusion In A DASbox Mini Bioreactor System]( "Culture Of 3D Cell Aggregates In Perfusion In A Mini Bioreactor System")
These promising culture systems allow efficient establishment and maintenance of cell aggregates, process monitoring and control, and process scale-up to larger volumes.
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![Expansion Of Human Bone Marrow-Derived Mesenchymal Stem Cells In BioBLU 0.3c Single-Use Bioreactors]( "Expansion Of Human Bone Marrow-Derived Mesenchymal Stem Cells In Single-Use Bioreactors")
This application note details the suitability of Eppendorf BioBLU 0.3c Single-Use Vessels controlled by a DASbox Mini Bioreactor System for the expansion of human bone marrow-derived mesenchymal stem cells on microcarriers.
