CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Developing And Validating Clinical Receptor Occupancy Pharmacodynamic Biomarker Assays

  Receptor occupancy (RO) assays assess drug-target engagement and support PK/PD modeling. Accurate RO requires customized assays using stabilized blood to monitor CD6 modulation in autoimmune therapy.

• Aseptic Filling Solution Enhances Sterility Assurance for Pharma Manufacturer

  Emergent BioSolutions upgraded its Winnipeg site with the Cytiva SA25 aseptic filling workcell to improve sterility assurance, product flexibility, and regulatory compliance for CGT manufacturing.

• Improving Formulation And Aliquoting Efficiency With Mixing Solutions

  Separate formulation, filtration and aliquoting add transfers and integrity tests. A single closed flowpath can improve time, yield and contamination control.

• Scaling Investigational Drug Services: A Case Study in Overcoming Operational Bottlenecks

  Are operational bottlenecks holding back your research site? Explore a blueprint for automating investigational product workflows and giving staff time back for patient care.

• How Blast Freezing Affects The Quality Of Bottled Drug Substance: Test Results And Insights

  Uneven ice formation during bottle freezing creates a "Volcano Effect," pushing solutes into highly concentrated zones. This test-based study explains this risk to drug substance quality.

• A Temperature-Stable Replacement For Animal Trypsin In Cell Dissociation Applications

  Improve cell dissociation with a gentle, recombinant enzyme. This temperature-stable protease shows dissociation kinetics similar to porcine trypsin but with lower cell toxicity and greater overall purity.

• High-Yield Cell Therapy Bioproduction

  Producing billions of dental pulp stem cells strains static culture and complicates harvest. A closed planar perfusion approach offers another route, with scale-up lessons from one developer.

• AAV Viral Titering Using Nanoplate-Based Digital PCR

  Examine how nanoplate-based digital PCR streamlines AAV titering, providing faster results and greater accuracy, advancing gene therapy development from the lab to the clinic.

• Optimized Product Recovery Using The Drug Product Filtration System

  Explore strategies to maximize drug product recovery during sterile filtration, minimize hold-up volume, and reduce dilution after PUPSIT to ensure higher yield, improved efficiency, and less waste.

• Flexible Multiplex Solution For VCN Determination In Gamma-Retrovirus–Transduced CAR-T Cells Using QIAcuity® dPCR

  See how a multiplex digital PCR approach enables accurate, reproducible VCN determination in gamma‑retrovirus–transduced CAR‑T cells, supporting streamlined workflows and confident decision‑making.