CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Formulation Development Of Enterically Protected Spray Dried Dispersions

  Adrulipase spray-dried dispersions were evaluated to create an orally delivered, enteric-protected enzyme. The lead formulation provided the best acid protection, rapid release, and stability.

• A High-Throughput Platform For Fast And Reliable Clone Screening

  The Cydem VT platform consists of several technologies allowing for the cultivation and monitoring of CHO cells in cell line development. Find out how to set up your experiment on this device.

• Annex 1: Sterile Fill/Finish For Early Phase Clinical Supplies

  Meeting stringent requirements for sterile fill/finish operations hinges on robust contamination control strategies, advanced isolator technology, and rigorous integrity testing to ensure patient safety.

• Adapting Single-Use Chromatography To Manufacturing Scale

  Explore strategies for accommodating the ever-increasing upstream titers and volumes to prevent downstream purification from becoming a bottleneck.

• Sterilizing Grade Filter Performance With Biologic Drugs

  Examine the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins as well as how filter selection can impact your process.

• Cell Collection Basics For The Transplant And CGT Industries

  Breakthroughs in CAR T-cell and stem cell therapies depend on mastering cellular collection. Understanding these fundamentals is vital for advancing treatment efficacy and patient outcomes.

• Enhanced mAb Production With High-Intensity Perfusion CHO Medium

  Reach new heights in mAb production with a high-intensity perfusion CHO medium designed to support consistently high product yield and quality in continuous perfusion cultures using CHO-K1 cells.

• Scale-Up Approaches For Culturing Adherent Cells

  For successful scale-up, see how optimizing process parameters such as attachment methods, gassing, and agitation can help reduce cell environmental stress, ultimately improving productivity.

• Assessment Of Compound Toxicity Effects With High-Content Imaging

  3D cellular models and bioprinting enhance drug safety predictions and offer precise spatial control. Explore an automated method for generating liver models to improve reproducibility and reliability in toxicity testing.

• The Importance Of Quality Proteins For Research, Development, And Manufacturing

  Learn how validated testing, strict sourcing, and regulatory guidance help minimize endotoxin contamination risks and support reliable therapeutic development in advanced medicinal products.