CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Challenges, Methods, And Solutions For Obtaining Optimal Starting Material

  For innovative treatments like CAR-T and stem cell transplants, optimal starting material is key. Understanding collection challenges and new solutions helps ensure the best foundation for these therapies.

• Monitoring Microbial Contamination Of Mammalian Cell Cultures

  Mammalian cells are widely used to produce complex processed molecules. Explore a system that effectively detects microbial contamination in mammalian cell cultures and utilizes a newly formulated lysis buffer.

• 12-Day Stability Of PRIME-XV T Cell Expansion Supplemented With CTGrade GMP Cytokines

  Discover how T-cell culture media supplemented with key cytokines can maintain full functionality and support robust expansion for up to 12 days at room temperature.

• Levers To Optimize The IVT Reaction For Increased mRNA Yield

  Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.

• Cell Retention Technology And Specialized Cell Culture Media

  Explore how perfusion technology is transforming upstream bioprocessing by boosting productivity, reducing costs, and enabling process intensification while overcoming cell retention challenges.

• Efficient Clone Screening With Increased Process Control And Integrated Cell Health And Titer Measurements With The Cydem VT Automated Clone Screening System

  Automated screening of antibody-producing clones provides real-time cell health and titer data, helping developers identify top-performing candidates earlier and with confidence.

• The Case For Non-Viral Circular Single-Stranded HDR Donors

  Enable efficient, low-toxicity genome editing without viral vectors. This cell-free circular ssDNA platform preserves stem cell fitness while supporting scalable manufacturing.

• Preventive Control Of Sequencing Through The Insert

  Understanding library size distributions helps prevent sequencing through the insert, reducing adapter read‑through. Explore how smear analysis guides optimal read‑length selection to avoid noise.

• Faster, Cheaper Cell Therapy with At‑Line QC

  Automated at‑line immunophenotyping QC streamlines cell therapy manufacturing, cutting turnaround time and cost while aligning with conventional methods and enabling scalable, reliable workflows.

• Redefining The Analytical Frameworks Surrounding Capsid Characterization

  Modern AAV manufacturing demands precise capsid characterization to distinguish empty, partial, and full particles, as regulators now require rigorous purity and potency control for clinical safety.