mRNA medicines represent the genesis of a fourth pillar of pharma innovation. While exciting, there are several critical challenges we must solve to strengthen this pillar, including stability and deliverability.
- Inside BlueRock Therapeutics' Parkinson's Disease Trial with Dr. Ahmed Enayetallah
- NK Cell Therapies: How Artiva Biotherapeutics Leverages Its “Manufacturing First” Approach
- Improving Governance And Compliance With Knowledge Management
- China’s Rising Role On The Global Stage In The Oncology Market
- GMP Plant Uniform Lockers And Procedures: Best Practices
- A Deeper Look At What's Driving Dependence On Biotech Contract Manufacturers
- Developing A Process Performance Qualification Master Plan For Gene Therapies
- What Time Is Best To Bring My CDMO On Board?
CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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Generation And Preclinical Applications Of Humanized Mouse Models
Here, we show an automated experimental setup for human CD34+ HSC enrichment from umbilical cord blood for the successful generation of humanized mouse models.
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Perspectives On The Adoption Of Fully Closed Processing
In this study, industry experts share their perspectives and plans related to the implementation of fully closed processing. Explore the drivers and challenges of fully closed processing and more.
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mRNA-LNP Nucleic Acid Assessment From Distinct Formulations
Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.
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Solution For Serum-Free Cryopreservation Of Primary Cells And Tumors
Explore the performance of a chemically defined, serum-free, and animal component–free freezing solution in the cryopreservation of peripheral blood mononuclear cells (PBMCs), mouse tumors, and tumor cell suspensions.
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A Complete Macrophage Suppression Assay Workflow
Analyze an experiment conducted to validate a macrophage suppression assay workflow and demonstrate a consistent in vitro macrophage suppression assay used in the validation process.
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Targeting Macular Degeneration With Stem Cell Therapy
A novel stem-cell therapy based upon iPSC-derived RPE cell transplantation was conceptualized as a promising new treatment for AMD and other retinal diseases.
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Get Full Control Of Your T Cell Isolation
This study demonstrates the automated magnetic isolation of CD4/CD8+ cells from fresh or frozen leukapheresis using a functionally closed cell processing system paired with a modular application.
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Dissociation Of Tumor Tissue Samples For Single-Cell Genomics
For this study, solid tumors from syngeneic mouse models were collected and preserved in MACS® Tissue Storage Solution, then dissociated using the gentleMACS™ Octo Dissociator with Heaters and the Tumor Dissociation Kit mouse.
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A Mammalian Suspension Technology For Scalable rAAV Production
Explore a HEK293 derived animal component-free suspension cell line as the foundation of an up to 2000-liters scalable and robust platform process that increases the speed of AAV manufacturing.
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Cell Harvesting: Optimizing Viability And Recovery In Cell Therapy
Learn about a family of centrifuges and review of data collected on the centrifuges' performance for the harvest of cells in cell therapy production.
NEWSLETTER ARCHIVE
- 04.25.24 -- Insights From Across The Globe: Trends In Clinical Trials
- 04.25.24 -- Reducing The Disease Burden Of AML With Vor Bio's Dr. Robert Ang
- 04.24.24 -- Outsourcing Best Practices To Increase Efficiency And Compliance
- 04.24.24 -- Cell Counting Is Growing More Important Amid Advanced Therapy's Rise
- 04.23.24 -- Inside Tenaya Therapeutics' AAV9-Based Gene Therapy
CELL AND GENE CONTENT COLLECTIONS
While there are opportunities to scale, there are also manufacturing gaps, capacity issues, and production timelines that require improvement to do so. And then, of course, there’s cost. Because scale up and scale out are significant to everyone in the sector, we’ve curated insightful editorial that addresses the most important aspects of scalability.
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