CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Performance Of A Customizable DMSO-Free Cryopreservation Media Formulation

  Cryopreservation enables cell therapy by storing cells long-term. A DMSO-free formula preserves cell viability and health, minimizing toxicities linked with traditional cryoprotectants.

• A Comparative Guide To CGTs: Modalities, Landscape, And Logistics

  Cell and gene therapies (CGTs) have the potential to revolutionize medicine. However, achieving therapeutic success requires advanced logistical consideration to ensure product safety and efficacy

• Intuitive Bioprocess Scale-Up From Bench Scale To Pilot Scale

  This study explores scaling a high-demand fed-batch process from bench to pilot scale, highlighting control parameter differences at 50L and 500L while maintaining consistent growth and product titers.

• Development Of LNP Formulations Using The KNAUER NanoScaler

  Lipid nanoparticles (LNPs) offer a robust solution for nucleic acids. The NanoScaler system optimizes this technology, enabling scalable and reproducible LNP formulations for diverse applications.

• A Bright Future For Eye Care: The Advanced Therapy Revolution Is Here

  Groundbreaking cell and gene therapies are revolutionizing eye care. Discover how advanced treatments target root causes, offering unprecedented hope for conditions previously deemed untreatable.

• Modern Lentiviral Platforms For Scalable Cell Therapy

  A new platform approach streamlines lentiviral vector design and manufacturing, boosting yield, lowering costs, and accelerating access to gene‑modified cell therapies worldwide.

• Mixing Of Various Dry Powdered Media And Buffers

  Explore how this mixing system efficiently handles various powdered media and buffers, ensuring precise solubilization and mixing in applications like cell culture and protein purification.

• Optimized Performance Model For Yield And Quality Of The mRNA Product

  Optimize your mRNA production by identifying an optimum set of conditions for the IVT reaction that produces high-quality mRNA in high yield using a design of experiment (DoE) approach.

• Extractables In Single-Use Systems Used In ADC Manufacturing

  To address concerns about using organic solvents in the ADC process, extractables studies were conducted on a disposable chromatography column housing and two different disposable flow paths.

• ATMP Cryopreservation Done Right - Best Practice In Small Volume Cryo-Freezing

  Explore best practices for cryopreserving small-volume advanced therapy medicinal products (ATMPs), emphasizing sterility, cell viability, and efficiency using innovative single-use systems and aseptic connectors.