CAR T-cell therapy is advancing in solid tumors by improving target selection, trafficking, tumor-microenvironment resistance, and long-term function, but major biological barriers still require combined solutions.
- Rethinking ATMP Assurance When Sterility Timelines, Reality Misalign
- Navigating GMP Biosafety Challenges In ATMP Manufacturing
- Ensuring Quality Of CGT Materials
- Zymeworks Shares Its Design Rationale (And Wins) In Early-Phase ADC Trials
- Ever Wonder What Running A $50B Capital Facilities Project Feels Like?
- Generative AI Can Write The Code, But Who Builds In The Quality?
- From "Live Drug" To Precision Tool: Redefining CAR T Safety
- UK's Decentralized Manufacturing Could Be A Revolution; Mind The Risk
CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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Factors Influencing CD34+ Cell Collection Efficiency In Leukapheresis
Efficiently collecting sufficient peripheral blood stem cells is paramount for successful transplantation, necessitating a deeper understanding of influencing factors and procedural nuances.
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Real-Time And In-Line Raman Spectroscopy For Glycan Quality Analysis
This study details the use of in-line Raman spectroscopy to monitor mAb glycan profiles within a production bioreactor, highlighting its potential for automation and customization.
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Enabling The Rapid, Reproducible Manufacturing Of TranspoCART Cells
Learn how an innovative technology streamlines Transpocart cell production, making rapid and consistent manufacturing a reality for cell therapies.
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Streamline AAV-Based Gene Therapies With Off-The-Shelf Plasmids
Standardized, well-characterized plasmids and streamlined platform processes can significantly accelerate viral vector development, improve consistency, and support scalable, high-quality gene therapy manufacturing.
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Digital Standardization: Accelerating Gene Therapy Tech Transfer With Confidence And Compliance
Fragmented, manual data practices slow tech transfer and increase risk; centralized digital CMC systems standardize workflows, improve transparency, and accelerate onboarding while maintaining compliance.
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Electroporation Enables Efficient Antibody Discovery By Mammalian Display
Therapeutic antibody developers leverage mammalian display to identify promising candidates. Electroporation enables superior sequence diversity, enhanced library coverage, and streamlined workflows.
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Ultra-Low Cross-Linked Microgel Purification
ULC microgel purification is often slowed by linear polymer contamination and limitations of centrifugation. Explore how hollow fiber TFF improves filtration efficiency and supports scalable processing.
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High-Throughput Lipid Separation For LNP Formulations
Lipid nanoparticles (LNPs) carry immense potential as delivery systems. Learn about the development of isocratic and gradient methods for high-throughput separation of lipids used in LNP formulations.
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How We Used Intelligent Automation to Transform Vendor Selection
Discover how your small biotech can achieve faster timelines, improved cost control, and more strategic, transparent choices with a platform leveraging intelligent automation.
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IVT mRNA Encapsulation Efficiency Assessment
In vitro transcribed mRNA revolutionizes biotherapeutics, which necessitates thorough quality assessments. See how an analyzer system enhances encapsulation efficiency and CQAs in IVT mRNA workflows.
NEWSLETTER ARCHIVE
- 04.03.26 -- Zymeworks Shares Its Design Rationale (And Wins) In Early-Phase ADC Trials
- 04.02.26 -- Navigating GMP Biosafety Challenges In ATMP Manufacturing
- 04.01.26 -- The In Vivo Cell Therapy Shift On Display At PMWC 2026
- 03.31.26 -- STREAM Edition: Take The Lead With A GS Cell Line Development Kit
- 03.31.26 -- UK's Decentralized Manufacturing Could Be A Revolution; Mind The Risk
CELL AND GENE CONTENT COLLECTIONS
While there are opportunities to scale, there are also manufacturing gaps, capacity issues, and production timelines that require improvement to do so. And then, of course, there’s cost. Because scale up and scale out are significant to everyone in the sector, we’ve curated insightful editorial that addresses the most important aspects of scalability.
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