CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Large Volume Tris And DPBS Buffer Preparation

  Explore a solution for efficiently mixing sinking powders that tend to accumulate on the bottom and in the corners of the bag.

• Understanding & Enhancing Natural History Studies’ Value In Rare Diseases

  Registry and natural history studies can be very important to the clinical development of therapeutics in rare diseases. To accommodate these advances in knowledge, study design flexibility is a must.

• Implementing High Cell Density Cryopreservation In Your Seed Train

  Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.

• A Simple Flow Cytometry-Based Assay For Detecting CAR Expression

  Learn more about fluorescent-labeled recombinant proteins that allow chimeric antigen receptors (CARs) to be directly stained and detected by flow cytometry.

• Scale From Cell Factory Systems To A Bioreactor Without Affecting CQAs

  The challenge was to identify an effective, replicable, and large-scale LVV manufacturing process to meet the growing manufacturing demand without affecting critical quality attributes.

• CHO Culture: Bioprocess Modes Batch Fed-Batch and Perfusion

  Explore the differences between three cell culture bioprocesses using bench-scale CHO cells, and why tracking specific parameters is important to achieving the inoculation of bioreactors at high viability.

• How Dwell Volume And Extra-Column Volume Impact Method Transfer

  Understand how system factors like dwell volume and extra-column volume contribute to method performance across labs and how this knowledge can increase the success of method transfer.

• Genome Editing of Human Primary T Cells With Lipid Nanoparticles

  We show CRISPR/Cas9-mediated knockouts of the T cell receptor and explore multi-step LNP engineering to produce TCRɑβ KO CAR T cells, a promising approach towards allogeneic CAR T cell therapy.

• Improve Productivity In CHO-K1, CHO-S, And DG44 Cells

  This commercially available platform can enhance process productivity and reduce development time, thereby enabling potential reductions in manufacturing costs and accelerating time-to-market.

• Evaluating A Flexible LC Platform

  Learn about a premier system offering a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the development and manufacturing of biotherapeutics.