Engineered oncolytic viruses are emerging as a promising way to target tumors, deliver immune-stimulating payloads, and improve treatment of metastatic cancer.
- Emerging Technologies In Aseptic Processing: Hype Vs. Operational Reality
- Use Of AI In FDA Inspection Activities: Strategies For Effective Preparation
- A Comparison Of 6 Analytical Validation Guidelines Using Data Envelopment Analysis
- Inside AstraZeneca's Fully Electrified Cell Therapy Facility
- AI Has Arrived In Biotech CMC Amid Patchwork Governance
- Driving Gene Therapy Beyond Rare Disease Will Define The Next Era Of CGT
- CDMO Selection: Start With The Relationship, Not The RFP
- Why FAT Should Confirm Alignment, Not Reveal Its Absence
CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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![GettyImages-2047658928 RNA Protein]( "In Vivo RNA Tuning For Liver Gene Editing Efficiency")
In Vivo RNA Tuning For Liver Gene Editing EfficiencyRNA sequence and guide modifications, delivery platform design, and dose optimization all contribute to improved gene editing outcomes, which offers a clearer path toward safer, more potent, and scalable mRNA-based therapeutics.
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![Drug Safety GettyImages-1265108955]( "Optimizing Safety Measures For rAAV Therapies")
Optimizing Safety Measures For rAAV TherapiesExplore common process-related impurities found in recombinant Adeno-Associated Virus (rAAV) vectors and the analytical testing methods used for these residuals.
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![GettyImages-1341292033-tablet-cleanroom-equipment-protective-gloves]( "Cleanroom Recovery. Proven Results. Contamination Control Case Studies")
Cleanroom Recovery. Proven Results. Contamination Control Case StudiesThrough this collection, review how a proven, automated solution can help facilities stay compliant, operational, and protected — whether in a crisis or during planned maintenance.
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![GettyImages-627023398 clinical lab]( "AAV Viral Titering Using Nanoplate-Based Digital PCR")
AAV Viral Titering Using Nanoplate-Based Digital PCRExamine how nanoplate-based digital PCR streamlines AAV titering, providing faster results and greater accuracy, advancing gene therapy development from the lab to the clinic.
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![GettyImages-1500981700 cell culture]( "Automated DNA Clean-Up Using Magnetic Bead-Based Methods")
Automated DNA Clean-Up Using Magnetic Bead-Based MethodsDiscover how to improve DNA clean‑up through a precise magnetic bead–based workflow, as well as how optimized liquid handling enhances yield, purity, and reproducibility for higher confidence in results.
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![GettyImages-1162413622-vials-organs-scientist-dna-strand]( "A Novel Patient-Derived Colorectal Cancer Organoid Platform")
A Novel Patient-Derived Colorectal Cancer Organoid PlatformPatient-derived organoids are revolutionizing drug discovery by mimicking tumors and predicting therapeutic efficacy. Discover a scalable bioprocess that enhances reproducibility and cost-effectiveness to pave the way for broader adoption.
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![Scientist Using Tablet In Lab GettyImages-1354172577]( "384-Well Microplate Time Resolved Fluorescence (TRF) Immunoassay")
384-Well Microplate Time Resolved Fluorescence (TRF) ImmunoassayExamine how innovative sandwich ELISAs in a 384-well format can be utilized with a sensitive reader for high-throughput screening to quantify Human IgG and IFN gamma.
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![GettyImages-2151689067 cell culture medium]( "The Proven, Practical Gateway To Upstream Process Intensification")
The Proven, Practical Gateway To Upstream Process IntensificationN-1 perfusion enables higher inoculum densities, faster production, and reduced costs without altering fed-batch processes. Explore a practical path to intensification for biologics manufacturers.
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![antibody molecules-GettyImages-2165626333]( "Evaluating Antibody Fragment Purification Using VH3 Resin")
Evaluating Antibody Fragment Purification Using VH3 ResinExplore how VH-domain targeting enables efficient purification of VH3 antibody fragments and bispecific formats, with strong recoveries and flexible wash conditions that support improved purity.
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![GettyImages-2163606903-gloves-pipet-cell-culture-assay]( "Rapid Selection Of High-Performance CHO Basal And Feed Media")
Rapid Selection Of High-Performance CHO Basal And Feed MediaA CHO-S bispecific antibody program needed a better basal and feed media combination. Learn how the screening of 180 conditions in 12 weeks identified one that delivered 38% higher titers.
NEWSLETTER ARCHIVE
- 06.12.26 -- Why Cell And Gene Therapy Has Not Reached More Patients — And Why Clinical Operations Is The Bridge
- 06.11.26 -- Translating Discovery Into Clinical Success
- 06.11.26 -- Bridging Innovation And Manufacturing In Cell & Gene Therapy
- 06.11.26 -- Why Contamination Control By Design Should Matter To Your CDMO
- 06.10.26 -- Control Contamination In Material Transfer Process
- Driving Gene Therapy Beyond Rare Disease Will Define The Next Era Of CGT
- CGT Manufacturing Shifts From Capacity To Strategy
- Dr. Peter Marks On Why Gene Therapy May Need A New Regulatory Playbook
- Regeneron Advances In Vivo Gene Therapy For Hearing Loss
- Sana, Mayo Clinic Advance A New Model For Cell Therapy Delivery In T1D
CELL AND GENE CONTENT COLLECTIONS
While there are opportunities to scale, there are also manufacturing gaps, capacity issues, and production timelines that require improvement to do so. And then, of course, there’s cost. Because scale up and scale out are significant to everyone in the sector, we’ve curated insightful editorial that addresses the most important aspects of scalability.
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