CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Review Of Applications And Processes In Fixed-Bed Bioreactors

  Gain insights and guidelines for developing new processes in this review evaluating publications on the applications of single-use, scalable fixed-bed bioreactors for adherent cell culture processes.

• Optimizing Human iPSC Aggregate And Organoid Production For Bioprinting

  This study aimed to identify the optimal cell culture conditions to yield high cell density and maintain high cell viability with consistent aggregate morphology and pluripotency marker expression.

• Targeted Indication Selection Using Adaptive Design

  What is a Simon 2-stage design, and how was it used to enable each tumor-specific cohort in a Phase 2, multi-cohort oncology trial to be independently assessed for objective response rates?

• A New Way To Perform mAb Capture

  Combining high-productivity chromatography methods and SU affinity membranes delivers a viable alternative to the current packed bed Protein A capture techniques for intensified purification of mAbs.

• Supporting A CAR T-Cell Therapy Study In Hematologic Malignancies

  To address a life-threatening complication of immunotherapy in hematologic malignancies, a U.S. biotech company developed a novel compound.

• Comparing Serum-free To Serum-Supplemented Media

  Reducing serum in vaccine manufacturing is a key consideration for lowering costs and improving supply security. We compare performance in serum-free versus serum-supplemented media.

• Zero To Final Fill: How HUGEL Implemented Its First Single-Use Lines

  As regulations tighten, biomanufacturers are adopting single-use tech to boost compliance, reduce labor, and streamline fill-finish operations from the ground up.

• Accelerate Process Development With Automated Aseptic Sampling

  Discover how implementing automated sampling systems enabled Takeda Pharmaceuticals to achieve new efficiencies in process development.

• Manufacturing Challenges With High Concentration Biologics

  Explore key process operations, some of the challenges in manufacturing high-concentration biologics, and factors to consider for process optimization.

• Comparing In-Line Vs At-Line Variable Pathlength Tech For UF/DF

  Discover how rapid amino acid profiling improves media insight, detects variability, and supports real-time optimization for stronger bioprocess control, as well as strategies to reduce risk.