CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Untouched Tumor Cell Isolation Improves NGS Analysis, Enrichment Of Cancer Stem Cells

  Here, bulk tumor and isolated tumor cells were subjected to whole exome sequencing (WES) to assess the impact of non-tumor cell depletion on the sensitivity of downstream NGS analyses.

• Improvements In Recovery, Reproducibility, And Matrix Effects With A Novel Solid Phase Extraction Sorbent

  In this study we review a successful next generation reversed  solid-phase extraction (SPE) product that produces cleaner extracts with simpler protocols and faster processing time.

• Optimizing Accuracy Performance On A Beckman Coulter Biomek

  Explore an approach for optimizing pipetting accuracy on a Beckman Coulter Biomek liquid handler using MVS® measurement information.

• Capitalize On Regulatory Expertise To Simplify FDA Complexities

  Get an overview of the global approval landscape, pathways to approval, including typical impediments to success, and the importance of formulating a robust clinical development program as made possible with the help of an experienced and well-resourced CRO.

• BEH C₁₈ Batch-To-Batch Robustness For The Analysis Of Rosuvastatin And Impurities

  The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C₁₈ Columns. Discover the findings of this study.

• Particulate Contamination Levels In Single-Use Systems

  We investigate material adsorption of mRNA-encapsulated lipid nanoparticle (LNP) formulation comparing the Aramus fluoropolymer bag to commonly used glass vials and polypropylene (PP) cryotubes.

• Method Migration Of Size-Exclusion And Ion- Exchange Methods For Monoclonal Antibody Analysis

  Discover how combining this system with modern UHPLC columns could make data more accurately interpreted through greater efficiency, selectivity, and enhanced resolution.

• Using Dual Dye Ratiometric Technology To Quantify The Impact Of Pipette Tip Type

  Testing volume transfer performance can give good indicators of tip performance and reliability. When tip reliability is in question, assay results, in turn, could be in question as well.

• Purification Of mRNA By Affinity Chromatography On CIMmultus® Oligo dT Column

  Increasing demand for messenger RNA (mRNA) as therapeutic product requires efficient and scalable purification methods. In this application note a CIMmultus® Oligo dT, a monolithic stationary phase is used for purification of mRNA from a capping mix of Luc2 RNA. The large channels and convective mass transfer within the stationary phase eliminate shear forces and allow high flow rates, which leads to very short purification times and high recoveries.

• Bacto CD Supreme FPM Consistently Supports Higher Growth And Plasmid Production In E. coli

  Traditional microbial media for E. coli often contain animal-origin components and are complex. Stemmed from an overall industry drive to develop animal origin–free (AOF) and chemically defined (CD) media, Gibco™ Bacto™ CD Supreme Fermentation Production Medium (FPM) supports process flexibility and consistency in production. Read the results of a head-to-head comparison between Bacto CD Supreme FPM and Terrific Broth (TB), a traditional microbial medium.