CELL & GENE ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• High-Throughput Lipid Separation For LNP Formulations

  Lipid nanoparticles (LNPs) carry immense potential as delivery systems. Learn about the development of isocratic and gradient methods for high-throughput separation of lipids used in LNP formulations.

• Formulation Development Of Enterically Protected Spray Dried Dispersions

  Adrulipase spray-dried dispersions were evaluated to create an orally delivered, enteric-protected enzyme. The lead formulation provided the best acid protection, rapid release, and stability.

• Navigating Commercial Logistics For CGTs: A Roadmap To Scalable, Patient-Centered Success

  The commercialization of cell and gene therapies requires a precise and resilient logistics model that can adapt to rapid demand and global expansion while maintaining a patient-first approach.

• Navigating Project Optimus And The Rapidly Changing Oncology Development Landscape

  Project Optimus and adaptive trial designs are reshaping oncology development, improving patient outcomes, and streamlining approval pathways.

• Scaling Of Impingement Jets Mixing For LNP Drug Production

  Delve into the intricacies of Impingement Jets Mixing (IJM) technology and its pivotal role in the scalable and reproducible production of Lipid Nanoparticles (LNPs) for drug delivery.

• A Scalable Manufacturing Platform For The Purification Of Stem Cell Derived Exosomes

  EV production scale increases require paired robust, scalable, and cost-effective downstream processes. Process parameters can be tailored for therapeutic exosome programs and allow for maximum exosome recovery.

• Correlating NGS Success With Sample Input Quality: A Large Scale Study

  DIN values offer a data‑backed way to identify which DNA samples are ready for successful sequencing. With strong correlations to sequencing performance, DIN thresholds help streamline workflows.

• Alternative Two-Step Mixed-Mode Approach To A mAb Purification Process

  Two post–Protein A capture two-step mAb processes were developed and compared to an archetypical three-step mAb purification process using two IEX steps after Protein A capture.

• Scale-Up Approaches For Culturing Adherent Cells

  For successful scale-up, see how optimizing process parameters such as attachment methods, gassing, and agitation can help reduce cell environmental stress, ultimately improving productivity.

• Enhancing Novel Developability Through Automated MS Analytics

  Growing biotherapeutic complexity demands MS workflows that can unify diverse datasets. Learn how automated approaches enhance data quality, streamline analysis, and support faster development.