Cell And Gene Articles, App Notes, Case Studies, & White Papers

1. A Closed Solution For T Cell Isolation And Activation 6/10/2022

   We outline the incorporation of magnetic bead separation technology into a cell processing platform designed specifically for cell therapy applications.

2. Efficient Transition Of Human Pluripotent Stem Cell Cultures From StemFlex™ Medium Into NutriStem® hPSC XF Medium On Matrigel® 8/13/2021

   Establishing ideal culture methods has been a known challenge in human pluripotent stem cell (hPSC) research since the late 90s. This paper reviews the suggested method for adapting hPSCs originally cultured in StemFlex™ to NutriStem® hPSC Medium. Read how for this transition, a simple and direct adaptation can be followed with cultures exhibiting similar morphology as well as higher levels of pluripotency when compared to StemFlex™.

3. Use Of Maurice CE-SDS In ICH Q6B-Based Biosimilar Comparability Exercises 11/23/2021

   The route to market for biosimilars places strong emphasis on the analytical and characterization techniques used to investigate the structure of the molecule and, importantly, side-by-side comparability. 

4. Formulation And Production Of A Blood‐Free And Chemically Defined Virus Production Media For VERO Cells 8/3/2021

   This paper reviews the success in using recombinant proteins to replace undefined plant hydrolysates to formulate a chemically defined medium that can efficiently support VERO cell expansion and virus production.

5. Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices? 4/29/2022

   We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.

6. Harnessing Critical Experience To Plan And Execute A Dual-Submission Study 3/8/2022

   Point-of-care (POC) tests offer significant convenience for patients and physicians, as well as cost savings for payers. Yet, achieving regulatory approval can be daunting. Discover how a clear strategy was developed to ensure that the necessary data to support both 510(k) clearance and CLIA waiver would be collected within a single clinical trial.

7. Tracking & Reporting Cellular Age Using Population Doubling Level & Not Cell Passage Number 1/4/2022

   Here we explain explain how passage number and population doubling level are related and provide guidance and tools to help labs adopt the best practice of tracking PDL of cell cultures to help bring standardization to their own experimental protocols as well as to the field.

8. Overcoming Method Transfer Challenges 6/24/2022

   Although development and quality control labs might be slow to replace existing technologies, modernization can benefit legacy methods and future development activities.

9. From Cell Culture To Target Protein: Exploring The Benefits Of The 24-Well Filter Plate Workflow 2/12/2021

   Over the last 5 years, the use of 24-well cell culture plates in laboratory applications has substantially increased. This market segment has expanded at an estimated 14% compound annual growth rate (CAGR)— a pace that is expected to continue in coming years. This paper explores the evaluation of the potential applications for its new AcroPrep 24-well filter plate line, plus the time savings it can achieve in protein purification workflows.

10. A 3D Cell Culture Primer: Freezing, Culturing, And Measuring Organoids 12/22/2021

    Organoid applications have virtually limitless potential, but they're much more complicated than 2D cultures or 3D spheroids. Here, we share a few tips, tricks, and best practices about freezing, culturing, and measuring organoids that can help you dive into 3D cell culturing right away.