Cell And Gene Articles, App Notes, Case Studies, & White Papers

1. 3D Cell Culture: From Academia To Big Pharma 12/22/2021

   While literature had long praised the promise of 3D, the industry uptake didn't accelerate until it became operationally feasible to produce 3D work at scale. Commercial tools and technologies that make 3D more accessible and less labor-intensive have helped make that happen.

2. Subvisible Particulate Matter Testing 8/31/2020

   This application note demonstrates the capabilty of advanced, automated systems for subvisible particle testing in injections, ophthalmic solutions, and lipid emulsions. 

3. Contract Testing Lab Quickly Responds To Increased Customer Requests For Nitrosamine Services 2/23/2022

   A mass spectrometer solution accompanied with a security software enabled Pharma & Tech to develop their nitrosamine impurity testing services in less than two months, as they responded to evolving global regulatory guidelines.

4. Markers And Methods To Verify Mesenchymal Stem Cell Identity, Potency, And Quality 2/10/2021

   This white paper defines and discusses the evolution of MSC nomenclature and provides a detailed description of MSC markers and how they may vary by tissue source and species. Learn how to standardize MSC characterization by selecting markers for isolation, characterization, and validation.

5. Vendor Partnering In Bioprocess Manufacturing, Supply Chains 8/16/2021

   New single-layer assemblies, made without the curing agents, antioxidants, plasticizers, or adhesives that represent potential contamination sources, may offer companies a safer, more efficient choice.

6. Vaccine Production Process Development: 4 Best Practices For Scaling Up 5/14/2021

   The vaccine production process is continually refreshed by new tools and technologies which imposes challenges on process development scientists: They're the ones who have to align and optimize new methods and means with legacy products and systems. By carefully crafting a customized modular process from end to end, process development scientists can glean the benefits of new technologies without starting from scratch with each new iteration. How can researchers working on vaccine production optimize their process with customization in mind?

7. Protein Expression Heterogeneity With Milo, The First Single-Cell Western System 2/18/2021

   Every cell is unique, making cell-to-cell heterogeneity important in many areas of biomedicine including cancer pathogenesis, immuno-oncology and regenerative medicine. More and more high-profile publications are using single-cell analysis techniques to reveal variability in cellular response to a drug or stimulus. Milo, the first and only Single-Cell Western platform out there, lets you do Western blotting at the single-cell level.

8. Using Avi-Tag Biotinylated Proteins To Determine Protein Interaction Kinetics And Affinity With Surface Plasmon Resonance 3/2/2021

   Surface plasmon resonance (SPR) is a powerful, accurate, and direct way to measure protein interactions in real-time without the need for antibodies or detection reagents. In this study, we employ R&D Systems Avi-tag Biotinylated Proteins along with streptavidin Series S chips to specifically and uniformly capture proteins in a Biacore experiment, as an alternative to chemical or amine coupling.

9. Phase 1 Trials: Strategies For Site Selection And Dose-Escalation 11/18/2021

   This white paper explores key considerations for site selection and dose-escalation design strategies in early-phase oncology trials.

10. Identify And Select Optimal CAR T Phenotypes 1/22/2021

    This application note demonstrates how the Berkeley Lights platform can be used to identify single T cells that maintain proliferative ability while secreting specific cytokine combinations and exhibiting desired tumor killing activity.