FEATURED CONTENT

• Background-Free Analysis Of Mouse TILs

  Syngeneic mouse tumor models are crucial for immunotherapy research, but variability in TILs and nonspecific binding complicate analysis. Discover how blocking reagents help but make the process more labor-intensive.

• Sensitive Monitoring Of CAR+ T Cells In Peripheral Blood

  Investigate how CAR-T cells treat hematopoietic malignancies as well as the correlation between flow cytometry and qPCR in monitoring CAR-T cell therapy, which validates their combined use for accurate assessment.

• Multicolor Immunophenotyping Of Human Tumor Cells

  Flow cytometric phenotyping is crucial for immunotherapy to enable precise immune monitoring. Discover how standardized assays with an 8-color cocktail enhance the understanding of tumor immunity and therapeutic impacts.

• Flow Cytometric Analysis: Differentiation Potential Of Human Stem Cells

  Explore an assay kit that simplifies handling with a methylcellulose-free medium and clear flow cytometric readout, which enhances automation and high-throughput sample acquisition for versatile research.

• Manufacturing IPC/QC Of Gene-Engineered HSCs

  In-process and quality control ensure consistent manufacturing of gene-engineered hematopoietic stem cells. Discover an engineering process that enhances production through viral transduction and integrated sampling pouches.

• Multiparameter Characterization Of CAR-T Cells

  Discover how innovative in vitro assays for CAR-T cells can enhance therapeutic outcomes by providing detailed insights into their properties and behaviors throughout pre-clinical and clinical development.

• Flow Cytometric Assays For CAR-T Cell Manufacturing And Patient Monitoring

  CAR-T cell therapy shows unprecedented efficacy in targeting cancer. Explore a device that simplifies the complex manufacturing process and enables automated CAR-T cell generation to ensure quality control and phenotyping.

• Determination Of Immune Cell Composition And CAR-T Cells

  Discover a system that automates CAR-T cell production using flow cytometry and analyzers for precise monitoring as well as learn about the sample preparation, instrument setup, and data analysis.

• Enhancing Cell And Gene Therapy: The LVV Platform Advantage

  Many drug development platforms focus solely on cost reduction or improved process efficiency, offering few, if any, solutions to bolster biological performance.

• Six Tips For Effective Assay Validation For CGT With A Focus On Flow Cytometry

  Gain insights and key recommendations from industry and regulatory experts on navigating assay validation for cell and gene therapy throughout the product development lifecycle.

• 8 Tips To Improve Compensation In Multicolor Flow Experiments

  Flow cytometry compensation is critical, for it directly impacts data accuracy and quality. Here, we share eight tips to improve compensation in multicolor flow experiments.

• 4 Ways Your Droplet Sorter May Harm Your Cells

  Learn the 4 physical conditions that occur during droplet sorting, which may keep your cells from being happy.

• Isolation Of Antigen Specific CD8+ T Cells Using A Microchip-Based Cell Sorter

  Here, we demonstrate the capacity of a specific bench top sorter to allow for completely aseptic sorting conditions by using the system to sort cancer antigen-specific cytotoxic T cells out of PBMCs.

• Isolation Of CD19 CAR T Cells Directly From Patient Samples

  Isolating fully functional CAR T cells requires high quality cell separation. See how we successfully and efficiently isolated CD19 CAR T cells with the MACSprep™ CD19 CAR MicroBead Kit, human.

• Flow Cytometry Analysis Of Chemokine Receptors Expressed On Human NK Cells

  Learn how the knowledge generated by a deep and thorough analysis of chemokine receptors on natural killer (NK) cells can be helpful to scientists studying certain cancers and diseases.

• Flow Cytometry Analysis Of Isolated NK Cells From Whole Blood

  Here, we describe the multicolor flow cytometry analysis necessary to study natural killer (NK) cell phenotype and the function of isolated NK cells from whole blood.

• Generation And Preclinical Applications Of Humanized Mouse Models

  Here, we show an automated experimental setup for human CD34+ HSC enrichment from umbilical cord blood for the successful generation of humanized mouse models.

• Effective Enrichment Of Human TILs

  Research is being done to study a new method for isolating TILs from human colon tumor xenografts that could be more efficient and effective than traditional methods.

• CD56 Cell Depletion From PBMCs Applied To Validate A HIV-Specific ADCC Mechanism

  Explore results from a study that utilized an in vivo model to assess the antibody-dependent cellular cytotoxicity (ADCC) activity of antibodies to clear HIV-infected cells.

• Antigen-Specific Restimulation Of CD8+ T Cells By Cross-Presenting DCs

  High-quality automated cell isolation and consistent cell culture and stimulation conditions are required for successful immuno-oncology studies. See how CD8+ T cells and XP-DCs were isolated using MACS® technology.