Insights on Discovery

  1. Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides 4/23/2025

    To overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.

  2. Advancing Cytokine, Immune Cell Characterization For Precision Bioanalysis 4/23/2025

    Unlock deeper insights into immune regulation and accelerate therapeutic discovery by adopting our next-generation inflammatory response assay.

  3. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

    Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.

  4. Optimizing qPCR For Broad-Range Transcript Detection In Anti-PD-1 Therapy 4/23/2025

    Optimize qPCR protocols for greater sensitivity and reproducibility to accurately measure immune-related gene expression and better identify patients who will benefit from anti-PD-1 immunotherapy.

  5. Quantifying, Mapping ATP Distribution Within Tissues To Inform Therapeutic Strategies 4/23/2025

    Leverage quantitative mass spectrometry imaging of ATP distribution to enhance tumor model selection and optimize targeted therapy development through precise mapping of metabolic activity.

  6. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

  7. Distribution Of Standard-Of-Care Antituberculosis Drugs In Cynomolgus Macaque Lungs 4/23/2025

    Incorporate individual variability into PBPK models and build on HRZE lung distribution data in NHPs to optimize anti-TB dosing strategies and advance PK/PD research in tuberculosis.

  8. Multimodal Stratification Of Predictive Biomarkers In Head And Neck Cancers 4/23/2025

    By identifying and utilizing predictive biomarkers, learn how researchers can enhance the effectiveness and safety of cytokine-based immunotherapy in head and neck cancers.

  9. Uncovering Novel Therapeutic Targets In Immune Checkpoint Inhibitor Resistance 4/23/2025

    Use spatial proteomics and AI-driven cell segmentation to reveal tumor-immune interactions and discover new targets to overcome resistance to immune checkpoint inhibitors in metastatic cancer.

  10. A Novel Patient-Derived Colorectal Cancer Organoid Platform 4/22/2025

    Patient-derived organoids are revolutionizing drug discovery by mimicking tumors and predicting therapeutic efficacy. Discover a scalable bioprocess that enhances reproducibility and cost-effectiveness to pave the way for broader adoption.