Insights on Discovery

  1. Thermal Stability Of Phosphoramidites In Oligonucleotide Synthesis 3/5/2025

    Crucial for efficacy, thermal stability in RNA/DNA therapies hinges on phosphoramidites: A study highlights key factors for process safety and quality in oligonucleotide development.

  2. CRISPR Off-Target Editing: Prediction, Analysis, And More 2/28/2025

    A crucial consideration for researchers is off-target editing – unintended DNA modifications at sites other than the intended target. Explore the complexities and strategies to mitigate these effects.

  3. Logical Scale Out Before Scale Up 2/24/2025

    Explore how synthetic biology and a "scale-out" biomanufacturing strategy can unlock "infinite diversity in infinite combinations," optimizing MSC functionality for superior outcomes.

  4. CD73: A Team Player Caught In The "AKT" Of Wound Healing And Cell Survival Via MSC Exosomes? 2/24/2025

    CD73, found in MSC exosomes, is a key player in tissue repair. Discover how this protein contributes to cell survival and the intricate process of wound healing.

  5. The Immortal Question: Can MSCs Be "Like A Cell Line But Not A Cell Line?" 2/21/2025

    Mesenchymal Stem Cells (MSCs) hold immense therapeutic promise. Can we harness their potential by making them more like consistent cell lines, without losing their unique advantages? Let's explore.

  6. EVs Answer To The CAR-Tease: Targeted Exosomes 2/21/2025

    Researchers are exploring extracellular vesicles to deliver CARs, potentially offering safer, more accessible, and effective treatments compared to current CAR-T cell therapies.

  7. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.

  8. Variant-Aware Therapeutic Guide Selection 2/21/2025

    Discover a technology that identifies CRISPR guide RNAs with minimal off-target effects for therapeutic gene editing by screening thousands of genomes and incorporating genetic diversity across populations.

  9. SAFER Detection™ For Efficient Interrogation Of DNA Rearrangements 2/21/2025

    Learn about SAFER Detection™, a Next-Generation Sequencing (NGS) based method for the efficient identification of DNA rearrangements in gene-edited human cells.

  10. A Standardized T Cell Backbone Panel For Immune Monitoring Of Adoptively Transferred Cellular Therapies 2/14/2025

    This validated 22-marker flow cytometry panel enables deep immune profiling to identify key biomarkers influencing ACT efficacy — optimizing cell therapy outcomes and improving patient responses.