Insights on Discovery

31. Optimizing qPCR For Broad-Range Transcript Detection In Anti-PD-1 Therapy 4/23/2025

    Optimize qPCR protocols for greater sensitivity and reproducibility to accurately measure immune-related gene expression and better identify patients who will benefit from anti-PD-1 immunotherapy.

32. Quantifying, Mapping ATP Distribution Within Tissues To Inform Therapeutic Strategies 4/23/2025

    Leverage quantitative mass spectrometry imaging of ATP distribution to enhance tumor model selection and optimize targeted therapy development through precise mapping of metabolic activity.

33. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

34. Distribution Of Standard-Of-Care Antituberculosis Drugs In Cynomolgus Macaque Lungs 4/23/2025

    Incorporate individual variability into PBPK models and build on HRZE lung distribution data in NHPs to optimize anti-TB dosing strategies and advance PK/PD research in tuberculosis.

35. Multimodal Stratification Of Predictive Biomarkers In Head And Neck Cancers 4/23/2025

    By identifying and utilizing predictive biomarkers, learn how researchers can enhance the effectiveness and safety of cytokine-based immunotherapy in head and neck cancers.

36. Uncovering Novel Therapeutic Targets In Immune Checkpoint Inhibitor Resistance 4/23/2025

    Use spatial proteomics and AI-driven cell segmentation to reveal tumor-immune interactions and discover new targets to overcome resistance to immune checkpoint inhibitors in metastatic cancer.

37. A Novel Patient-Derived Colorectal Cancer Organoid Platform 4/22/2025

    Patient-derived organoids are revolutionizing drug discovery by mimicking tumors and predicting therapeutic efficacy. Discover a scalable bioprocess that enhances reproducibility and cost-effectiveness to pave the way for broader adoption.

38. Time: A Crucial Factor In Therapeutics Development 4/21/2025

    Accelerate your mRNA development and strengthen your response to emerging health threats with next-generation, cell-free DNA template solutions designed for speed, quality, and reliability.

39. AAV Vectors In Gene Therapy Clinical Trials 4/16/2025

    AAV-based gene therapies show promise but face immune challenges. ELISpot assays help evaluate T cell responses, enhancing clinical trial design and improving therapeutic success.

40. Extractables And Leachables Assessment For Single-Use Systems 4/14/2025

    Efforts to enhance biopharmaceutical manufacturing focus on boosting production capacity sustainably and economically. Explore how optimizing processes with single-use solutions and monitoring leachables ensures product quality.