Insights on Discovery
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Peripheral Blood Mononuclear Cell (PBMC) Isolation Using Cell Fractionation Filters
5/28/2025
Discover how this Peripheral Blood Mononuclear Cell (PBMC) isolation method can transform CAR-T manufacturing by reducing costs, accelerating timelines, and improving patient accessibility.
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Signature Of Base Editor RNA Edits And Reduced Exogenous RNA Editing
5/28/2025
Learn how this groundbreaking method for distinguishing base editor-induced RNA edits can enhance the safety and efficacy of genomic medicines.
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Electroporation, LNPs For Targeted CRISPR/Cas9 Gene Editing In T-Cells
5/28/2025
This study compared non-viral transfection methods in primary human T-cells, demonstrating the feasibility of an LNP-based process encapsulating CRISPR/Cas9 and HDR template DNA in a single payload.
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CRISPR-Associated RNA-Guided Nucleases For Precise Gene Editing
5/28/2025
Explore how advanced CRISPR technologies and proprietary delivery systems are transforming genomic medicine by enabling precise gene editing for a wide range of therapeutic applications.
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CRISPR System Enables CNS Biodistribution, mHTT Protein Reduction
5/28/2025
Discover how a diverse collection of RNA-guided nucleases, base editors, and reverse transcriptase editors with unique PAM recognition sequences can enable flexible and precise genome editing.
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AAV Vector Used To Deliver Gene Editing Tools To The Brain
5/28/2025
Discover how LETI-101's promising preclinical results and advanced manufacturing strategies are advancing gene editing therapy for Huntington's Disease.
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Potency Development For Cell & Gene Therapy Products
5/28/2025
This document outlines the development of potency assays for cell and gene therapy (CGT) products, with a focus on investigational therapies for Huntington's disease (HD).
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Allele-Selective Editing Of mHTT Results In Protein Reduction
5/28/2025
Review the data presented in this slideshow to understand how LETI-101’s precise gene editing technology and promising preclinical data are being used to advance Huntington’s Disease treatment.
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Enabling Transfer Of Raman Calibration Models Across Bioreactor Scales
5/16/2025
Raman spectroscopy has revolutionized manufacturing through real-time monitoring. Explore a system that enables a seamless calibration model transfer from small- to large-scale bioreactors to enhance scalability and efficiency.
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Replacement Of Traditional Adventitious Virus Testing
5/13/2025
Explore how molecular-based technologies, including PCR and Next Generation Sequencing, are transforming viral safety testing by offering broader, more effective alternatives to traditional animal-based methods like in vivo assays.