Insights on Discovery

  1. 3D Cell Culture Reveals Undetectable Drug Efficacy In Traditional Systems 3/10/2025

    Drug discovery now targets cancer stem cells (CSCs) to achieve long-term tumor eradication, which moves beyond traditional chemotherapeutics. Discover an advanced screening platform that better predicts CSC inhibitor efficacy.

  2. Navigating Next-Generation Quality Control Strategies For AAV Testing 3/10/2025

    AAV-based gene therapies, while promising, require rigorous quality control through advanced methodologies to ensure safety, efficacy, and regulatory compliance.

  3. Hepatitis B - Global Clinical Trial Landscape 3/6/2025

    As Hepatitis B virus (HBV) clinical trials advance, refining therapeutic endpoints and integrating novel treatment strategies are essential to transforming Hepatitis B management.

  4. Thermal Stability Of Phosphoramidites In Oligonucleotide Synthesis 3/5/2025

    Crucial for efficacy, thermal stability in RNA/DNA therapies hinges on phosphoramidites: A study highlights key factors for process safety and quality in oligonucleotide development.

  5. CRISPR Off-Target Editing: Prediction, Analysis, And More 2/28/2025

    A crucial consideration for researchers is off-target editing – unintended DNA modifications at sites other than the intended target. Explore the complexities and strategies to mitigate these effects.

  6. Logical Scale Out Before Scale Up 2/24/2025

    Explore how synthetic biology and a "scale-out" biomanufacturing strategy can unlock "infinite diversity in infinite combinations," optimizing MSC functionality for superior outcomes.

  7. CD73: A Team Player Caught In The "AKT" Of Wound Healing And Cell Survival Via MSC Exosomes? 2/24/2025

    CD73, found in MSC exosomes, is a key player in tissue repair. Discover how this protein contributes to cell survival and the intricate process of wound healing.

  8. The Immortal Question: Can MSCs Be "Like A Cell Line But Not A Cell Line?" 2/21/2025

    Mesenchymal Stem Cells (MSCs) hold immense therapeutic promise. Can we harness their potential by making them more like consistent cell lines, without losing their unique advantages? Let's explore.

  9. EVs Answer To The CAR-Tease: Targeted Exosomes 2/21/2025

    Researchers are exploring extracellular vesicles to deliver CARs, potentially offering safer, more accessible, and effective treatments compared to current CAR-T cell therapies.

  10. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.