Insights on Discovery

  1. CRISPR-Associated RNA-Guided Nucleases For Precise Gene Editing 5/28/2025

    Explore how advanced CRISPR technologies and proprietary delivery systems are transforming genomic medicine by enabling precise gene editing for a wide range of therapeutic applications.

  2. CRISPR System Enables CNS Biodistribution, mHTT Protein Reduction 5/28/2025

    Discover how a diverse collection of RNA-guided nucleases, base editors, and reverse transcriptase editors with unique PAM recognition sequences can enable flexible and precise genome editing.

  3. AAV Vector Used To Deliver Gene Editing Tools To The Brain 5/28/2025

    Discover how LETI-101's promising preclinical results and advanced manufacturing strategies are advancing gene editing therapy for Huntington's Disease.

  4. Potency Development For Cell & Gene Therapy Products 5/28/2025

    This document outlines the development of potency assays for cell and gene therapy (CGT) products, with a focus on investigational therapies for Huntington's disease (HD).

  5. Allele-Selective Editing Of mHTT Results In Protein Reduction 5/28/2025

    Review the data presented in this slideshow to understand how LETI-101’s precise gene editing technology and promising preclinical data are being used to advance Huntington’s Disease treatment.

  6. Enabling Transfer Of Raman Calibration Models Across Bioreactor Scales 5/16/2025

    Raman spectroscopy has revolutionized manufacturing through real-time monitoring. Explore a system that enables a seamless calibration model transfer from small- to large-scale bioreactors to enhance scalability and efficiency.

  7. Replacement Of Traditional Adventitious Virus Testing 5/13/2025

    Explore how molecular-based technologies, including PCR and Next Generation Sequencing, are transforming viral safety testing by offering broader, more effective alternatives to traditional animal-based methods like in vivo assays.

  8. Direct Quantification Of Residual Host Cell DNA 5/13/2025

    Residual host cell DNA monitoring is vital in biologics manufacturing. Learn how digital PCR offers unmatched sensitivity and precision to ensure compliance with strict safety standards set by global regulatory agencies.

  9. A Duplex Assay For Quantification And Qualification Of AAV 5/13/2025

    Adeno-associated virus is a key gene therapy vector. Explore how digital PCR offers precise, standard-free quantification with improved consistency and inhibitor tolerance over traditional qPCR methods.

  10. Quantification And Qualification Of Adeno-Associated Virus 5/13/2025

    Explore how digital PCR technologies offer precise, reproducible AAV quantification to address qPCR limitations with streamlined workflows and dedicated CGT assays to support safe, consistent gene therapy development.