Insights on Discovery
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Minimize Off-Target Effects With Precision Genome Editing
3/20/2025
On the path to successfully delivering a safe and efficacious gene editing therapy to patients, drug sponsors must leverage a robust arsenal of tools to mitigate off-target effects on the genome. Said tools include in silico prediction software, especially those that consider epigenetic features when predicting off-target effects.
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Navigating The Evolving Landscape Of Immunotherapy in Oncology
3/17/2025
Immunotherapy is revolutionizing oncology, enhancing patient outcomes through targeted treatments. This evolving landscape includes checkpoint inhibitors, and personalized medicine, shaping the future of cancer care.
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Assessment Of Compound Toxicity Effects With High-Content Imaging
3/17/2025
3D cellular models and bioprinting enhance drug safety predictions and offer precise spatial control. Explore an automated method for generating liver models to improve reproducibility and reliability in toxicity testing.
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Automation Of 3D Intestinal Organoids Culture
3/17/2025
Gain insight into how 3D organoids promise better disease modeling and drug screening and how challenges like assay complexity, reproducibility, and scalability hinder their widespread adoption in drug discovery.
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Automating High-Throughput Screens Using Patient-Derived Organoids
3/17/2025
Many oncology drugs fail in later development stages due to inadequate predictive models. Explore how 3D cell models, like patient-derived organoids, offer a promising solution in the drug development process.
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The Future Promise Of Advanced Therapies In Ophthalmology
3/17/2025
Six years after the first approved gene therapy in ophthalmology, the field is experiencing a surge of activity. Delve into the exciting potential of advanced therapies for eye diseases.
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Automated Testing For Compound Toxicity Effects
3/17/2025
Explore how anti-cancer drugs' toxic effects on intestinal cells limit dosages as well as how 3D organoids and assay automation can enhance drug development by improving testing processes.
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Assessing Viability And Real-Time Apoptosis/Necrosis
3/17/2025
Malignant gliomas are aggressive brain tumors that resist standard treatments. Discover why researchers focus on real-time cell death dynamics to develop targeted therapies and promising strategies.
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Rapid Automated Selection Of Mammalian Cell Colonies
3/17/2025
Discover how a new technology cultivates mammalian cells into clonal colonies and images them using fluorescent assays to isolate clonal cell populations based on surface protein expression.
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AI-Enabled Phenotypic Analysis Of Label-Free Intestinal Organoids
3/10/2025
Discover how advanced 3D models and AI-enabled imaging techniques revolutionize organoid research, which provides accurate phenotypic analysis to monitor growth and development in various organoid types.