Insights on Discovery

  1. Understanding RNA Higher-Order Structure Dynamics For CRISPR Applications 5/5/2025

    Scientists are gaining valuable knowledge about the structural dynamics of guide RNAs used in CRISPR-Cas9. This deeper understanding could pave the way for improved gene editing tools.

  2. 8 Best Practices For Immunogenicity Assay And Companion Diagnostic Development In AAV Gene Therapy 5/2/2025

    Read more to understand why the partnership between gene therapy companies and diagnostic developers is crucial for advancing the field of gene therapy.

  3. How Translational Central Lab Services Facilitate Creative Solutions For Biomarker-Driven Studies 5/2/2025

    Explore the rise of biomarker-driven clinical trials, their benefits, and the complexities involved in their execution to learn about the importance of planning and overcoming challenges in translational studies.

  4. High-Sensitivity Residual E. coli DNA Testing Supporting Biologics, CGT Development 4/23/2025

    Advancements in high-sensitivity residual DNA testing enhance the precision of plasmid DNA purity analysis, ensuring compliance with regulatory standards critical for manufacturing processes.

  5. Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides 4/23/2025

    To overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.

  6. Advancing Cytokine, Immune Cell Characterization For Precision Bioanalysis 4/23/2025

    Unlock deeper insights into immune regulation and accelerate therapeutic discovery by adopting our next-generation inflammatory response assay.

  7. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

    Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.

  8. Optimizing qPCR For Broad-Range Transcript Detection In Anti-PD-1 Therapy 4/23/2025

    Optimize qPCR protocols for greater sensitivity and reproducibility to accurately measure immune-related gene expression and better identify patients who will benefit from anti-PD-1 immunotherapy.

  9. Quantifying, Mapping ATP Distribution Within Tissues To Inform Therapeutic Strategies 4/23/2025

    Leverage quantitative mass spectrometry imaging of ATP distribution to enhance tumor model selection and optimize targeted therapy development through precise mapping of metabolic activity.

  10. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.