Insights on Discovery

  1. Automating High-Throughput Screens Using Patient-Derived Organoids 3/17/2025

    Many oncology drugs fail in later development stages due to inadequate predictive models. Explore how 3D cell models, like patient-derived organoids, offer a promising solution in the drug development process.

  2. The Future Promise Of Advanced Therapies In Ophthalmology 3/17/2025

    Six years after the first approved gene therapy in ophthalmology, the field is experiencing a surge of activity. Delve into the exciting potential of advanced therapies for eye diseases.

  3. Automated Testing For Compound Toxicity Effects 3/17/2025

    Explore how anti-cancer drugs' toxic effects on intestinal cells limit dosages as well as how 3D organoids and assay automation can enhance drug development by improving testing processes.

  4. Assessing Viability And Real-Time Apoptosis/Necrosis 3/17/2025

    Malignant gliomas are aggressive brain tumors that resist standard treatments. Discover why researchers focus on real-time cell death dynamics to develop targeted therapies and promising strategies.

  5. Rapid Automated Selection Of Mammalian Cell Colonies 3/17/2025

    Discover how a new technology cultivates mammalian cells into clonal colonies and images them using fluorescent assays to isolate clonal cell populations based on surface protein expression.

  6. AI-Enabled Phenotypic Analysis Of Label-Free Intestinal Organoids 3/10/2025

    Discover how advanced 3D models and AI-enabled imaging techniques revolutionize organoid research, which provides accurate phenotypic analysis to monitor growth and development in various organoid types.

  7. 3D Cell Culture Reveals Undetectable Drug Efficacy In Traditional Systems 3/10/2025

    Drug discovery now targets cancer stem cells (CSCs) to achieve long-term tumor eradication, which moves beyond traditional chemotherapeutics. Discover an advanced screening platform that better predicts CSC inhibitor efficacy.

  8. Navigating Next-Generation Quality Control Strategies For AAV Testing 3/10/2025

    AAV-based gene therapies, while promising, require rigorous quality control through advanced methodologies to ensure safety, efficacy, and regulatory compliance.

  9. Hepatitis B - Global Clinical Trial Landscape 3/6/2025

    As Hepatitis B virus (HBV) clinical trials advance, refining therapeutic endpoints and integrating novel treatment strategies are essential to transforming Hepatitis B management.

  10. Thermal Stability Of Phosphoramidites In Oligonucleotide Synthesis 3/5/2025

    Crucial for efficacy, thermal stability in RNA/DNA therapies hinges on phosphoramidites: A study highlights key factors for process safety and quality in oligonucleotide development.