Insights on Discovery
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Proximal Tubule Kidney-Chip For Modeling Human Physiology
3/14/2024
Discover how an Organ-Chip can be used to create a comprehensive recapitulation of the proximal tubule, addressing the need for more human-relevant preclinical models in the pharmaceutical industry.
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Duodenum Intestine-Chip For Modeling Human Physiology
3/14/2024
Discover an Intestine-Chip that integrates the robust cell sourcing of organoids with Organs-on-Chips technology to overcome experimental limitations and yield a closer-to-human transcriptomic profile.
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Development And Characterization Of The Species-Specific Liver-Chip
3/14/2024
There is a growing need for more human-relevant preclinical models. Explore how Organ-Chips offer a viable solution and can be used to create a comprehensive recapitulation of the liver sinusoid.
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Characterization Of The Colon Intestine-Chip
3/14/2024
Learn about the development and characterization of Organ-Chips and what makes them the most comprehensive model of the colonic epithelial-endothelial interface that is commercially available.
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Testing The Transduction Of AAV-Based Therapeutics
3/14/2024
Organ-on-a-Chip technology has emerged as a solution to the limitations of conventional preclinical models. Learn how Liver-Chips can be used to test the delivery efficiency and safety of AAV vectors.
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Modeling Inflammation-Specific Immune Cell Recruitment
3/13/2024
Traditional models for studying inflammatory bowel disease (IBD) often fall short. See how the Colon Intestine-Chip was used to model the progression of IBD driven by immune cells more completely.
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Advanced In Vitro Duodenal Model For Toxicity Assessment
3/13/2024
Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
3/13/2024
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity
3/13/2024
An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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The Importance Of Specificity In Preclinical Drug Development Models
3/13/2024
It is crucial for models to not only detect toxic drugs but also to avoid erroneously identifying safe drugs as harmful. Learn about the importance of specificity in the early stages of drug development.