Cell And Gene Articles, App Notes, Case Studies, & White Papers

  1. Large Scale Purification Of Oligonucleotides With IEX 12/6/2024

    As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

  2. Bringing A Biosimilar For Oncology To Market: Injectable Packaging From Early Development To Commercialization 2/20/2024

    While in their early-stage development of a mAb biosimilar for oncology treatment, a large biopharmaceuticals company sought a packaging recommendation: a stopper to maintain high-quality standards.

  3. Extractables In Single-Use Systems Used In ADC Manufacturing 9/23/2024

    To address concerns about using organic solvents in the ADC process, extractables studies were conducted on a disposable chromatography column housing and two different disposable flow paths.

  4. Perfusion Cell Line Development For Intensified Processes 5/5/2025

    The biopharmaceutical industry is transforming by shifting to continuous and intensified upstream bioprocesses, which are driven by evolving demands. Discover the key goals and innovations shaping this transition for modern healthcare.

  5. Optimization And Scale-Up Of A Plasmid DNA Production Process 9/30/2025

    Optimizing pDNA production in E. coli requires strategic media selection and scale-up planning. Explore a study that identifies ideal conditions for high-yield manufacturing.

  6. Selecting A Platform Filter For High Concentration mAbs 4/9/2025

    Read more about how Fujifilm Diosynth Biotechnologies evaluated a prime filter with challenging simulant solutions and how the experimental data confirmed superior performance, which demonstrated twice the throughput.

  7. Streamline Your mAb Manufacturing With Strategic Development And CDMO Compatibility 6/4/2025

    Though the journey to mAb development begins at lab scale, for clinical trials and commercial distribution, a production process must be streamlined and scalable to 2,000 L production and above.

  8. Gene Therapy In Neurology: The Case For Optimism 1/14/2025

    Advancements in genetic therapy are revolutionizing the treatment of neurological diseases, with promising results from preclinical studies leading to clinical trials focused on safety and efficacy.

  9. Harnessing The Versatility Of Magnetic Beads In CAR T Cell Manufacturing 5/7/2025

    Explore advanced magnetic bead-based methods for isolating T cells, enabling high efficiency, scalability, and viability in CAR T cell manufacturing while addressing challenges posed by diverse patient samples.

  10. Testing Cell-Based Immunotherapeutics For Microbial Contaminants 10/23/2023

    In this study, two different immune cell preparations were evaluated for their compatibility with the Milliflex® Rapid System to establish a USP and EP compliant method for rapid sterility testing.