Harnessing The Versatility And Flexibility Of Magnetic Beads In CAR T Cell Manufacturing

Effective T cell isolation is crucial in the manufacturing of CAR T cell therapies, a promising approach for treating various diseases. Magnetic bead-based cell separation has become a preferred technique due to its simplicity, speed, and ability to isolate T cells with high purity and yield. Compared to traditional methods, this technology is gentler on cells, helping to maintain their viability and functionality—a critical factor for successful cell therapy products.

While magnetic bead-based methods offer efficiency, manufacturers often face challenges in isolating T cells from diverse patient source material. Variations in patient samples can impact T cell isolation efficiency, potentially affecting the final product.

This application note highlights the versatility of Gibco™ CTS™ Dynabeads magnetic beads in addressing these challenges. CTS Dynabeads are designed for clinical-grade settings and have demonstrated high efficiency in isolating T cells for CAR T cell manufacturing. We explore five unique T cell isolation methods using Gibco CTS™ Detachable Dynabeads, demonstrating the flexibility and advantages of each approach.