FEATURED ARTICLES

• Rapid Selection Of High-Performance CHO Basal And Feed Media

  A CHO-S bispecific antibody program needed a better basal and feed media combination. Learn how the screening of 180 conditions in 12 weeks identified one that delivered 38% higher titers.

• Achieving High Cell Purity With The CTS DynaCellect Magnetic Separation System

  Learn how closed-system automation, combined with expert technical guidance and protocol optimization, turned a persistent manufacturing bottleneck into a reliable, scalable process.

• Anticoagulant Selection Influences T Cell Purity And Yield In Whole Blood Isolation

  Lithium heparin reduces T cell purity to below 50% and spikes CD15+ contamination in whole blood workflows. See which anticoagulants consistently deliver above 90% CD3+ purity.

• Criteria For Effective Bioprocess Scale-Up

  Discover four essential bioprocess scale-up criteria and how each balances hydrodynamics, shear, and mass transfer across manufacturing scales.

• Demonstrating Bioprocess Scalability Through Platform Consistency

  Explore how a unified bioreactor design enables consistent process performance from bench to production, minimizing scale-up risk while maintaining cell growth and yield.

• Activate Advanced Contamination Control Technology To Safeguard Your Cell Therapy

  The most common contamination risks in cell therapy manufacturing are open processes that leverage different products, inflexible instruments, labor intensive workflows, lack of in-line monitoring, and zero failure tolerance.

• Integrated Upstream And Downstream Strategies For Robust Manufacturing

  Process robust mAb production requires understanding scale dependent cell environments, leveraging predictive models, and pursuing data driven control to minimize variability and optimize quality.

• Rethinking Peptones As First-Line Optimization Tools

  Peptones enhance CHO cell growth, viability, and yield, offering a fast, low-risk way to improve bioprocess performance without major process changes.

• How Can You Avoid Bioprocessing Risks When Using Cable Ties?

  Cable ties in bioprocessing can cause leaks, damage, and delays. See how switching to a uniform-sealing connector can significantly improve efficiency, reduce prep time, and minimize contamination risks.

• Simplify Process Scale-Up With An Innovative Single-Use Bioreactor

  Consistent cell growth and protein yields from 5 L to 5,000 L show how a unified bioreactor design can simplify scale-up, reduce risk, and accelerate upstream process development in bioproduction.

• Advanced Aseptic Filling Assembly Helium Integrity Testing

  Helium leak testing offers unmatched sensitivity for detecting micro-leaks in single-use fill-finish systems. Learn how tighter leak thresholds can strengthen aseptic processing and regulatory confidence.

• Product Recovery Study For Fill Finish Applications

  Surge bags are essential to fill finish efficiency, but poor drainage can cause costly product loss. Learn how drainage testing helps identify high-performance bags that maximize recovery and reduce waste.

• Molecular Approaches To Streamline Cell Therapy Product Analytical Testing

  Learn how rapid molecular methods of cell therapy testing like qPCR for mycoplasma, sterility, and lentiviral quantification are key to accelerating product release and timely treatment delivery.

• Advances In Analytical Method Selection And Technology Transfer

  Successful analytical method transfer is crucial for product quality and regulatory compliance. Learn best practices for tech transfer, including how gap assessments mitigate common risks and streamline bioprocessing.

• Streamlining Data For Efficient Therapeutic Manufacturing

  An integrated solution for impurity and sterility analysis streamlines data, supports regulatory compliance, and uses built-in algorithms to deliver accurate, actionable results quickly.

• Select The Best Analyte: A Guide To Effective Mycoplasma Testing

  As you build a Mycoplasma testing strategy to ensure drug safety, there are three analyte types to choose from: live Mycoplasma, RNA, and genomic DNA, each offering distinct advantages.

• A Paradigm Shift From Glass Benchtop Bioreactors

  Learn how a bench-scale single-use bioreactor offers process development advantages over traditional glass systems, including higher efficiency, increased productivity, and enhanced sustainability.

• Scalability From 5L To 50L Using The DynaDrive Single-Use Bioreactor

  Maintaining a consistent bioprocess when scaling from 5 L to 50 L is achievable. This study shows how to successfully scale processes while maintaining cell density, viability, and protein production.

• Consistent Improvement In CHO-K1 GS Performance With Efficient-Pro Feed 3 And Efficient-Pro Feed Enhancer

  Optimize your CHO-K1 GS cell line with advanced chemically defined, animal origin-free feeds. Achieve higher titers and reliable product quality.

• The Value Of Peptones For Cost-Effective Vaccine Manufacturing

  Peptones offer a strategic solution to key biomanufacturing challenges by enhancing cell culture performance, improving yields, and reducing production costs.

• Improved T Cell Expansion Using Closed, Automated Stirred-Tank Bioreactors

  A shift from traditional rocking motion systems to stirred-tank bioreactors can enhance T cell expansion, offering greater scalability and more intimate process control.

• Comparing Serum-free To Serum-Supplemented Media

  Reducing serum in vaccine manufacturing is a key consideration for lowering costs and improving supply security. We compare performance in serum-free versus serum-supplemented media.

• A Temperature-Stable Replacement For Animal Trypsin In Cell Dissociation Applications

  Improve cell dissociation with a gentle, recombinant enzyme. This temperature-stable protease shows dissociation kinetics similar to porcine trypsin but with lower cell toxicity and greater overall purity.

• Streamline Your mAb Manufacturing With Strategic Development And CDMO Compatibility

  Though the journey to mAb development begins at lab scale, for clinical trials and commercial distribution, a production process must be streamlined and scalable to 2,000 L production and above.

• The Role Of Peptones In Boosting Monoclonal Antibody Production

  Peptones have become a key tool in CHO cell bioprocessing, enhancing monoclonal antibody yield and quality.

• Optimize Your Approach To mAb Development

  To meet the growing demand for mAbs and their variants, it is important to leverage opportunities for optimization as well as work with suppliers that have the resources to help your workflow thrive.

• Finding An Optimal Harvest Solution By Considering Both Cost And Sustainability

  Optimize your bioprocessing harvest with single-use centrifugation. Reduce costs, waste, and space needs compared to traditional depth filtration methods.

• Single-Use Technology And Environmental Responsibility In Biopharmaceuticals

  Learn about strategies such as regional manufacturing and advanced single-use systems and their potential to minimize carbon footprint and enhance sustainable biomanufacturing.

• Scale-Up Approaches For Culturing Adherent Cells

  For successful scale-up, see how optimizing process parameters such as attachment methods, gassing, and agitation can help reduce cell environmental stress, ultimately improving productivity.

• Comparison Of Single-Use And Steel Fermentors For Malaria Vaccine Production

  Support the advancement of malaria vaccine development by leveraging innovative bioprocessing solutions to enable efficient, scalable, and accessible vaccine production worldwide.

• Intuitive Bioprocess Scale-Up From Bench Scale To Pilot Scale

  This study explores scaling a high-demand fed-batch process from bench to pilot scale, highlighting control parameter differences at 50L and 500L while maintaining consistent growth and product titers.

• Advances In Flow-Through Technology To Enhance mAb Polishing

  Optimize your monoclonal antibody purification with cutting-edge flow-through chromatography. Learn how POROS resins enhance polishing efficiency, improve aggregate removal, and streamline bioprocessing.

• The Importance Of Quality In Raw Material Selection

  Learn how to select high-quality raw materials for cell-based manufacturing in this exploration of the criticality of raw materials, from preclinical development to commercialization. 

• Enhanced mAb Production With High-Intensity Perfusion CHO Medium

  Reach new heights in mAb production with a high-intensity perfusion CHO medium designed to support consistently high product yield and quality in continuous perfusion cultures using CHO-K1 cells.

• The Value Of Peptones For Enhancing Biopharmaceutical Productivity

  Peptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.

• Difco TC Yeastolate Ultra-Filtered (TCY UF) In Scale-Up Optimization

  Explore how Difco™ TC Yeastolate ultra-filtered (TCY UF) enabled over 100% improvement in titer for CHO cell culture through feed optimization and bioreactor scalability in a real-world application.

• Production And Clarification Of Lentiviral Vectors

  Explore scalable processes for lentiviral vector production and clarification at the 50 L scale, utilizing the CTS LV-MAX system and single-use bioreactors for robust gene therapy manufacturing.

• Ensuring Product Safety And Purity With Mycoplasma And Sterility Testing

  Discover how the Applied Biosystems™ MycoSEQ™ Plus system and Applied Biosystems™ SteriSEQ™ Rapid Sterility Testing System can help accelerate your cell therapy manufacturing process.

• Achieving Titer Increase Up To 4-Fold While Maintaining Product Quality

  Discover customizable solutions for antibody manufacturing, as well as services for media optimization, feeding strategy optimization, and format conversion.

• Development To Large-Scale cGMP Production

  For manufacturers working with a dry powder medium (DPM), early consultation with a supplier can increase the likelihood of success. Uncover a two-phase scale-up strategy for the production of DPM.

• Rapid, Seamless Upstream Process Development And Scale-Up For CHO-K1 Cells

  Accelerate your biotech company's scale-up process while delivering consistent and strong cell growth, productivity, and product quality.

• Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing

  This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.

• High-Performance Extraction And Quantitation Of Host-Cell Residual DNA

  This study presents a high-efficiency method for extracting and quantifying residual DNA from host cells using a semi-automated, high-throughput workflow.

• Maximizing Scale-Up Efficiency Of A mAb Upstream Process

  This study demonstrated the effectiveness of a medium and feed system when tested at three different scales for its ability to high-quality, fed-batch monoclonal antibodies.

• Mycoplasma Testing In Monoclonal Antibody Production

  Prevent costly disruptions in your bioproduction process. Discover how a PCR-based method can quickly detect the presence of mycoplasmas in raw materials, cell banks, and in-process and lot-release samples.

• Simultaneous Extraction Of Mycoplasma, MMV, And Vesivirus Nucleic Acids From A Single Sample

  Achieve early detection of cell culture contamination with a nucleic acid extraction system to provide an integrated system for rapid and sensitive detection of mycoplasma, MMV, and vesivirus.

• Residual Plasmid Quantification In Gene Therapy Manufacturing Workflows

  This article details the design and application of a Plasmid DNA - Kanamycin Resistance Gene (pDNA-KanR) kit for residual plasmid quantification in gene therapy manufacturing.

• Optimize T Cell Phenotype With One-Step Isolation And Activation

  This comparative bench-scale study features active-release beads that could improve the reliability, consistency, and longevity of cell therapy treatments.

• Overcoming Rapid Growth Challenges With Process Liquid Preparation

  With a helpful assessment and the right process liquid preparation services, the CDMO featured in this study was able to find a path toward meeting the surge in demand for a client's therapeutic .

• Explore A High-Performing Basal Medium And Feed Pairing

  A customer sought to replace a chemically defined CHO medium with a more efficient medium and feed pairing strategy in bioreactors.