Thermo Fisher Scientific

ABOUT THERMO FISHER SCIENTIFIC

Thermo Fisher Scientific is a leading global provider of cell and gene therapy development solutions. We accelerate your novel therapeutics from clinical development to commercialization. With our comprehensive portfolio of products and services we will be your dedicated partner throughout the development journey.

Key Capabilities:

Plasmid construction, vector production, and purification
Cell isolation, engineering, expansion
Lot release, characterization, and preservation
Formulation, fill, and finish
Expert professional support to meet process, scale, quality, and regulatory requirement

WEBINARS AND VIDEOS

Supply Resiliency For Bioprocessing Amid Global Volatility

Build bioprocessing resiliency with strategic supply chain management. Learn to meet quality, compliance, and time-to-market demands amid global volatility with effective sourcing.
Streamlining Vaccine Purification: Techniques For Modern Modalities

Explore cutting-edge chromatography techniques accelerating vaccine purification across diverse modalities, with case studies on HPV, Malaria, and COVID-19.
Scaling Plasmid DNA Production: A Proven Strategy For Higher Yields

Learn how an agile manufacturing partner scaled their plasmid DNA production and achieved higher yields by optimizing their media selection and fermentation processes.
Next-Gen Disease Models And Cell Therapeutics: Innovations In AI, Omics And Collaboration

Learn how to leverage AI, omics integration, and collaborative research to build more physiologically relevant disease models and accelerate the development of next-gen cell therapies.
Discover The Benchtop DynaDrive Single-Use Bioreactor

Ready to transform your process development? Introducing the 5 L Thermo Scientific DynaDrive Single‑Use Bioreactor (S.U.B.), now available! Experience the same bioreactor design from bench to commercial and re‑imagine scalability in process development.
Efficient Scale-Up Of Monoclonal Antibody Production: From Bench Top To 500L

Scaling monoclonal antibody production from the lab to a commercial scale can be challenging. Learn about an approach that helps you maintain consistent productivity and product quality across all scales.
Achieving High Purity In Complex Antibody Formats

Discover innovative purification strategies and workflow designs for next-generation antibody formats and learn to overcome challenges in achieving high purity and yield.
Enhancing Protein Quality Through Optimized Galactosylation

Advance your understanding of critical protein engineering. Explore expert strategies for optimizing complex molecular structures, paving the way for more effective and consistent biological products.
Global Strategies For Resilience And Redundancy In Cell Culture Media Supply

Ensure your cell culture media supply remains uninterrupted. Explore proactive strategies for global manufacturing equivalency and consistent media delivery.
Tackling Residual DNA Testing In Biotherapy Manufacturing

Controlling residual host cell DNA is critical for the safety and efficacy of biotherapeutics. Learn about robust, highly sensitive analytical methods for effective DNA clearance and process control.
Expanding Manufacturing Of Purification Resins To Align With Customer Demands

Discover how scaling up processes and building out facilities has allowed for end-to-end solutions that meet customer requirements for both supply and quality in their production lines.
Ensuring Quality, Driving Customer Confidence

How does quality assurance help drive scientific progress? A 30-year veteran shares her story of supporting customer needs and the development of groundbreaking new therapeutics.
An Innovative Approach To High Aggregate Challenges

In this webinar, hear from a technical specialist on addressing the challenges with antibody aggregates and process related impurity removal using a new high performance chromatography resins
Enhancing Aseptic Fill-Finish Processes

Achieve exceptional product recovery and sterility. Learn about high-integrity surge bags, advanced leak detection, and flexible design options for your fill-finish applications.
CAR-T Innovation: Balancing Allogeneic And Autologous Cell Therapy

Join experts as they discuss strategies for optimizing allogeneic and autologous therapies, aiming for balanced development and wider patient accessibility by 2030.
Efficient AAV Purification With AAVx And AAV9 Magnetic Beads

Explore an alternative to chromatographic affinity capture that eliminates the need for universal nuclease treatment by utilizing magnetic beads with ligands specific to AAV.
Efficient-Pro Medium And Feed (Why Choose Pro)

Discover an animal-origin-free and chemically defined medium and feed system solution designed to revolutionize your workflow.
Leveraging Rapid Sterility Testing To Advance Cell Therapy Production

Explore the crucial role of rapid sterility testing in cell therapy manufacturing. This presentation delves into the benefits of swift, accurate detection for product quality and patient safety.
Supporting Efficacy And Scaling With A Next-Generation T Cell AOF Formulation Medium

Explore a novel, next-generation medium designed with an animal component-free formulation to boost therapeutic potential and enable reproducible T cells.
Development Of A CHO Medium And Feed System Using Advanced Analytical Tools And Workflow Considerations

Discover how a new, chemically defined cell culture medium and feed system can maximize recombinant protein production in Chinese hamster ovary (CHO) cells, enhancing productivity and streamlining manufacturing.
Microbial Identification Via DNA-Seq

Learn how DNA sequencing-based microbial identification supports regulatory compliance and enhances contamination control in critical environments.
BPI Interviews Purification And Pharma Analytics Leader

Jean Luo, VP of Purification and Pharma Analytics, discusses innovations in bioprocessing, including the development of dPCR assays, lentiviral titer systems, chromatography resins, and supply chain.
CTS DynaCellect Fluidics Demonstration

Streamline and customize your cell processing workflow with automated, precise control over fluid movement and transfer parameters.
Advancing The Purification Of VSV-G Pseudotyped Lentiviral Vector

Discover new strategies to overcome lentiviral purification challenges with a scalable approach that maintains viral infectivity through gentle processing conditions.
AAV Purification: Solving Downstream Challenges

In this roundtable discussion, a trio of distinguished experts in AAV purification and process development share their expertise and best practices in tackling and solving downstream challenges.
Knowledge Culture Basics — Gene Therapy Education Series: Lentiviral Vectors

In this session of our ongoing education series on lentiviral vectors, we delve further into principles of lentiviral transduction and challenges in suspension-based lentivirus production.
Validation Of A qPCR Assay For Host Cell DNA Quantitation

Here, we share the development and validation of a new, highly sensitive and accurate integrated solution for detection and quantitation of host cell DNA to help meet regulatory requirements.
Uninstalling CTS Dynacellect Bead Removal Kit

A detailed walkthrough on how to uninstall the Gibco CTS DynaCellect Bead Removal Kit when the bead removal protocol or the Gibco CTS DynaCellect magnetic separation system is completed.
Advances In Microbial Fermentation Knowledge Culture

Presented by three experts, this session examines real-world examples of how different approaches to media formulation and process conditions can influence outcomes.
Advanced Contamination Control: Automation, Assays, Process Efficiency

Learn how automated closed systems and larger bioprocess containers contribute to maintaining product integrity and how rapid analytical assays can offer reliable and accurate contamination detection.
Knowledge Culture: Downstream Innovation

In this workshop, you’ll learn about various solutions, from cell isolation to cell expansion, that can support autologous and allogeneic cell therapy process needs, digital automation, and mycoplasma testing.
Isolating CD4 / CD8 T Cells For Improved Drug Efficacy, Productivity

Learn how the active detachment of dynabeads from target cells at any time allows users to add flexibility and scalability to their process.
How To Use 5 And 10L BPCs Of The CTS Optmizer Family Of Serum Free Media

Gibco™ CTS™ OpTmizer™ T Cell Expansion SFM, no phenol red, and Gibco™ CTS™ OpTmizer™ Pro SFM are now available in 5 L and 10 L volumes in Thermo Scientific™ BioProcess Containers.
Enhancing AAV Purification In Gene Therapy Manufacturing

Review chromatography solutions for purifying multiple AAV serotypes, with specialists’ insights on bioprocessing and downstream optimization.
Innovation Of Novel Purification Strategies

In this webinar, we present the development of a novel scavenging resin for clusterin, a persistent CHO host cell protein commonly observed in monoclonal antibody manufacturing processes.
Considerations For Affinity Capture In An AAV Platform Downstream Process

This presentation explores the considerations when evaluating a platform affinity capture step for the purification of AAV vectors. Specificity, binding capacity, purity, yield, scalability and reusability are parameters that will be addressed.
Peptones And Vaccines: A Synergistic Approach To Enhanced Production And Efficiency

Enhance your vaccine manufacturing with peptones. Explore their benefits, analyze data-driven productivity gains, and learn integration strategies in this informative, on-demand session.
BioTitan Retention Device Overview

Learn about a retention device that provides robust fortification for single-use assemblies. Its 360-degree seal strengthens connections, reduces leak risks, and ensures process integrity for fluid transfer.
Advancing Gene Therapy Development With A Multi-Serotype AAV Resin

In this webinar, leading CDMO ABL and Thermo Fisher will share data on implementation of the POROS™ CaptureSelect™ AAVX affinity resin into such an AAV purification platform, including its performance in purifying several serotypes.
Maximize Your Drug Product Recovery With A Complete Fill Finish Solution

Discover how to maximize drug product recovery with an end-to-end fill-finish solution. Get excellent integrity assurance and exceptional lead times for your critical processes.
Building A Purification Toolkit For An Expanding Variety Of mAb Therapeutics

Explore techniques for optimizing purification toolkits for various monoclonal antibody formats. This session covers resin and buffer selection for efficient downstream process development.
Rapid Micro Methods In QC Micro Testing: A NIBRT Perspective

Learn about some of the advanced Rapid Micro Method systems that are being adopted by biopharma companies worldwide, and how they are changing the face of QC Microbiological testing.
Simple In-House Mycoplasma Testing Method For Regulatory Expectations And Rapid, Confident, And Actionable Results

In this webinar, we present an overview of worldwide regulatory guidance for mycoplasma testing, as well as a mycoplasma testing method that has been accepted by regulatory authorities worldwide across various therapeutic modalities.
Analytical Approaches For Quantifying Residual Host Cell DNA

In this webinar, we’ll discuss the challenges, risks and considerations involved in developing and using in-house residual testing solutions, and the benefits of using commercial kits for residual DNA testing.
Key Considerations For Rapid Microbial Methods For Mycoplasma Detection

Learn the importance of demonstrating product specific suitability, defining representative sample, consistent sampling protocols, accommodating volume and turnaround time constraints, and the need to establish equivalence.
A Successful Journey To Cell Therapy Manufacturing

Learn about the three main areas to consider when you're preparing to commercialize a cell therapy, including starting/raw material, the controlled manufacturing process, as well as testing safety and quality.
CHO Solutions Day Part 1

This CHO Solutions Day presentation offers valuable insights into new media and feed systems, a successful scale-up story, and how multi-omics analysis can enhance your cell culture.
CHO Solutions Day Part 2

Discover how to optimize your CHO process with key insights from CHO Solutions Day. Learn about the importance of tracking viable cell volume, using flexible media, and leveraging a harmonized manufacturing network.
Leveraging dPCR r Techniques To Quantitate Lentivirus Particles

Discover how digital PCR can streamline lentiviral vector characterization to reduce variability and improve analytical sensitivity. Learn how this approach can help you comply with regulatory guidance.
Cell Therapy Bioprocessing Workflow Cinematic

Witness a seamless cell therapy bioprocessing workflow that reduces manufacturing time and preserves the crucial cell phenotype for scalable, effective autologous and allogeneic therapies.

CONTACT INFORMATION

Thermo Fisher Scientific Bioproduction

7305 Executive Way

Frederick, MD 21704

UNITED STATES

Contact: Hunter Tuck

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BROCHURES

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FEATURED ARTICLES

Molecular Approaches To Streamline Cell Therapy Product Analytical Testing

Learn how rapid molecular methods of cell therapy testing like qPCR for mycoplasma, sterility, and lentiviral quantification are key to accelerating product release and timely treatment delivery.
Advances In Analytical Method Selection And Technology Transfer

Successful analytical method transfer is crucial for product quality and regulatory compliance. Learn best practices for tech transfer, including how gap assessments mitigate common risks and streamline bioprocessing.
Streamlining Data For Efficient Therapeutic Manufacturing

An integrated solution for impurity and sterility analysis streamlines data, supports regulatory compliance, and uses built-in algorithms to deliver accurate, actionable results quickly.
Select The Best Analyte: A Guide To Effective Mycoplasma Testing

As you build a Mycoplasma testing strategy to ensure drug safety, there are three analyte types to choose from: live Mycoplasma, RNA, and genomic DNA, each offering distinct advantages.
A Paradigm Shift From Glass Benchtop Bioreactors

Learn how a bench-scale single-use bioreactor offers process development advantages over traditional glass systems, including higher efficiency, increased productivity, and enhanced sustainability.
Scalability From 5L To 50L Using The DynaDrive Single-Use Bioreactor

Maintaining a consistent bioprocess when scaling from 5 L to 50 L is achievable. This study shows how to successfully scale processes while maintaining cell density, viability, and protein production.
Consistent Improvement In CHO-K1 GS Performance With Efficient-Pro Feed 3 And Efficient-Pro Feed Enhancer

Optimize your CHO-K1 GS cell line with advanced chemically defined, animal origin-free feeds. Achieve higher titers and reliable product quality.
The Value Of Peptones For Cost-Effective Vaccine Manufacturing

Peptones offer a strategic solution to key biomanufacturing challenges by enhancing cell culture performance, improving yields, and reducing production costs.
Improved T Cell Expansion Using Closed, Automated Stirred-Tank Bioreactors

A shift from traditional rocking motion systems to stirred-tank bioreactors can enhance T cell expansion, offering greater scalability and more intimate process control.
Comparing Serum-free To Serum-Supplemented Media

Reducing serum in vaccine manufacturing is a key consideration for lowering costs and improving supply security. We compare performance in serum-free versus serum-supplemented media.
A Temperature-Stable Replacement For Animal Trypsin In Cell Dissociation Applications

Improve cell dissociation with a gentle, recombinant enzyme. This temperature-stable protease shows dissociation kinetics similar to porcine trypsin but with lower cell toxicity and greater overall purity.
Streamline Your mAb Manufacturing With Strategic Development And CDMO Compatibility

Though the journey to mAb development begins at lab scale, for clinical trials and commercial distribution, a production process must be streamlined and scalable to 2,000 L production and above.
The Role Of Peptones In Boosting Monoclonal Antibody Production

Peptones have become a key tool in CHO cell bioprocessing, enhancing monoclonal antibody yield and quality.
Optimize Your Approach To mAb Development

To meet the growing demand for mAbs and their variants, it is important to leverage opportunities for optimization as well as work with suppliers that have the resources to help your workflow thrive.
Finding An Optimal Harvest Solution By Considering Both Cost And Sustainability

Optimize your bioprocessing harvest with single-use centrifugation. Reduce costs, waste, and space needs compared to traditional depth filtration methods.
Single-Use Technology And Environmental Responsibility In Biopharmaceuticals

Learn about strategies such as regional manufacturing and advanced single-use systems and their potential to minimize carbon footprint and enhance sustainable biomanufacturing.
Scale-Up Approaches For Culturing Adherent Cells

For successful scale-up, see how optimizing process parameters such as attachment methods, gassing, and agitation can help reduce cell environmental stress, ultimately improving productivity.
Comparison Of Single-Use And Steel Fermentors For Malaria Vaccine Production

Support the advancement of malaria vaccine development by leveraging innovative bioprocessing solutions to enable efficient, scalable, and accessible vaccine production worldwide.
Intuitive Bioprocess Scale-Up From Bench Scale To Pilot Scale

This study explores scaling a high-demand fed-batch process from bench to pilot scale, highlighting control parameter differences at 50L and 500L while maintaining consistent growth and product titers.
Advances In Flow-Through Technology To Enhance mAb Polishing

Optimize your monoclonal antibody purification with cutting-edge flow-through chromatography. Learn how POROS resins enhance polishing efficiency, improve aggregate removal, and streamline bioprocessing.
The Importance Of Quality In Raw Material Selection

Learn how to select high-quality raw materials for cell-based manufacturing in this exploration of the criticality of raw materials, from preclinical development to commercialization.
Enhanced mAb Production With High-Intensity Perfusion CHO Medium

Reach new heights in mAb production with a high-intensity perfusion CHO medium designed to support consistently high product yield and quality in continuous perfusion cultures using CHO-K1 cells.
The Value Of Peptones For Enhancing Biopharmaceutical Productivity

Peptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.
Difco TC Yeastolate Ultra-Filtered (TCY UF) In Scale-Up Optimization

Explore how Difco™ TC Yeastolate ultra-filtered (TCY UF) enabled over 100% improvement in titer for CHO cell culture through feed optimization and bioreactor scalability in a real-world application.
Production And Clarification Of Lentiviral Vectors

Explore scalable processes for lentiviral vector production and clarification at the 50 L scale, utilizing the CTS LV-MAX system and single-use bioreactors for robust gene therapy manufacturing.
Ensuring Product Safety And Purity With Mycoplasma And Sterility Testing

Discover how the Applied Biosystems™ MycoSEQ™ Plus system and Applied Biosystems™ SteriSEQ™ Rapid Sterility Testing System can help accelerate your cell therapy manufacturing process.
Achieving Titer Increase Up To 4-Fold While Maintaining Product Quality

Discover customizable solutions for antibody manufacturing, as well as services for media optimization, feeding strategy optimization, and format conversion.
Development To Large-Scale cGMP Production

For manufacturers working with a dry powder medium (DPM), early consultation with a supplier can increase the likelihood of success. Uncover a two-phase scale-up strategy for the production of DPM.
Rapid, Seamless Upstream Process Development And Scale-Up For CHO-K1 Cells

Accelerate your biotech company's scale-up process while delivering consistent and strong cell growth, productivity, and product quality.
Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing

This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.
High-Performance Extraction And Quantitation Of Host-Cell Residual DNA

This study presents a high-efficiency method for extracting and quantifying residual DNA from host cells using a semi-automated, high-throughput workflow.
Maximizing Scale-Up Efficiency Of A mAb Upstream Process

This study demonstrated the effectiveness of a medium and feed system when tested at three different scales for its ability to high-quality, fed-batch monoclonal antibodies.
Mycoplasma Testing In Monoclonal Antibody Production

Prevent costly disruptions in your bioproduction process. Discover how a PCR-based method can quickly detect the presence of mycoplasmas in raw materials, cell banks, and in-process and lot-release samples.
Simultaneous Extraction Of Mycoplasma, MMV, And Vesivirus Nucleic Acids From A Single Sample

Achieve early detection of cell culture contamination with a nucleic acid extraction system to provide an integrated system for rapid and sensitive detection of mycoplasma, MMV, and vesivirus.
Residual Plasmid Quantification In Gene Therapy Manufacturing Workflows

This article details the design and application of a Plasmid DNA - Kanamycin Resistance Gene (pDNA-KanR) kit for residual plasmid quantification in gene therapy manufacturing.
Optimize T Cell Phenotype With One-Step Isolation And Activation

This comparative bench-scale study features active-release beads that could improve the reliability, consistency, and longevity of cell therapy treatments.
Overcoming Rapid Growth Challenges With Process Liquid Preparation

With a helpful assessment and the right process liquid preparation services, the CDMO featured in this study was able to find a path toward meeting the surge in demand for a client's therapeutic .
Explore A High-Performing Basal Medium And Feed Pairing

A customer sought to replace a chemically defined CHO medium with a more efficient medium and feed pairing strategy in bioreactors.
Buffers And Process Liquids For Biopharmaceutical Production: Considerations For Scale-Up And Outsourcing

For small and midsize biopharmaceutical organizations, outsourcing buffer and process liquid preparation, quality testing, and storage could significantly streamline operations and reduce regulatory risk.
Advancing Cell Therapy Manufacturing: Rapid Sterility Testing

The rapid sterility test kit used in the study was able to quickly detect bacteria and fungi in complex cell therapy product matrices, detecting six species listed in USP chapter <71>.
Screening Peptones, Including "Titration And Blending" Protocol Examples

Dive into the importance of peptone selection, instructions for reconstituting peptone powders for mammalian cell culture, and discover starter packs containing commonly used peptones for specific applications.
Enabling CDMOs To Focus On Core Priorities

Explore innovative solutions for CDMO's striving to remain competitive as the biopharmaceutical market grows and evolves.
Enhanced T Cell Expansion While Maintaining Early Memory Cell Phenotype

Study the development and performance of this animal origin-free (AOF) T cell culture medium designed for T cell expansion through an experiment comparing it to other AOF or xeno-free basal offerings.
Uninterrupted Supply To Meet Demand

Explore a solution for biopharmaceutical companies concerned about the risks an increase in campaign volume can pose to their production timeline.
cGMP Assurance of Supply Services

Explore the stocking solution offered to a mid-sized CDMO in need of a high volume of safety stock inventory to support their customer portfolio growth.
Exploring The Future Of Viral Vector Development And Production

The demand for viral vectors continues to grow, making addressing the challenges related to their manufacturing and scale-up increasingly critical.
Achieve Manufacturing Scale For Your Viral Vector Production

Elevate your viral vector production to commercial scale by choosing the optimal production system paired with the right single-use bioreactor combination.
Production And Purification Of AAV At The 50 L Scale

Explore data demonstrating the performance of a scalable system for AAV manufacturing that enables gene therapy researchers to utilize a single system throughout the entire development process.
Compatible Platforms For Microbial Identification

Reduce the time-to-results for microbial identification by taking advantage of the shorter run cycle and off-instrument data analysis provided by this optimized and validated workflow.
Rapid Mycoplasma Detection For Bioproduction Sample Testing

Streamline your workflow while enabling early and accurate detection of mycoplasma contamination with mycoplasma detection and sample preparation kits