FEATURED ARTICLES

• Efficient-Pro Medium And Feeds Improve Productivity In CHO-K1, CHO-S, And DG44 Cells

  We demonstrate an innovative and commercially available platform that can enhance process productivity and reduce your development time, thereby enabling potential reductions in manufacturing costs and accelerating a product’s time-to-market.

• Single-Use Solutions For Research And Process Development

  Can supply chain assurance be maintained while offering an array of possibilities to achieve complex process designs? Learn if your organization could benefit from a modularized and standardized single-use manifold design.

• Reducing Risk During CAR T Cell Therapy Development And Manufacture

  It is essential to identify potential areas for optimization early in CAR T cell therapy development—particularly with respect to equipment, reagents, and analytics.

• Diploid Serum-Reduced Medium System Supports Viral Production

  Results demonstrate that the system can enable vaccine manufacturers to reduce the use of FBS while achieving potential increases in viral specific productivity with diploid cells.

• Reduce Or Eliminate Serum Use In Vaccine Production

  The use of this Diploid Growth Serum-Reduced Medium (SRM) helps vaccine manufacturers using diploid cells meet their production forecasts while reducing production costs and serum use.

• Improving Allogeneic Workflow And Cell Proliferation Using CTS OpTmizer Pro SFM

  This application note outlines the capabilities of CTS OpTmizer Pro SFM compared with a control medium in both diseased patients’ and healthy donors’ cells.

• Human Regulatory T Cell Expansion And Measurement Of Function

  Regulatory T cells (Tregs) are a subpopulation of T cells with the unique ability to suppress the activation of effector T cells and thereby prevent T cell function. This application note describes an optimized protocol for activation and expansion of flow-sorted Tregs with Gibco™ CTS™ Dynabeads™ Treg Xpander.

• One-Step Isolation And Activation Of Naive And Early Memory T Cells With CTS Dynabeads CD3/CD28

  In this application note we demonstrate nearly 100% recovery of naive and early memory T cells using Gibco™ CTS™ Dynabeads™ CD3/CD28 beads. This one-step process of simultaneous T cell isolation and activation yields pure and uniformly activated T cells.

• Understanding Perfusion Terminology

  Over the past several years, perfusion has become an increasingly attractive process for development in the biopharmaceutical industry. To fully evaluate whether a perfusion application will work in a production process, it is critical to have standardized terminology. This white paper explains key terms that are essential for understanding the process.

• Outsourcing Trusted-Weight Dry Powder Chemicals To Support Expansion

  The gene therapy division of a major pharmaceutical manufacturer was looking for ways to overcome capacity constraints due to the increased production demands for process liquids and buffers. Non-core manufacturing activities, including the weigh and dispense steps in the process liquid and buffer preparation, were identified as bottlenecks impacting the overall production schedule. The proposed solution would provide ready-to-hydrate, trustedweight dry powder chemicals. Read how the customer benefited from the procurement of larger lot sizes that were not capable of being handled within their facility, resulting in annual savings for raw materials and QC testing.