
ABOUT DANAHER LIFE SCIENCES
Every day, scientists around the world are dedicated to unraveling the mysteries of disease, discovering novel therapies and vaccines, and conducting crucial drug testing. At Danaher Life Sciences, a collection of businesses within Danaher Corporation, we play a pivotal role in facilitating these cutting-edge scientific endeavors. Our comprehensive capabilities go beyond research, enabling us to drive the development of innovative biopharmaceuticals, revolutionary cell and gene therapies, and other breakthrough treatments that propel patient health forward and enhance treatment outcomes.
FEATURED ARTICLES
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Explore how a streamlined, EAD-based middle-down workflow can achieve consistent high sequence coverages of mAb subunits and confident PTM analysis in a single injection.
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View a study which provides additional insight into the factors that govern the discoloration of protein therapeutics and the role of AGEs in color change.
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How can a single-injection, EAD-based middle-down workflow leverage accurate mass measurement, information-rich EAD fragmentation and automated data analysis to offer confident sequence confirmation.
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In this study, a system with multi-capillary capabilities was used to analyze etanercept by bapillary electrophoresis-sodium dodecyl sulfate (CE-SDS).
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Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.
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Explore a workflow used to determine the molecular weight and analyze the purity of a 70-mer DNA sequence with a 3’ dT overhang.
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Develop a fast, easy workflow for the purity analysis of complex pegRNA molecules along with a robust denaturing technique for pegRNA with high levels of secondary structure.
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Establishing an integrated, tailored data management strategy is core to getting the cell line development journey right.
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Gain a deeper understanding of how EAD is used when characterizing ALC-0315 and its impurities, as well as identify the nature and site of chemical alterations in ALC-0315 resulting from forced degradation.
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Review the development of an LC-MS method for the reliable identification and relative quantification of different mRNA capping structures.
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A test conducts on a novel fragmentation mode for the detailed characterization of lipids, reveals information that can be used to determine drug efficacy and safety from formulated LNPs.
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Explore how the peptide mapping workflows templates provided by a software designed for the characterization of biotherapeutic digests alongside data visualization and interrogation.
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For cell line development, much of a workflow’s success hinges on how much analytical data a team can get – and how quickly – to inform their process.
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Learn about the details surrounding the comprehensive mapping of disulfide linkages in etanercept using the EAD approach on an analytical characterization system.
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Examine a comprehensive analysis of deglycosylated NISTmAb (dgNISTmAb) using a novel integrated icIEF-UV/MS workflow.
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What are the results of an innovative system for direct chip-based integration of icIEF with mass spectrometry (MS) being utilized to characterize mAbs spanning a wide pl range?
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A newly integrated and easy-to-use peptide mapping workflow for the analysis of standard monoclonal antibodies provides a streamlined workflow for the analysis of both CID and EAD data.
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Explore the benefits of an electron-activated dissociation middle-down workflow, including the ability to achieve high sequence coverages (70%-80%) of monoclonal antibody subunits in a single injection.
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Improve your cloning efficiency with higher assurance of clonality by using a combination of single-cell isolation and microplate imaging.
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Review an in-depth study of the automation of a mammalian cell-line development workflow—the automated, integrated screening of transfected cells for edits, monoclonality, and growth assessment.
CONTACT INFORMATION
Danaher Life Sciences
500 Old Connecticut Path
Framingham, MA 01701
UNITED STATES