Custom Antibody Development And Characterization Services

With an industry-leading dedication to quality, we deliver high-performance reagents that work as you need them to and perform consistently over time.

We deliver high-performance antibodies at scale to give you confidence in your results and help progress your research. We partner with you at every stage of your discovery and development process, working as an extension of your in-house team, to design and develop antibodies that support your project from early research through to the clinic.

Why work with us?

• Our teams have decades of experience in antibody discovery, immunogen design and immunization strategies alongside specialists in protein development, assay development, immunohistochemistry (IHC), and more. Working with our team of experts means that your project is in the best possible hands.
• We focus on tailored campaigns with careful risk mitigation, using data-led insights to ensure results-based progression at critical decision points
• You’ll gain access to our network of partners, including diagnostic developers and GMP manufacturers, providing a seamless transition from development through to commercialization
• With access to the global research community, we can independently validate your reagent, build on your results, and provide a foundation for market adoption for your target
• We offer flexible platform selection with evolving technologies:
  • Multiple immunogen approaches and immunization strategies
  • Predictive bleed titres for target IgG/ IgM response and animal selection
  • Target enrichment and selection/ deselection of B-cells
  • Straight-to-clone hybridoma process
  • High-throughput recombinant conversion for unique hit identification
  • Single B-cell cloning
  • Extensive target scoping
  • Personalized screening cascade, characterization and validation plan

Why recombinant rabbit monoclonal antibodies?

• Antibody Diversity: Two affinity maturation mechanisms in rabbits lead to a more diverse set of epitopes and high sensitivity, so there’s a greater chance of finding antibodies to challenging targets
• Cross-reactivity: Rabbits are evolutionarily distant meaning greater chance of cross-reactivity across Human- Mouse-Cyno antigens to allow for seamless transition from animal to human models in preclinical studies

"Know-how" and continuous innovation:

Focus on quality

• Recombinant production for security of supply and consistent antibody performance
• Antibody engineering for flexibility of species backbone and multiplexing options
• Variety of formulation and conjugation options for “ready-to-use” reagent
• Extensive validation in wide range of applications, including IHC, live cell flow cytometry, functional assays and pair development tailored to your specific end-use requirements
• Knock-out testing using in-house CRISPR-Cas9 edited cell lines
• Sensitivity - off-rate ranking of candidate antibodies on Octet-BLI
• Multiclonal development (polyclonals made from a mixture of recombinant monoclonal antibodies for consistent results each time)
• Biophysical characterization for ultimate batch-to-batch consistency