FEATURED ARTICLES

• How CDMOs Have Become Emerging Technology Influencers

  Learn how CDMOs fill the gap between cutting-edge science and the commercial sector of cell-and-gene therapeutics by partnering with the best technology providers to maximize the manufacturing process.

• Allogeneic Cell Therapy: What Options Do Sponsors Have To Scale Their Product?

  Explore some automated scale-up solutions and how you can design and execute your allogeneic cell therapy seed chain from phase 1 onward.

• Upstream Manufacturing: Is An Open Or Closed System Better?

  Explore some factors to consider when making the critical decision on whether to use an open or closed system for the bioprocess manufacturing process.

• Extracellular Vesicle Production, Characterization, And Quantification Methods

  While extracellular vesicles represent significant opportunity for the biologics space, researchers are still building a foundation of knowledge surrounding their biology, application, and ultimate value.

• Fixed-Bed Reactor System For Expansion Of Human Embryonic Stem Cells

  Regenerative medicine company ViaCyte Inc. explored new technologies to enable expanded scales of culturing hESCs for development of cell replacement therapies as a functional cure for Type 1 diabetes.

• How Collaborative R&D Revolutionized Adherent Culture Scale-Up

  The Corning Ascent FBR System can ease or eliminate therapy developers’ difficult choice between adherent and suspension cell culture platforms when scaling production.

• Gene Therapies: From Research To Reality

  Partnership scrutiny is critical for cell and gene sponsors transitioning from pure R&D and early preclinical work into clinical-phase development.

• Helping MEARY Center Paris Advance Personalized Medicine

  Learn what solutions Paris University Hospitals Consortium’s core facility for cell and gene therapy is using to isolate and expand mesenchymal stromal cells.

• An Easy-To-Use Bioprinter For 3D Cell Culture

  Read how culture dispensed by a bioprinter are suitable for further molecular and protein analysis as well as downstream applications including high throughput drug screening.

• Mechanical Movement EVokes Increase In Extracellular Vesicle Production

  We demonstrate a 12-layer cell culture vessel can be used to produce seven trillion high quality EVs from mesenchymal stem cells (MSCs).

• A Novel Approach To Type 1 Diabetes Treatment

  With the combination of a viral vector platform and a fixed bed bioreactor platform, a lab is working on a curative gene therapy that could address and possibly reverse T1D's underlying mechanisms.

• From Bench To Billions: Facilitating Scale-Up Of Adherent Cultures For Cell And Gene Therapies

  We review what researchers should consider when they are creating a risk-mitigating adherent culture process for cell and gene therapy scale-up.

• The Race To Billions: How Amplifying Adherent Cultures Can Get You There

  Industry experts discuss platforms for adherent cell culture scale-up, how to trim time and costs, and how to deliver high-efficiency output across adherent applications.

• Optimizing Stem Cell Production With Modern-Day Lab Technologies

  Read about the ample new tools and technologies in the lab available to scientists to support those MSC workflows for improved scale and cell quality.

• Harvest Of 36-layer Vessels Using Automated Manipulator System

  We demonstrate by automating the handling of multiple vessels during critical liquid handling steps, the manipulator platform simplifies fill, empty, and harvest steps for a more reproducible process.

• Comparing Gene Transfer Tools: Adeno-Associated Virus And Lentiviral Vectors

  We review the advantages, disadvantages, and scaling considerations of adeno-associated virus (AAV) and lentivirus (LV) vector gene transfer mechanisms.

• Cell Suspension Or Adherent Cell Surface: Which Method Is Right For Your Lab?

  We review what to consider when selecting an adherent or a suspension platform for your cell culture method to achieve the best growing conditions.

• Exploring What’s Possible With Stem Cell Therapies

  Explore the changing landscape of stem cell research and cell therapy production and read how emerging solutions have facilitated a new era of more effective and efficient workflows.

• Why Are MSC-EVs Important And How Can You Scale-Up?

  Read how with more efficient and consistent production methods, researchers will be able to maximize the full potential of EVs for research and therapeutic application.

• Lessons Learned: An Inside Look At Overcoming Stem Cell Therapy Scale-up

  Dr. Carolyn Wrightson shares some of the valuable lessons and considerations she and her team learned about stem cell therapy scale-up and optimization.