Corning® Ascent® Fixed Bed Bioreactor System

Improve Scale-up of Adherent Cells for Bioproduction

A major challenge for manufacturing adherent cells for advanced therapies is producing the large quantities of cells needed in a cost-effective manner. To address the need for a more efficient solution, Corning developed the novel Ascent FBR System, a fixed bed bioreactor system designed to combine the benefits of adherent bioproduction platforms with the scale and automation of suspension manufacturing systems.

• Features an innovative bioreactor designed to enable uniform media flow and uniform high-density cell growth.
• Demonstrated to achieve greater than 90% transfection efficiency and high AAV-GFP vector yield/m², which can reduce required runs and result in substantial cost savings.
• Enables viable cell harvests for seed train and total viral particle capture and a path for other applications, such as stem cell therapy workflows
• Multiple Ascent FBR formats, from a 1 m² benchtop system to 1,000 m² production system, are planned to help create a stable and well-defined manufacturing process
• Allows for the use of chemical (detergent) or mechanical (freeze/thaw, microfluidization) cell lysis methods for the release of cell-associated viral vectors