product datasheets, catalogs, app notes

  1. EX-CELL® CD Insect Cell Medium 3/29/2022

    A chemically defined medium specially formulated to get the best performances for insect cell lines. The formulation is animal-component free and has been formulated with L-Glutamine.

  2. Sf-RVN® Insect Cell Line 3/29/2022

    The Sf-RVN® Insect Cell Line is a rhabdovirus-negative Sf9 cell line that can be grown in both adherent and suspension culture.

  3. AAV Process Development Guidance Based On Cost Modeling 3/16/2022

    Cost modeling can be a powerful tool to assist with prioritizing areas of focus for process improvement during process development and especially useful for processes producing viral vectors for gene therapies.

  4. Multivariate Inter-Stage Batch Profile Monitoring And Future State Estimation 2/3/2022

    How much quicker and easier would it be if we could know the process’s health by looking at a single metric rather than checking hundreds of parameters?

  5. MilliporeSigma Gene Therapy Capabilities 9/22/2021

    You’ve created a gene therapy with the possibility to help patients. But the development and manufacturing of your gene therapy, how it’s developed, produced and approved, are still being outlined. No process template exists. Our products and services for AAV, Lentivirus and other viral vectors provide solutions to your most challenging pain points around process development, speed, manufacturing and regulatory guidelines.

  6. Stemline® Platform Media – For Optimized Stem Cell Expansion 9/7/2021

    To obtain enough cells for stem cell-based therapies, ex vivo expansion is utilized to ensure successful engraftment and economize the manufacture of both allogeneic and autologous therapies. We have developed the Stemline® Platform of cGMP-manufactured media, optimized for the expansion of various adult stem cell types in automated manufacturing environments.

  7. CellPrime® rAlbumin 8/25/2021

    CellPrime® rAlbumin is a non-animal origin (NAO) recombinant media supplement that is GMP manufactured according to EXCiPACT™. It combines excellent quality with superior performance and  lot-to-lot consistency.

  8. Optimization Strategy And Process Economics Of DNA Digestion In Viral Vector Production For Gene Therapy 12/16/2020

    Benzonase® endonuclease is a high-quality product delivering immense value to viral vector processes. The enzyme activity is strongly influenced by the matrix, and optimization of its use should be a mandatory step in process development. In this application note, we highlight an optimization strategy and process economics of DNA digestion in viral vector purification.

  9. Tangential Flow Filtration (UF/DF) Of Plasmid DNA 12/16/2020

    Learn how optimization of hydraulic parameters can help you achieve the desired plasmid purity, formulation, and concentration specifications.

  10. Sterilizing Grade Filtration Unit Operations For Plasmid DNA Processes 11/19/2020

    The large size of pDNA can present a challenge for sterile filtration unit operations within your gene therapy manufacturing since the product can be retained by the filters, leading to both yield loss and low filtration capacity. Optimization of a sterilized grade filtration unit can help increase yield and filtration capacity. Read on to learn more!