Newsletter | October 7, 2025

10.07.25 -- Sanofi's Digitalization Road Trip Shifts Into High Gear

SPONSOR

Worried about HEK293 residual DNA in your biotherapeutics?

Struggling with residual HEK293 DNA contamination? Bio-Rad’s Vericheck ddPCR HEK293 Residual DNA Detection Kits deliver high specificity, unmatched reproducibility, and an extraction-free workflow to detect and quantify HEK293 DNA with confidence. Access our infographic and eBook to see how it stacks up against traditional methods, and upgrade your QC today. Download now.

FOCUS ON MANUFACTURING

Sanofi's Digitalization Road Trip Shifts Into High Gear

The company's head of manufacturing discusses their latest investments in AI and automation, plus offers tips on how any company can start adopting advanced technology.

Resolving Common Single-Use Concerns

Demand for single-use production tools, components, expertise, and capabilities continues to grow as innovative cell therapies evolve. However, concerns and misconceptions abound regarding single-use solutions.

CAR Expression Detection Using Fluorescent Labeled Proteins, Flow Cytometry

Learn how site-specific fluorescent labeling addresses key challenges in flow cytometry-based evaluations by enhancing assay sensitivity, reducing variability, and ensuring reliable results.

A New Transfection System Tailored For Optimized AAV Production

In AAV manufacturing, long-term success depends not just on titers, but on maximizing the percentage of full capsids to ensure efficacy, safety, and scalability.

Smarter Cell Washing And Pre-Formulation For Allogeneic Therapies

Avoid common pitfalls in cell washing and pre-formulation, including incomplete contaminant removal, manual handling, and throughput issues that compromise product quality and efficiency.

A Digital Solution Embeds Quality Into Cellular Therapeutics Production

Explore how Dendreon cut review and release time by nearly 50% while maintaining a 99% right-first-time rate, which boosts collaboration, visibility, and operational efficiency across teams.

Assuring Multipotency Of Human Mesenchymal Stem Cells (hMSCs)

Stem cell research has revolutionized tissue repair and regenerative medicine. Discover how mesenchymal stem cells play a key role and offer insights into tissue repair, immune response, and inflammatory diseases.

Instant PAT Implementation Across Cell Lines, Media, And Scales

Uncover how MAVERICK’s Raman-based technology delivers instant, reliable measurements of glucose, lactate, and biomass across diverse cell lines, media, and scales.

Next-Generation Cell Therapy: Eliminating Thermal Shock In Electroporation

Conventional electroporation methods struggle with damaging heat buildup. See how innovative flow technology leverages physics to protect cells and enable large-scale therapeutic production.

Driving Innovation In Decentralized Manufacturing

Unlock the potential of localized manufacturing and see how cutting-edge technology is transforming access to essential medications, ensuring patients get what they need.

Transforming Life Science With Remote Equipment Monitoring

Life science organizations are shifting to data-driven oversight, as a result, remote monitoring technologies are revolutionizing operational efficiency and innovation.

DNA Purification From PCR Or Agarose Gels

This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.

The Challenges Of Taking Novel Cellular Therapies To Commercial Scale

Review the ISCT conference in Vancouver, featuring lectures by Dr. Matthew Hewitt and David Brochu, to learn more about advancements and challenges in cell and gene therapy.

MANUFACTURING SOLUTIONS

Challenges In Scaling Allogeneic Processes - Entegris, Inc.

CO2 Incubator: MCO-80ICL-PA - PHC Corporation of North America

AAV Viral Titer And Empty-Full Capsid Ratio Measurement With A Single Assay - Bio-Rad Laboratories, Inc.

Daikyo Crystal Zenith® Ready-To-Use Nested Vials - West Pharmaceutical Services, Inc.

Optimizing Virus Bank Manufacturing - MilliporeSigma

SPONSOR

Join Cell & Gene Live on October 16 at 11am ET for a virtual panel discussion on Designing Early Manufacturing for Long-Term Success in CGT. Registration is free with support from Thermo Fisher Scientific.

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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