Resolving Common Single-Use Concerns: Shaping Innovative Solutions For Cell Therapies

By Evan Hagen, Charter Medical, LLC

When cell therapies emerged more than a decade ago, solutions providers considered them more of a small, niche market, and therefore tended to invest resources in other areas. Manufacturers often repurposed tools from other industries for their cell therapy processes. Single-use solutions are a tool that has evolved to meet the unique challenges of these therapies.

Today, demand for specialized single-use production tools, components, expertise, and capabilities continues to grow as innovative cell therapies evolve. Often, organizations begin the cell therapy journey with benchtop-level experiments in the lab. Eventually, drug developers need more suitable containers for the development of a process designed for clinical production. As they scale up or out, many organizations turn to single-use solutions.

However, concerns and misconceptions abound regarding the use of single-use solutions. A poll conducted during a recent Cell & Gene: Live event, Scaling Cell Therapies: Auto vs. Allo, asked participants to rate their most significant concerns associated with single-use solutions. This article discusses the source of those concerns and ways to overcome them.