Instant PAT Implementation With Raman-Based MAVERICK Across Cell Lines, Media, And Scales

Efficient monitoring and control of critical process parameters (CPPs) such as glucose, lactate, and biomass are essential for optimizing cell culture conditions, ensuring high product quality, and maximizing yield in bioprocesses. Traditional Raman spectroscopy, while powerful, often demands extensive setup, expert configuration, and iterative modeling, making it a complex and costly option.

In this application note, we introduce MAVERICK™, a groundbreaking in-line Raman-based process analytical technology (PAT) that simplifies and accelerates the monitoring of these critical parameters across various CHO and HEK293 cell lines, media formulations, and bioreactor scales. Unlike conventional systems that rely on extensive calibration and model development, MAVERICK utilizes a de novo algorithm designed to handle the generalizable chemistries found in chemically defined cell culture media. This innovative approach allows for instant implementation and real-time monitoring within approximately 60 minutes.

We demonstrate MAVERICK’s robust performance and versatility across multiple bioprocesses, showing its capability to deliver accurate real-time measurements of glucose, lactate, and biomass. Access the full application note to see how MAVERICK can streamline PAT deployment, reducing both time and costs while enhancing bioprocess efficiency.