ABOUT US
Repligen is a bioprocessing-focused life sciences company bringing over 40 years of expertise and innovation to our customers. We are inspiring advances in bioprocessing through the development and commercialization of high-value products and flexible solutions that address critical steps in the production of biologic drugs, principally monoclonal antibodies.
Repligen headquarters is in Waltham, Massachusetts and our manufacturing facilities are located around the world. We market our products globally through a direct commercial organization in the U.S., Europe and Asia, as well as through strategic partners in select markets.
UPSTREAM BIOPROCESSING
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Perfusion cell culture technology supports high cell densities and product yields for viral vaccine manufacturing, offering a reliable way to produce high-quality cells at a commercial scale.
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The demand for complex biologics is driving the need for intensified cell culture technologies. Perfusion using ATF has emerged as a leading solution to increase cell density and productivity.
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Learn about innovative cell retention technology that supports continuous bioprocessing through perfusion cell culture, allowing for longer run times, higher product yields, and reduced costs.
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Discover how TFDF-based perfusion technology boosts lentiviral vector production by over 10-fold, slashes costs, and accelerates the commercialization of CAR-T and other advanced cell therapies.
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N-1 perfusion enables higher inoculum densities, faster production, and reduced costs without altering fed-batch processes. Explore a practical path to intensification for biologics manufacturers.
DOWNSTREAM BIOPROCESSING
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Learn how small UF/DF decisions can create major scale-up challenges, as well as practical ways to improve membrane selection, reduce manual operations, and boost PD–MSAT alignment.
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Enable consistent performance in ultrafiltration, diafiltration, and microfiltration with hollow fiber modules that offer robust construction and a wide range of sizes to meet shifting demands.
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Gain real-time visibility into critical process parameters with in-line measurements that reveal details traditional sensors miss. See how this versatile design supports labs through production.
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Discover an automated TFF platform for small volumes that streamlines filtration steps with fast setup, low hold-up volume, and consistent performance. Ideal for teams aiming to improve efficiency.
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Antibody-drug conjugates offer targeted cancer treatment with reduced toxicity. Discover how single-use technologies simplify ADC manufacturing to ensure safety, flexibility, and efficiency.
FLUID MANAGEMENT
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Discover how to prepare 10x PBS using an innovative system to ensure scalable, efficient, and consistent buffer preparation for large-scale workflows.
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Engineered for biotech and biopharma, discover a single-use mixer that uses advanced technology to deliver scalable, sterile, and efficient mixing for critical cleanroom applications.
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Learn more about a single-use film that is engineered for durability and minimal extractables to enhance efficiency, reliability, and product quality across diverse applications and environments.
CONTACT INFORMATION
Repligen
41 Seyon Street, Building 1, Suite 100
Waltham, MA 02453
UNITED STATES
Phone: 781-250-0111
SOLUTIONS
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Enable consistent performance in ultrafiltration, diafiltration, and microfiltration with hollow fiber modules that offer robust construction and a wide range of sizes to meet shifting demands.
-
Gain real-time visibility into critical process parameters with in-line measurements that reveal details traditional sensors miss. See how this versatile design supports labs through production.
-
Discover an automated TFF platform for small volumes that streamlines filtration steps with fast setup, low hold-up volume, and consistent performance. Ideal for teams aiming to improve efficiency.
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Meet the first bench scale TFF system built specifically for cGMP production with true end to end automation. The new KrosFlo RS 10 takes all of the components, controls, and capabilities of our highly compliant, commercial manufacturing large-scale TFF systems and brings it down to bench scale.
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Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers superior cell retention. High impact upstream applications include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification.
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Game-changing TFDF® (Tangential Flow Depth Filtration) technology that simplify and intensify upstream viral vector bioprocessing, ideal for AAV, lentivirus, oncolytic, retrovirus, adenovirus, exosomes, and cells on microcarriers.
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State-of-the-art flexible and rigid single-use bags engineered specifically for bioprocessing applications. Optimize handling and transfer of high-value liquids with our range of bottles, carboys, 2D bags, and 3D bags.
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Designed for versatility throughout the bioproduction workflow with patented performance of Metenova® Zero Gravity mixing technology, now optimized for single-use applications. This cutting edge system offers unmatched performance, ease of use, and scalability for both Upstream and Downstream bioprocessing professionals seeking cost-effective, efficent, and easy-to-deploy solutions.
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Engineered for biotech and biopharma, discover a single-use mixer that uses advanced technology to deliver scalable, sterile, and efficient mixing for critical cleanroom applications.
-
Learn about innovative cell retention technology that supports continuous bioprocessing through perfusion cell culture, allowing for longer run times, higher product yields, and reduced costs.
-
Boost product recovery and streamline operations with a single-use TFF system that combines automation and advanced hardware for higher yields, faster turnaround, and reduced manual steps.
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Discover how innovative solutions can reduce production time, cut costs, and improve yields to ensure exceptional product quality at every stage of biologic drug development.
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Learn about a system that enables simple, fast, cost-effective, and scalable upstream intensification development. It delivers precise flow rates, even at high cell densities and viscosities.
FEATURED PRODUCTS
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Designed for versatility throughout the bioproduction workflow with patented performance of Metenova® Zero Gravity mixing technology, now optimized for single-use applications. This cutting edge system offers unmatched performance, ease of use, and scalability for both Upstream and Downstream bioprocessing professionals seeking cost-effective, efficent, and easy-to-deploy solutions.
-
State-of-the-art flexible and rigid single-use bags engineered specifically for bioprocessing applications. Optimize handling and transfer of high-value liquids with our range of bottles, carboys, 2D bags, and 3D bags.
-
Game-changing TFDF® (Tangential Flow Depth Filtration) technology that simplify and intensify upstream viral vector bioprocessing, ideal for AAV, lentivirus, oncolytic, retrovirus, adenovirus, exosomes, and cells on microcarriers.
-
Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers superior cell retention. High impact upstream applications include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification.
-
Meet the first bench scale TFF system built specifically for cGMP production with true end to end automation. The new KrosFlo RS 10 takes all of the components, controls, and capabilities of our highly compliant, commercial manufacturing large-scale TFF systems and brings it down to bench scale.

