Investigation Of XCell® ATF Perfusion Technology For Virus Manufacturing Process Intensification At MSD Animal Health

The market demand for viral vaccines is increasing, so manufacturers are continuously seeking ways to improve their process efficiency. Often, capacity is increased by adjusting batch sizes or increasing the frequency of batches. However, eventually, manufacturers run out of space within their facilities to increase capacity. Perfusion technology allows cell cultures to be maintained at higher densities while maintaining nutrient supply and waste metabolite removal. This allows for higher cell densities in existing process equipment while maintaining the high quality of the biological production system.

This white paper explores the use of XCell^® ATF Perfusion Technology in the manufacturing of cell culture and viral antigen for animal vaccines. The XCell ATF Perfusion System helped maintain high cell viability and growth, allowed for closed system operation, and supported high-density cell and virus manufacturing.

To learn more about the benefits of using XCell ATF Perfusion Technology for animal vaccine manufacturing, access the full white paper here.