Newsletter | April 16, 2024

04.16.24 -- Nanoscope Therapeutics Tackling Vision Loss With Ocular Gene Therapy

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FROM THE EDITOR

Nanoscope Therapeutics Tackling Vision Loss With Ocular Gene Therapy

Sulagna Bhattacharya, MBA, Co-founder and CEO; Samuel Barone, MD, Chief Medical officer; and Samar Mohanty, Ph.D., Co-Founder and President of Nanoscope Therapeutics answer questions about the safety and efficacy data and next steps for the company's RESTORE trial.

INDUSTRY INSIGHTS

Exploring Osmolality As A CQA Within RNA Therapeutics

Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

3 Steps To Digital-First Quality

Explore a proven three-step process designed to help companies quickly transition to a modern quality control system and accelerate their all-digital quality management initiatives.

A Right-First-Time Approach To Viral Vector Manufacturing

Review an approach that's making gene therapies accessible to more patients by overcoming current issues limiting the available capacity for viral-vector manufacturing.

Robust Harvest Clarification For Adeno-Associated Viral Vectors

This article demonstrates that depth filters clarify AAV vectors, helping to overcome the unique separation challenges presented by these important vectors for gene therapy.

Unraveling The Complexities Of Cancer Through Human-Relevant Models

The current paradigm in preclinical testing for cancer therapeutics is proving inadequate. Learn about Organ-on-a-Chip technology and how it is improving 3D cancer modeling.

High-Titer rAAV Production In Bioreactors Using Producer Cell Lines

Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes.

Efficient FBS Removal And Cell Concentration In Vero Cell Cultures

See how an instrument that's showing potential for optimized Vero cell culture processes is able to achieve consistent concentration, maintain high cell viability, and keep an 89.6% reduction in FBS levels.

Accelerate The Development Of CRISPR-Edited Cell Line Models

Evaluate a peer analysis of how a single cell dispenser helped their research team streamline the development process of single-cell clones for the cell lines they are working with.

Genderless Sterile Connectors Offer Flexibility And Faster Changeovers

Genderless sterile connectors — with their ability to interconnect with each other without male/female limitations — can enhance the flexibility of single-use systems in a range of bioprocessing applications.

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