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| DNA and RNA must be removed in the manufacturing process because they can cause unwanted immune reactions in patients and limit the efficiency of downstream purification steps. However, high salt conditions inhibit activity of conventional endonucleases. Benzonase® Salt Tolerant endonuclease is a GMP grade solution for nucleic acid removal even at high salt concentrations. It is devoid of glycosylation and post-translational modifications, and is compatible with common detergents for cell lysis, including the Deviron® portfolio. |
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By Erin Harris, editor-in-chief, Cell & Gene | Sulagna Bhattacharya, MBA, Co-founder and CEO; Samuel Barone, MD, Chief Medical officer; and Samar Mohanty, Ph.D., Co-Founder and President of Nanoscope Therapeutics answer questions about the safety and efficacy data and next steps for the company's RESTORE trial. |
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| Exploring Osmolality As A CQA Within RNA Therapeutics | Poster | By Kendal Studd, Advanced Instruments, Inc. | Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques. |
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| 3 Steps To Digital-First Quality | e-book | Honeywell Process Solutions | Explore a proven three-step process designed to help companies quickly transition to a modern quality control system and accelerate their all-digital quality management initiatives. |
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| Robust Harvest Clarification For Adeno-Associated Viral Vectors | Article | By Thomas Parker, Youness Cherradi, Ph.D., Claire Scanlan, and Elina Gousseinov, MilliporeSigma | This article demonstrates that depth filters clarify AAV vectors, helping to overcome the unique separation challenges presented by these important vectors for gene therapy. |
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| High-Titer rAAV Production In Bioreactors Using Producer Cell Lines | Poster | By J. Coronel, A. Al-Dali, A. Patil, K. Srinivasan, T. Braß, K. Hein, and S. Wissing, Cytiva | Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes. |
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| Join 2500+ global delegates from academia, regulatory and industry at the premier cell and gene therapy translation event of the year, ISCT 2024 Vancouver. Foster global collaborations, discover the latest scientific breakthroughs in gene-edited EVs, iPSC, NK cells, and point-of-care manufacturing and participate in 50+ roundtables on topics including exosomes, CAR-Ts, AI, and regulatory harmonization. Register Now |
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