INSIGHTS ON CELL & GENE THERAPY DISCOVERY

• Cell And Gene Therapies: Opportunities For Innovation

  As researchers and developers work to transform the way diseases are treated, learn why cell and gene therapies will continue to be the center of innovation in the coming years.

• Process Optimization For Assays: A Framework For Controlling Variability And Optimizing Assay Performance

  Read how a process optimization approach to assay development can improve assay performance, thereby reducing variability, improving productivity, and strengthening the robustness of the data that important decisions rely on.

• Orthogonal Fragmentation Mechanism Enables New Levels Of Metabolite Characterization

  Fragmentation is required to provide structural information about metabolites during drug discovery. Here, two orthogonal fragmentation techniques are compared to determine the in vitro metabolism of the drug darunavir.

• Tunable Electron Activated Dissociation (EAD) MS/MS To Preserve Particularly Labile Post-Translational Modifications

  Post-translational modifications (PTMs) are important players in a diverse group of functions that include protein conformation and signaling. This application note studies the site-localization of malonylated peptides using the SCIEX ZenoTOF 7600 system.

• High-Throughput Characterization Of RNA

  Here we demonstrate how a multi-capillary capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.

• Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices?

  We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.

• How Takeda Streamlines Assay Transfer And Troubleshooting With The Multichannel Verification System

  When one of Takeda’s quality control facilities wanted to improve assay success rates by reducing liquid handling variability, they turned to Artel to help their assay process.

• Improving Automated Liquid Handling Performance For Serum Based Assays

  In this study we show the similarities of serum mimic solution compared to various commercially available sera and the importance of choosing the appropriate liquid classes.

• Uniformity Of Gene Expression Measurements On The QuantStudio 7 Pro Real-Time PCR System

  We demonstrate a system that combines all of the qPCR features scientists want in a single high-performance instrument so that you can optimize your research productivity.

• Pharma R&D Annual Review 2022 Supplement: New Active Substances Launched During 2021

  See the industry’s NAS success stories: new chemical or biological entities where the active ingredient had received no prior approval for human use.