INSIGHTS ON CELL & GENE THERAPY DISCOVERY
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Advanced In Vitro Duodenal Model For Toxicity Assessment
Here, we review how an advanced in vitro model closely aligned with the human duodenum was utilized to evaluate the toxicity of indomethacin, a known gastrointestinal toxicant.
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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The Application Of The Species-Specific Liver-Chip In Predicting Hepatoxicity
An evaluation of 150 drug candidates causing adverse events in humans revealed testing in rats and dogs predicted only 71% of toxicities in humans. Discover a solution to this translational challenge.
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The Importance Of Specificity In Preclinical Drug Development Models
It is crucial for models to not only detect toxic drugs but also to avoid erroneously identifying safe drugs as harmful. Learn about the importance of specificity in the early stages of drug development.
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Unraveling The Complexities Of Cancer Through Human-Relevant Models
The current paradigm in preclinical testing for cancer therapeutics is proving inadequate. Learn about Organ-on-a-Chip technology and how it is improving 3D cancer modeling.
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CRISPR Clinical Trials To Follow In 2024 And Beyond
CRISPR therapies are being developed for genetic disorders, cancer, and infectious diseases. Explore which CRISPR clinical trials are worth keeping an eye on this year
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Using Affinity Chromatography For The Purification Of Lentiviral Particles
This new new affinity chromatography resin offers an efficient and scalable purification method for lentiviral particles in combination with gentle elution conditions to retain viral infectivity.
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A More Human-Relevant Model To Advance AAV-Based Gene Therapies
Learn about a liver-chip that offers a more human-relevant way of testing viral vectors compared to conventional models and why it is a promising tool for advancing AAV gene therapy.
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Advancing Precision Medicine With Patient-On-A-Chip
Emulate and Cedars-Sinai Medical Center have partnered to develop a Patient-on-a-Chip program that combines their stem cell expertise and Organs-on-Chips technology to advance precision medicine.
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Protecting Human Health With Organ-On-A-Chip Technology
Explore compelling evidence that suggests Organ-on-a-Chip technology offers a far more reliable means of predicting drug toxicity than traditional animal models.