INSIGHTS ON CELL & GENE THERAPY DISCOVERY

• Stable Cell Lines For Lentivirus And Gammaretrovirus Production

  Explore the advantages and disadvantages of transient transfection and the reasons many viral vector (VV) developers are moving towards using stable producer cell lines for lentiviral vector (LV) development.

• What’s Next For Advanced Therapies?

  The advanced therapies sector is growing exponentially. This paper discusses the future of advanced therapies from the perspective of industry leaders.

• Current Trends In Gene Therapy According To Citeline Data (Jan 2017–Aug 2022)

  The success of gene therapies to date continues to spark an exciting second wave that is laying the foundation for next-generation technologies across several therapeutic areas—oncology, cardiovascular, muscular disorders, neurological conditions, and others.

• When Considering Adipose Mesenchymal Stromal/Stem Cells

  Regardless of your favorite nomenclature for adipose tissue-derived hMSCs (hAD-MSCs, MSC(AT),AT-MSCs), there really is more beneath their story than meets the eye.

• Precise Measurement Of Transduction Efficiency At Single-Cell Resolution For Cell And Gene Therapy Development

  Explore how this platform demonstrates that single-cell DNA sequencing identifies transduced versus non-transduced cells with accuracy and precision while reducing sample processing time.

• Leveraging Single-Cell DNA Sequencing For In-Depth Characterization Of Cell And Gene Therapies

  In this poster, we demonstrate that single-cell DNA sequencing on this platform provides sensitive and nuanced quantification of genetic edits made to up to 10,000 individual cells with a simple workflow.

• Challenges And Innovation In Gene Therapy Manufacturing

  The road to final approval for a biotherapeutic is long and filled with obstacles, from manufacturing and scale-up to regulatory adherence and business practices.

• A Novel Approach To Type 1 Diabetes Treatment

  With the combination of a viral vector platform and a fixed bed bioreactor platform, a lab is working on a curative gene therapy that could address and possibly reverse T1D's underlying mechanisms.

• When Every Sample Is A Life Trusted To Our Care: How CRL Automated Assay And Scale Throughput

  Discover how our technology played a critical role in CRL’s exceptionally fast development and scale-up of a saliva-based SARS-CoV-2 assay to meet the unprecedented testing need.

• Characterization Of An Antibody-Drug-Conjugate (ADC) Using Electron Activated Dissociation (EAD)

  Explore the characterization of lysine-linked drugs in an ADC sample using a bottom-up approach to determine the position of conjugation.