02.17.26 -- Leveraging Conventional Therapeutics Skills For Cell And Gene Therapy

Discover how low-shear centrifugation improves lentiviral vector recovery by replacing traditional depth filtration with closed, automated systems that preserve yield and reduce waste and production costs.

Learn how a low-code approach to MES systems delivers speed, flexibility, and compliance, empowering manufacturers to overcome bottlenecks and embrace digital transformation with confidence.

Unlock superior non-viral CAR T manufacturing outcomes by combining gentle microbubble T cell isolation with advanced electroporation. See how this approach boosts cell viability and transfection efficiency.

Ensure personnel safety during hazardous material handling by mastering airflow dynamics and containment screens. Achieve low exposure levels through these advanced HEPA filtration methods.

Scalable rAAV production is possible with a transient cell line and optimized bioreactor setup, delivering high titers and reduced impurities, now validated at 200 L scale for commercial readiness.

Scaling up stem cell production presents unique hurdles. Uncover crucial considerations, from initial development to large-scale manufacturing, to ensure cell quality and successful outcomes.

For groundbreaking genetic treatments, stringent quality control is non-negotiable. This exploration delves into defining essential attributes and the analytical tools that safeguard their consistent production.

Explore an assay kit that simplifies handling with a methylcellulose-free medium and clear flow cytometric readout, which enhances automation and high-throughput sample acquisition for versatile research.

Increase manufacturing flexibility with modular filling and closing systems. See the benefits of automated processing of vials, syringes, and cartridges designed for compact pharmaceutical manufacturing.

Examine how engineered exosomes, displaying tumor-homing peptides, offer a promising tool for targeted cytotoxic drug delivery, produced efficiently with a bioreactor for critical research.

Learn more about manufacturing principles of LV vectors as well as testing requirement regulatory considerations with a particular focus on the replication of competent virus assay and infectious titer assay.