Redefining Lentiviral Clarification: A New Path To Higher Yields And Lower Costs

Traditional lentiviral vector clarification often sacrifices up to twenty percent of harvested product to the inherent inefficiencies of depth filtration. This loss, combined with the logistical weight of staging, flushing, and disposing of bulky filter trains, creates a significant bottleneck for scaling gene therapies. Transitioning to low-shear centrifugation offers a cleaner alternative, protecting fragile viral particles while maintaining recoveries above ninety percent.

By adopting a closed, automated approach to harvest, manufacturers can significantly reduce cleanroom footprints and buffer requirements. This shift not only preserves weeks of upstream effort but also streamlines the path from small-scale development to commercial production. To learn more about the impact of optimized clarification on manufacturing timelines, read the complete article.