Newsletter | August 19, 2025

08.19.25 -- Inside Arbor Biotech's In Vivo Gene Therapy Approach

SPONSOR

New Whitepaper: Insights into MSC-Based Therapies

Discover key advancements in MSC-based therapies with insights from Corning's Field Application Scientists. Explore methods for MSC isolation, production considerations, media options, cell expansion technologies, and cGMP manufacturing. Gain valuable learnings from collaborations with academic researchers, biotech, and pharmaceutical companies, featuring real-world case studies. Whether you're scaling for clinical applications or advancing research, this whitepaper provides actionable strategies to optimize MSC production and push the boundaries of therapeutic development.

FOCUS ON MANUFACTURING

Inside Arbor Biotech's In Vivo Gene Therapy Approach

Following recent news about first-in-human testing, two executives discuss the science and manufacturing strategy for the company's lead candidate, ABO-101.

How Tunable Cell Processing Solutions Ensure Separation Efficiency

Single-use tubular bowl centrifuges are standing out to cell therapy developers for their ability enable the optimal balance between high separation efficiency, high productivity, and low shear.

EVs Answer To The CAR-Tease: Targeted Exosomes

Researchers are exploring extracellular vesicles to deliver CARs, potentially offering safer, more accessible, and effective treatments compared to current CAR-T cell therapies.

CD8+ Single Positive T Cell Differentiation From HiPSC

Learn about a feeder-free method to differentiate CD8+ single positive T cells from human induced pluripotent stem cells, which offers promising advancements for scalable and efficient cell therapies.

Optimizing CAR T-Cell Development Starts With Your Cell Incubator

Explore how precise cell culture conditions are critical to advancing CAR T-cell therapies, which empowers researchers to develop more effective cancer treatments and accelerate breakthroughs.

Nanomedicine Modalities Find Path To Clinic Through Analytics

Lipid nanoparticles have revolutionized drug delivery, ushering in a new era of nanomedicine. Discover how advanced analytical tools are accelerating next-generation LNP therapeutics.

Flow Cytometric Assays For CAR-T Cell Manufacturing

Join Dr. Stephen Wilmes, PhD, as he explores the critical role of flow cytometry in analyzing CAR-T cell products to focus on identity, purity, potency, and new technologies enhancing assay sensitivity.

Large Scale Purification Of Oligonucleotides With IEX

As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

Ways To Enhance Access To Cell Therapies

Cell therapies are revolutionizing cancer care, but their complex manufacturing and high costs bar access for many patients. Automation is emerging as an efficacious solution to reach patients in need.

TFF For Laboratory And Process Development Applications

Learn about the basic principles that govern tangential flow filtration (TFF) along with the use of TFF capsules and cassettes in laboratory and process development applications.

Mixing Modes In IRO For CAR-T Manufacturing

Unlock superior cell and gene therapy manufacturing with IRO's novel bioreactor geometry and flexible operating parameters for optimal control.

Next-Generation Cell Therapy: Eliminating Thermal Shock In Electroporation

Conventional electroporation methods struggle with damaging heat buildup. Discover how innovative flow technology leverages physics to protect cells and enable large-scale therapeutic production.

SPONSOR

Webinar: From Imaging to Insight: Cell Cycle Mapping in Tumors with Advanced Multiplexing & Spatial Profiling

This Danaher webinar explores how multiplexed imaging and spatial profiling drive insights in drug discovery and translational research. Dr. Wayne Stallaert shares how his team maps cell cycle dynamics to uncover resistance in cancer. Learn how Abcam antibodies and Leica’s Cell DIVE platform enable spatial profiling to support biomarker discovery in PDAC and breast cancer. Learn more here.

MANUFACTURING SOLUTIONS

Downstream Process Development Support And Services - Bio-Rad Laboratories, Inc.

Cell Culture, Fermentation, And Commercial Manufacturing - Eppendorf SE

Prefilled Syringe Plungers - West Pharmaceutical Services, Inc.

Breaking Productivity Barriers In Upstream Bioprocessing - Repligen

Comprehensive Solution For Autologous Cell Therapy Manufacturing - Cytiva

Medium For High AAV Titers Across Multiple HEK293 Cell Lines - MilliporeSigma

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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