Translational Research

  1. Ori Spotlight: Building Early-Phase CGT Infrastructure For Translational Success 8/27/2025

    Tighter integration between research, process development, and manufacturing is key to accelerating the translation of cell therapies from the lab to the clinic. Learn how a leading academic center is doing it.

  2. Early-Phase Whole-Body PK 4/21/2025

    Accelerate your path to the clinic with Aliri’s cost-effective, label-free whole-body PK service — designed to deliver deeper insights, faster decisions, and better outcomes for your drug candidates.

  3. A Derivatization-Free LCMS Assay For 4β-hydroxycholesterol 1/23/2025

    Learn about a novel LCMS assay for 4β-hydroxycholesterol, a key biomarker for CYP3A activity. This derivatization-free method offers a faster and more efficient approach for clinical studies.

  4. Antisense Oligonucleotide Extraction Optimization Reveals Differences 2/17/2025

    Our findings provide critical insights into refining ASO extraction protocols, which can enhance the accuracy of downstream analyses and support further research into ASO-based therapeutics.

  5. Why iPSC Is Research Thriving 5/23/2025

    In this first segment of Cell & Gene Live, Unlocking the Potential of iPSC Therapies in Regenerative Medicine, Julie Allickson, Ph.D., Chief Technology Officer at Mayo Clinic's Center for Regenerative Biotherapeutics and Erin Kimbrel, Ph.D., Head of Cell & Gene Therapy Research at Astellas highlight the transformative potential of regenerative medicine and iPSC-based therapies. They emphasize the versatility and scalability of pluripotent stem cells, particularly for allogeneic applications that could eliminate the need for immunosuppression. These advances hold promise for treating complex diseases like diabetes, multiple sclerosis, and cardiac conditions, with the goal of making therapies more accessible and impactful on a global scale.

  6. Why Material Definitions Matter In Cell And Gene Therapy 4/1/2026

    In this first segment of Cell & Gene Live, Anthony Blaszczyk, Ph.D., Senior Scientist at the U.S. Pharmacopeia, and Basak Clements, Ph.D., Founder and Senior Advisor at biomatria, were joined by Cell & Gene Chief Editor Erin Harris to discuss why cell and gene therapy, clearly defining raw, starting, and ancillary materials, and using those terms consistently, is critical.

  7. Can You Run Crude Samples Using An SPR Instrument? 2/17/2022

    We explore a common misconception and provide examples of complex material being used in an SPR system.

  8. Achieving Stability For mRNA 1/29/2024

    Expert panelists for this Cell & Gene live event share some of things researchers are exploring to keep mRNA more stable.

  9. LC/MS Method For Measurement In Human Plasma 2/17/2025

    According to the researchers, this plasma-based measurement has the potential to serve as a critical pharmacodynamic biomarker, facilitating the assessment of novel therapeutic approaches.

  10. Real-Time Monitoring And Automated Sampling For Enhanced Efficiency 3/17/2025

    Integrating real-time, in-line monitoring with automated sampling in bioprocessing enhances efficiency and precision. Discover how advanced spectroscopy provides non-destructive insights to optimize cell growth and productivity.