Cell and Gene Manufacturing and Logistics

  1. Rapid Analytics And Next Generation Sequencing 10/28/2025

    In vivo RNA optimization enhances liver gene editing by improving delivery, precision, and safety, which accelerates therapeutic development through advanced sequencing and integrated manufacturing technologies.

  2. Optimize DNA Clearance In High-Salt, GMP-Grade Purification Processes 10/28/2025

    Explore how salt-active endonucleases overcome DNA clearance challenges in viral vector purification by digesting down to 3–5 nucleotides and performing reliably in high-salt conditions.

  3. The Case For Optimized And Excipient GMP Cell Culture Solutions 10/27/2025

    Learn how optimized, customizable formulations and Excipient GMP manufacturing streamline development, ensuring quality and consistency for a de-risked path to the clinic.

  4. How Early Manufacturing Decisions Shape Long-Term Success 10/27/2025

    Early manufacturing choices in cell and gene therapy shape long-term clinical and commercial success, so leaders from Allogene and Verismo emphasized that both autologous and allogeneic developers should prioritize process simplicity, risk-based decision-making, and adaptable manufacturing as therapies move from concept to clinic.

  5. How Blast Freezing Affects The Quality Of Bottled Drug Substance: Test Results And Insights 10/27/2025

    Uneven ice formation during bottle freezing creates a "Volcano Effect," pushing solutes into highly concentrated zones. This test-based study explains this risk to drug substance quality.

  6. Freezing Bottles – 5 Critical Considerations 10/27/2025

    Learn five critical considerations for freezing bottles, including uniform rate control, container integrity, and selecting the right freezing technology to maintain product stability and process efficiency.

  7. Supporting Complex Manufacturing For Liquid And Lyophilized Drug Products 10/24/2025

    Aseptic fill and finish operations gain efficiency and precision with modular isolator technology, inline weight checks, and lyophilization, which are ideal for mRNA-LNPs and other sensitive modalities.

  8. Cell Culture Media Filtration: Evaluating Cell Culture Performance 10/23/2025

    Cell culture performance remained consistent across PES and PVDF filters, even under worst-case filtration conditions. Discover a practical framework for evaluating membrane impact on CHO cell growth.

  9. Enhancing Non-Viral CAR T Manufacturing With Electroporation And Microbubble T Cell Isolation 10/22/2025

    Unlock superior non-viral CAR T manufacturing outcomes by combining gentle microbubble T cell isolation with advanced electroporation. See how this approach boosts cell viability and transfection efficiency.

  10. Advancing Allogeneic Cell Therapy for SCI and Blindness with Lineage's Brian Culley 10/22/2025

    On episode 114 of Cell & Gene: The Podcast, Host Erin Harris talks to Brian Culley, CEO of Lineage Cell Therapeutics, about advancing cell therapy beyond oncology and into transformative treatments for conditions such as spinal cord injury and blindness.