MilliporeSigma Products

  1. Sf-RVN® Platform For Production Of Recombinant Proteins And Clinical Stage AAV 3/29/2022

    The baculovirus-insect cell system is widely used for production of recombinant proteins and clinical stage AAV due to its flexibility, speed, simplicity, and productivity.

    The Sf-RVN® Insect Cell Line is a rhabdovirus-negative Sf9 cell line that can be grown in both adherent and suspension culture. Sf-RVN® Insect Cell Line has been adapted for growth in a chemically defined medium to be used for the production of recombinant proteins, adeno-associated viruses (AAV) and viral-like particles (VLP). The EX-CELL® CD Insect Cell Medium, recommended for use, is optimized to get excellent growth and productivity of the Sf-RVN® Insect Cell Line. Combined, these two products form the Sf-RVN® Platform to help improve the safety profile of your gene therapy.

  2. VirusExpress® 293 AAV Production Platform 9/3/2021

    You’re developing lifesaving gene therapies and need to manufacture AAV vector as quickly as possible. But scale-up and regulatory hurdles make the path to the clinic slow and labor intensive. We’re here to help.

    The VirusExpress® 293 AAV Production Platform offers a transfection-based solution using a suspension-adapted cell line, which is GMP banked and characterized, chemically defined medium, and a process with proven performance at clinically relevant scale.

  3. CellPrime® rAlbumin 8/25/2021

    CellPrime® rAlbumin is expressed in Pichia pastoris from a gene construct that encodes a non-glycosylated human albumin.

  4. Stemline® Stem Cell Culture Media 6/15/2021

    In recent years, the development of media used to expand and mature adult stem cells has greatly increased the success rate of adult stem cell therapy and the breadth of potential stem cell-based therapies. To obtain enough cells, ex vivo expansion has been utilized to ensure successful engraftment and economize the manufacture of both allogeneic and autologous therapies.

  5. Viral & Gene Therapy Manufacturing CDMO Services 6/15/2021

    You’ve developed your viral vector gene therapy and now it’s time to embark on the voyage to manufacturing. But gene therapy production is uncharted territory, and you need someone to help navigate through the process. We can help.

  6. VirusExpress® Lentivirus Production Platform 3/4/2021

    You’re developing lifesaving gene-modified cell therapies and need to manufacture lentiviral vector as quickly as possible. But scale-up and regulatory hurdles make the path to the clinic slow and labor intensive.

    We're here to help.

  7. Chromatography Membrane For Single-Use Per Batch Biomolecule Purification 9/21/2020

    For single-use per batch biomolecule purification

    A high capacity, high throughput strong anion exchange chromatography membrane designed for single-use per batch biomolecule purification. The unique Natrix® Q membrane contains a high density of quaternary amine ligands that are directly polymerized within the porous membrane scaffold.

  8. Benzonase® endonuclease Safety Plus Emprove® Expert 1/15/2020

    Benzonase® endonuclease — the smart solution for DNA removal in biopharmaceutical production.

  9. NovaSeptum® GO Sterile Sampling Systems 10/17/2019

    From your bioreactor to final sterile filtration, the new NovaSeptum® GO sampling system lets you sample processes the way you want. Flexible formats and volumes adapt to your process for robust, reliable monitoring and quality assurance.

  10. Integrated Mixing And Filtration Solution For Economic And Processing Flexibility 10/17/2016

    MilliporeSigma’s Mobius® single-use mixing solutions deliver advanced technology for mixing pharmaceutical ingredients from intermediate to final drug products and for the preparation of process solutions, such as buffers and media. Unlike traditional stainless-steel mixers, single-use mixers reduce downtime due to CIP, SIP, cleaning validation, and process engineering. Mobius® single-use mixing solutions also offer operational flexibility as they can be up and running in less than five minutes. They are capable of mixing speeds up to 1000 RPMs meeting the broadest range of mixing production requirements. Mobius® flexibility offers you a choice of just the right filter, connector, tubing options for your specific application and environment, including sterile interfaces, from fermentation to final fill. Sizes range from 10 L to 3000 L.