MilliporeSigma Articles

  1. Single-Use Multi-Layer Film Delivers Comparable Cell Growth Performance To Glass 5/12/2023

    Explore the findings of studies analyzing the performance of upstream bioprocessing with Ultimus® film, a single-use, multi-layer film with a fluid contact layer free of Irgafos® 168.

  2. How Data Analytics Accelerates Transition To Bioprocessing 4.0 4/7/2023

    Following successful Industry 4.0 implementation in the automotive, communications, aerospace, and other industries, the biopharma industry is now joining the digital revolution.

  3. Orthogonal Methods To Understand And Define CQAs Of AAV Therapies 2/24/2023

    An essential part of AAV vector production is the characterization of potential CQAs. Learn about novel, robust, and orthogonal methods that can be used to assess identity, purity, and residuals.

  4. Biosafety Testing And Quality Control Requirements For Lentiviral Vectors 9/26/2022

    Learn more about manufacturing principles of LV vectors as well as testing requirement regulatory considerations with a particular focus on the replication competent virus assay and infectious titer assay.

  5. Using Next Generation Sequencing Methods For Virus Vector Identity Testing 9/7/2022

    Sequencing techniques play a crucial role in establishing the quality attributes of a variety of therapeutic products. Learn what advantages NGS offers for obtaining accurate sequences.

  6. Navigating The Regulatory Maze: Fundamentals For Drug Development 7/15/2022

    Learn about key regulatory concepts and ways to accelerate and reduce risk throughout the drug development journey. 

  7. Remote Access And Monitoring Of Bioprocess Unit Operations 5/26/2022

    Digital transformation projects require a scalable connectivity solution for the manufacturing floor that is easily and rapidly deployed. Explore elements that enable connectivity among equipment.

  8. Utilizing Multiple Tech Providers In Gene Therapy Manufacturing 5/19/2022

    With a diverse landscape of potential partners, it is important to know what qualities to look for in a technology provider and how to traverse the challenges inherent in managing multiple relationships.

  9. Development Of A Novel Sf9 Rhabdovirus-Negative Cell Line (Sf-RVN®) And Companion Chemically Defined Medium 3/15/2022

    This whitepaper describes the development of a novel Sf-RVN® cell line, with companion chemically defined medium, the EXCELL® CD Insect Cell Medium which can be combined and offer a Sf-Rhabdovirus free alternative for the BICS production of biologics.

  10. A Multifaceted Strategy For Viral Safety In AAV Processes 3/10/2022

    Assurance of viral clearance can be difficult, however, during production of vectors such as adeno-associated viruses (AAV) used for the purpose of gene delivery. The need to define and deploy an appropriate and robust viral clearance strategy can be particularly challenging without an overarching strategy in place.