C&G Editor in Chief, Erin Harris
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A Growing Emphasis On Gene Silencing
11/17/2022
I chatted with Tom Payne, Laverock Therepeutics' Chief Operating Officer, about the company’s mission to utilize its Gene Editing induced Gene Silencing (GEiGS) technology, and its associated computational platform, to engineer induced pluripotent stem cells (iPSC)-derived cell therapies with improved efficacy, safety, and accessibility.
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The Promising Future Of Oligonucleotides
10/31/2022
Episode 35 of Cell & Gene: The Podcast features Dr. Michelle Mellion, PepGen’s SVP Head of Clinical Development at Cambridge, MA-based biotech PepGen. In it, Dr. Mellion talks all about the company’s oligonucleotide therapeutics that were developed to treat severe neuromuscular and neurologic diseases, such as Duchenne Muscular Dystrophy (DMD).
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Life Science Leader’s Annual Industry Outlook Issue: What Didn’t Make It To Print
10/25/2022
Cell & Gene’s sister publication and fellow Life Science Connect resource, Life Science Leader magazine, is the essential business journal for life science executives who work for everything from emerging biotechs to Big Pharmas, aka you.
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Meeting On The Mesa 2022: Big Pictures & Takeaways
10/18/2022
Alliance for Regenerative Medicine (ARM)’s Meeting on the Mesa (MOTM) 2022 was held October 11-13, 2022 in Carlsbad, CA. The meeting was packed with good information, and I wanted to share with you just a few of the most important soundbites I gleaned from the event. So, whether you attended the event in person, or you want to know what you may have missed, here are some of the highlights from MOTM 2022.
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CGT 2023: A Look Ahead
10/7/2022
Once a month, my Life Science Connect editorial colleagues and I meet to discuss the most pressing topics in our respective coverage areas to learn from each other and to address any overlaps (hint: there are always many overlapping issues). Fresh off our most recent meeting, I thought I’d share with you what we covered and what are just some of the topics and trends Cell & Gene will continue to cover into next year.
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Breakdown Of Cell & Gene Live: Advancements In Targeted mRNA Delivery
9/21/2022
During our Cell & Gene Live, Advancements in Targeted mRNA Delivery, Dr. Murat Kalayoglu, CEO of Cartesian Therapeutics, Walter Strapps, Ph.D., Co-Founder and CEO of Carver Biosciences, and I spent the hour talking about the delivery of mRNA-based therapeutics. Our expert panelists discussed the specific challenges and opportunities in delivering conventional RNA therapeutics clinically, as well as the specific challenges and opportunities in delivering the RNA cell therapies clinically. You can view the full-length presentation here. For your convenience, we’ve broken down the hour into bite-size chunks based on the important topics we discussed throughout the hour.
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Capstan Therapeutics’ Next Steps For In Vivo CAR Therapies
9/19/2022
Capstan Therapeutics is a brand-new biotech company dedicated to developing and delivering precise in vivo cell engineering to patients. With $165 million in financing, Capstan Therapeutics aims to build on the foundational insights of leaders in mRNA and cell therapy from the University of Pennsylvania. Laura Shawver, Ph.D., leads the company as President and CEO, and on the heels of the biotech’s recent news, I caught up with her to learn more about the company’s plans for developing in vivo CAR therapies.
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August 2022 on Cell & Gene: The Podcast
8/31/2022
In case you missed it, we have featured some of the cell and gene therapy sector’s best and brightest luminaries on Cell & Gene: The Podcast to discuss everything from the future of CAR-T therapy to stem cell-derived treatment for Type 1 diabetes to best practices in partnering with a CDMO. Here’s a look back at August’s episodes.
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bluebird bio’s $2.8 Million Zynteglo
8/19/2022
bluebird bio’s gene therapy, which will be branded as Zynteglo, is the third gene therapy overall and the first ex vivo lentiviral-based gene therapy to be approved in the U.S. The potentially one-time gene therapy treats adult and pediatric patients with beta-thalassemia who require regular red blood cell transfusions. Beta-thalassemia is an inherited blood disorder that causes an oxygen shortage in the body and often leads to liver and heart issues.
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Nurix Tx, CBM On Scaling Auto & Allo Therapies
8/11/2022
Cell & Gene Live events cover some of the timeliest topics facing the CGT sector. Our most recent Cell & Gene Live, Scaling Cell Therapies: Auto Vs. Allo, is one such event. This Cell & Gene Live’s focus centered on the need to develop processes that scalable and suitable for a manufacturing environment to scale auto and allo therapies. Michael Blackton, SVP Cell Therapy Manufacturing at Nurix Therapeutics and John Lee, VP Head of Cell Therapy at Center for Breakthrough Medicines shared their expertise from the biopharma and CDMO points of view, respectively.