Newsletter | September 16, 2025

09.16.25 -- Lilly's Exploring A Universal AAV Purification Method

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Webinar: Achieving Flexibility In T Cell Manufacturing - Adaptation Of Standardized Processes

Join Miltenyi Bioindustry’s expert-led webinar to explore how the gold-standard T Cell Transduction (TCT) process on the CliniMACS Prodigy® platform is transforming CAR-T manufacturing. Discover scalable, standardized solutions to accelerate production while preserving potency. Gain insights into G-Rex® integration, process development support, and in-depth analysis of expansion, efficiency, exhaustion, and tumor-killing performance to advance your cell therapy programs. Click here to learn more.

FOCUS ON MANUFACTURING

Lilly's Exploring A Universal AAV Purification Method

Serotype-specific resins don't scale gracefully. One team at Eli Lilly and Company is exploring an alternative that skips affinity resins altogether.

 

Challenges, Methods, And Solutions For Obtaining Optimal Starting Material

For innovative treatments like CAR-T and stem cell transplants, optimal starting material is key. Understanding collection challenges and new solutions helps ensure the best foundation for these therapies.

Point-Of-Care Manufacturing Vs. Decentralized Manufacturing

Which production model is best suited for your cell and gene therapies, Point-of-Care (PoC) or Decentralized Manufacturing? Explore the impact of both approaches.

Upscaling hMSC Production Enhances EV Secretion And Cargo Profile

Explore how the dynamic microenvironment of bioreactors influences the production of extracellular vesicles (EVs), including exosomes, secreted by human mesenchymal stromal cells (hMSCs).

Cell Harvesting: A Strategic Lever In Allogeneic Therapy Production

Current cell harvest techniques in allogeneic manufacturing face limitations, including scalability issues and cell damage. Learn why a shift in approach is vital for high-quality, efficient production at scale.

Exploring MSC-EV Attributes – Analytical Comparison Of Tissue Sources

Uncover how analytical tools assess the impact of production process choices and tissue sources on the quality of cell-derived extracellular vesicles (EVs).

Forget About Isolators: Switching From Manual Vial To Automated Bag Filling

Discover how transitioning from manual vial filling to single-use bag systems can reduce contamination risk, improve accuracy, and enhance GMP compliance in biopharmaceutical manufacturing.

Enabling Research Advances Worldwide

Service expectations for life science customers have evolved. Discover a service solution that offers a comprehensive partnership, which provides proactive maintenance, expert guidance, and continuous support.

How Can I Increase My Viral Titers And Improve The Percentage Of Full AAVs?

Explore various strategies to enhance viral titer and increase the percentage of full AAV capsids, like modifications to transfection reagents, cell lines, media, procedures, and more.

Empowering Biopharma With Single-Use Cryopreservation Solutions

Explore four common applications of cryopreservation and the science behind selecting the appropriate materials to build single-use solutions that enable cryogenic storage for cell and gene applications.

A Transient Cell Line To Produce rAAV With Low-Level hcDNA Encapsidation

Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.

Automating Cell Therapy Manufacturing And Enabling Rapid Tech Transfer

Find out how automating cell therapy manufacturing with a flexible platform can improve biological performance, streamline tech transfer, and support regulatory confidence for scalable, multi-site production.

MANUFACTURING SOLUTIONS

Active, On-Demand Release Of Magnetic Beads From Target Cells - Thermo Fisher Scientific

Partitioned Flow Electroporation - Femtobiomed Inc.

A Revolutionary Single-Use Rocking Bioreactor System - Cytiva

Process Analytical Technology For In-line Bioprocess Analysis - Repligen – PAT

Transforming Drug Delivery - Battelle

EVENTS

Advancing the Future of Cell & Gene Therapy

This 11-12 November, Cell 2025 unites 1,000+ leading experts across the CGT value chain to solve key challenges, from scalable bioprocessing and regulatory hurdles to accelerating development timelines.

 

Gain practical strategies across cell culture, therapy development, and CGT manufacturing, and hear from world-renowned leaders Bobby Gaspar (CEO, Orchard Therapeutics), Christof Von Kalle, (Director & BIH Chair, Research Clinic Luxemburg), and Dame Molly Stevens (University of Oxford). Register Now

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