How Single-Use Cryopreservation Solutions Enable Biopharmaceutical Manufacturing

By Ian Burdick, MBA, Director of Product Management; and Evan Hagen, Business Development Manager, Charter Medical LLC

Cryopreservation is fundamental in biopharmaceutical operations, as it allows researchers and advanced therapy manufacturers to preserve biological specimens for extended periods of time. This technique involves freezing cells and other biological fluids to temperatures between -135°C to -196°C (liquid nitrogen temperatures), effectively halting biological activity while upholding cell integrity and performance. Cryopreservation plays a crucial role today in advancing therapeutic breakthroughs and preserving and delivering cell and gene therapies to hospitals or clinical sites, which subsequently administer them to patients.

As we explore the four common applications of cryopreservation, we will also delve into the science behind selecting appropriate materials for building single-use solutions that enable cryogenic storage for cell and gene applications.