Newsletter | October 1, 2024

10.01.24 -- Leveraging Platform And Process Characterization Data To Accelerate CGT

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Showcasing a Scalable Downstream Platform for Multiple AAV Serotypes

Scientists need a downstream processing platform that can purify a variety of AAV serotypes with consistent recovery and quality to reduce timelines and complexity. In collaboration with iBET, we’ll show how you can select the right solutions to support scalable and high-performing AAV purification. Join us live on October 10th at 11:00 AM EST. Register here.

FOCUS ON MANUFACTURING

Leveraging Platform And Process Characterization Data To Accelerate CGT

This article discusses how cell and gene therapy companies can use prior knowledge and platforms to leverage process characterization to reduce the testing and/or studies required during process validation for drug substance and drug product manufacturing processes.

4 Strategies For Modernizing The Manufacturing Quality Control Lab

Business leaders can enhance QC operations by adopting a holistic view of the quality ecosystem and embracing comprehensive modernization strategies. Explore four principles for greater QC lab agility.

Using Robotics In The ATMP Space

With regulatory requirements and GMP recommendations trending towards less human interaction and more robotic automation, robotics is the way of the future for the ATMP industry.

Enhancing Efficiency And Accuracy In Cell Line Development

Gain insights into the latest advancements in high-resolution multi-plane whole well imaging and the impact of AI-powered image analysis on clonality decisions and optimal clone selection.

Empowering Biopharma With Single-Use Cryopreservation Solutions

Review four common applications of cryopreservation and the science behind selecting the appropriate materials to build single-use solutions that enable cryogenic storage for cell and gene applications.

Accelerating Gene Edited Cell Lines With CRISPR Technology

This study establishes an effective and rapid process for developing a p53 knockout HEK-293 cell pool using CRISPR-based gene editing and antibiotic screening.

hiPSC Aggregate Expansion In Stirred-Tank Bioreactors Using Twin Controller

Learn about a bioreactor-based Human Induced Pluripotent Stem Cell (hiPSC) expansion workflow with the potential to improve cell therapy applications.

Considerations For Developing The Recirculation/Perfusion Process

Discover the recirculation and perfusion processes enabled by single-use, fixed-bed bioreactors, designed to scale up adherent cell culture processes.

Scaling Up The Learning Curve For Large-Scale AAV Manufacturing

The complexity of manufacturing AAV products, coupled with the challenges linked to controlling their costs, underscore the importance of improving the efficiency and scalability of these processes.

Forget Lean Cleanroom Construction, Practice Lean Installation

Lean construction, as a buzzword, gets a lot of play in the cleanroom industry for good reason. It is an idea that got its start with Toyota in the 1950s to maximize efficiency and eliminate waste in production.

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It's no secret that on-going research aims to improve the efficacy and specificity of non-viral approaches for genetic engineering. But the field is rapidly evolving with research aimed at improving transfection efficiency, targeting, and safety profiles of non-viral delivery systems. Join Cell & Gene Live to discuss the most notable approaches and recent breakthroughs as well as promising non-viral vectors used in clinical trials. Attendance is free thanks to the support of MaxCyte.

MANUFACTURING SOLUTIONS

Bioreactors, DOE Expertise To Characterize Processes Prior To PPQ - Culture Biosciences

Large-Scale Manufacturing Of Transduced T Cells - Miltenyi Biotec

Fast-Track Bioanalysis And QC With Scalable Innovative qPCR Tools - Applied Biosystems by Thermo Fisher Scientific, qPCR

ELEVECTA Producer Cell Line For Stable, Inducible AAV Production - Cytiva

Protein Characterization And Metabolomic Analysis - 908 Devices

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Webinar: Innovative Contamination Control in Cell Therapy - Enabling Integrity and Efficiency

Join Thermo Fisher Scientific October 15th as we discuss how automated closed systems and larger bioprocess containers contribute to maintaining the integrity of cell therapy products and explain how rapid analytical assays can offer reliable and accurate contamination detection. Discover how an integrated approach combining these solutions can enhance contamination control, boost process efficiency, and enable the production of high-quality cell therapy products.

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