Newsletter | March 3, 2026

03.03.26 -- Inside Mesoblast's Playbook For Making Allogeneic Cell Therapy Real

FOCUS ON MANUFACTURING

Inside Mesoblast's Playbook For Making Allogeneic Cell Therapy Real

Mesoblast's Silviu Itescu shares how two decades of rigorous science and manufacturing turned allogeneic MSCs into the first FDA-approved cell therapy while building a scalable platform for inflammatory diseases such as GvHD, back pain, and heart failure.

Flexibility For Workflows To Meet Your Process Needs

Evaluate a platform designed for evolving workflows. Explore how flexible platforms manage diverse inputs and parameters to maintain scalability and efficiency as your therapy moves toward the clinic.

Centrifugation Vs. Gravity: Scaling iPSC Media Exchange

Low-shear, closed-system media exchange in iPSC differentiation is vital for scalability. This study compares automated centrifugation to gravity sedimentation, showing equivalent or superior differentiation outcomes.

Optimize, Automate, And Scale Closed-System MSC Expansion

Efficiently scale your MSC therapy manufacturing with closed systems. Learn how a dual-component media kit streamlines automation, reduces variability, and ensures seamless scale-up with minimal optimization.

How CAR Localization Dictates Functional T Cell Performance

Is CAR heterogeneity stalling your progress? New single-cell data indicates spatial organization and cell structure directly influence the potency and behavior of your CAR T cell therapies.

Consider These Risks And Safety Measures For Cytotoxic Compounding

Cytotoxic compounding requires rigorous safety protocols. Protect your operators and products with these techniques and technologies to prevent harmful exposure.

A Platform Standard For Viral Vector Manufacturing And Commercialization

Delve into the details of several platform technologies currently being developed and implemented to support effective, large-scale production of viral vectors that meet set quality attributes.

Maintaining Sterility Through Precise Component Design And Manufacture

Prioritizing high-quality component design and unwavering manufacturing excellence can mitigate risks, ensure long-term container closure integrity, and avoid the costly delays associated with non-compliance.

Reducing Nucleic Acid Impurities In Viral Vector Manufacturing

Achieving high-quality viral vectors demands rigorous control over contaminants. See how enzymatic approaches can significantly reduce nucleic acid impurities in your manufacturing processes.

Efficient Large-Volume Electroporation For Complex T Cell Cargo

Investigate an improved cartridge for the electroporation of complex cargos into large volumes of T cells. Discover how to achieve reliable, robust, and efficient delivery of complex, clinically relevant cargos.

Aseptic Extrusion: Preventing Contamination And Ensuring Product Sterility

Evaluate the critical process considerations and custom engineering required to handle temperature-sensitive and high-viscosity pharmaceutical materials.

MANUFACTURING SOLUTIONS

Tangential Flow Depth Filtration System - Repligen

Cleaning And Disinfectant Bucket System For Manufacturing - Contec, Inc.

Is Your Current AAV Process Holding You Back? - Mirus Bio

Enhance Post-Electroporation Proliferation - Femtobiomed Inc.

Closed Cell Expansion System - Terumo BCT

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