Newsletter | December 10, 2025

12.10.25 -- Advancing Hematology And Cell Therapy Innovation

SPONSOR

Join us for this Cell & Gene Live when Erin Harris, Chief Editor of Cell & Gene welcomes Steve Awad, Principal Director, Supply Chain & Industry X — Life Sciences at Accenture, and Michael Blackton MBA, VP, Manufacturing and Supply at Ocugen to unpack what CGT developers need to know about efficient, compliant dual- or multi-modal manufacturing even when production is outsourced. Registration is free thanks to support from Ecolab Life Sciences.

FOCUS ON TRANSLATIONAL RESEARCH

Advancing Hematology And Cell Therapy Innovation With AstraZeneca's Aliya Omer

On episode 115 of Cell & Gene: The Podcast, Host Erin Harris talks to Aliya Omer who shares valuable insights from her rich experience leading cell therapy development across multiple top companies.

Scalable iPSC Differentiation To Natural Killer Cells With Cytotoxic Potential

Explore an innovative serum-free method to differentiate induced pluripotent stem cells (iPSCs) into natural killer (NK) cells, offering scalable solutions for immunotherapy with enhanced cytotoxic potential.

Evolving Data Review With AI

AI is transforming clinical data review by automating processes and enhancing efficiency. Discover the four stages of evolution that emphasize automation, regulatory alignment, data analysis, and human oversight.

Daring To Learn From Failure: The Future Of Stem Cell Therapy

Stem cell therapy has already revolutionized the field of oncology. But where do we go from here? Dr. Robert S. Negrin addresses three key areas of CAR T-cell therapy on the brink of innovation.

Reflect On 20 Years Of Cancer Research With MIRROR Biospecimens

See how the Matched & Integrated Repository for Rediscovered Oncology Research (MIRROR) for biospecimens can help unlock new discoveries from the tumors that shaped modern precision oncology.

Lost In Translation: Turning Multi-Omic Chaos Into Clinical Clarity

Uncover how this integrated, science-focused approach helps sponsors navigate biological complexity, streamline timelines, and make data driven decisions across a collection of therapy programs.

Determining The Linear Range For Quantitative Western Blot Detection

Assimilate how to determine the linear range for western blot quantification using total protein stains or housekeeping proteins to ensure accurate normalization and avoid saturation effects.

Gamma Delta T Cells Explained: The Next Medical Breakthrough?

Gamma delta (γδ) T cells are emerging as a promising new frontier in cell therapy, offering potential for treating both solid tumors and autoimmune diseases.

Fluorescent Western Blot Detection

Review this step-by-step guidance for fluorescent western blot detection, including membrane prep and antibody handling, to improve signal clarity and consistency across imaging platforms.

Multicolor Flow Cytometry Panel Design

Watch a series of videos on multicolor flow cytometry panel design to gain a comprehensive understanding of the fundamentals of panel design as well as various strategies to streamline panel design.

How To Mitigate Gene Editing Program Risk

A critical challenge for therapeutic programs using CRISPR is managing the risk of off-target effects. Learn how to strengthen the safety of your therapeutic programs with comprehensive assessments.

Unlocking miRNA Biomarkers With NGS And Digital PCR

Delve into how next-generation sequencing and digital PCR enable miRNA biomarker discovery and validation. Learn best practices for sample prep, data analysis, and assay design to advance RNA research.

Gene Therapy Solutions: From Discovery To Commercialization

Learn how advanced technologies and methodologies are driving progress in gene therapy, enabling safer and more effective treatments for rare and complex diseases.

Watch That Car-go! Acceleration Towards MSC-EV Characterization

EV production must align with CMC and regulatory standards before it can reach its full potential. This study compares conditioned medium across scalable platforms to optimize EV manufacturing for the clinic.

AI-Assisted Spatial Proteomics Of Immune Cells In Alzheimer's Brain

AI-driven multiplexed imaging reveals neuroimmune interactions in Alzheimer’s disease, identifying immune cell subtypes near pathological hallmarks like Β-amyloid plaques offering therapeutic insights.

Simplified Workflow Using Automated Instrument Setup And Compensation

Examine the usability and performance capabilities of a system that provides a streamlined flow cytometry workflow, from instrument initialization to data acquisition and analysis.

Efficient Gene Expression Profiling For Biomarker Identification

Solutions for automating qPCR and digital PCR (dPCR) gene expression analysis workflows can help translational research laboratories derive valuable gene expression profiles.

Importance Of Data Reproducibility For Developing Safe Gene Therapies

What are viral-based vectors and why are reproducible quantitation of gene expression important in gene therapy? Explore these questions as well as the interplay among gene therapy vector components.

SPONSOR

Webinar: Advancing targeted in vivo LNPs: Five practical considerations to move from concept to clinic

As targeted in vivo delivery grows more complex, every decision — from payload design to conjugation, analytics, and process strategy — shapes clinical success. In this webinar, Cytiva experts share five practical considerations for advancing targeted in vivo LNP programs, drawing on ARPA-H experience to reveal proven approaches that improve robustness, scalability, and clinical readiness. Click here to learn more.

TRANSLATIONAL RESEARCH SOLUTIONS

Accelerate Discovery In 2D And 3D Cell Imaging - LICORbio

On-Target And Off-Target Assessment Assays - MaxCyte, Inc.

gentleMACS™ Octo Dissociator With Heaters - Miltenyi Biotec

Accelerate Cross Site Collaboration With Simple Assay Transfer - BD Biosciences

TaqMan Assays To Support Your Oncology Research Breakthroughs - Applied Biosystems by Thermo Fisher Scientific, qPCR

Introduction To An End-To-End Clinical Data Science Platform - Revvity Signals Software, Inc.

Ready-To-Use Exosomes That Streamline R&D - RoosterBio

Accelerating Cell Therapy Development Through Collaboration - Thermo Fisher Scientific

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