MilliporeSigma Webinars

  1. Developing Modular Facility Proof-Of-Concept For Multi-Modal Bioprocessing 2/2/2023

    Learn about the innovative solution of designing and constructing manufacturing facilities using predesigned and prefabricated elements.

  2. RNA Interference - From Single Gene Studies To Whole Genome Screens 11/7/2022

    Endoribonuclease-prepared siRNAs (esiRNAs) are able to overcome the limitations of RNAi. Learn about esiRNAs, their advantages over standard siRNAs, and ways this technology is utilized in different research fields.

  3. Identity Testing By NGS As A Means Of Risk Mitigation For Viral Gene Therapies 6/17/2022

    This presentation explores regulatory requirements for identity testing, NGS applications for identity testing as compared to traditional methods, and the impact of not establishing a proper risk-based testing strategy.

     

  4. Application Of Two-Dimensional Chromatography To Improve Productivity Of Analytical Testing Of Cell & Gene Therapy Products 10/13/2021

    Analytical characterization of cell and gene therapy products remains a challenging, costly, and time-consuming task. In this video we present a proof-of-concept work demonstrating application of multidimensional chromatography for characterization of Adenovirus type 5 (Ad5)-based product that not only allowed increased productivity, but also limits the sample volume needed for the analysis.

  5. AAV Gene Therapy: Orthogonal Methods To Understand And Define CQAs 10/13/2021

    As with all biopharmaceuticals, it is important to identify and monitor the critical quality attributes (CQAs) of these products to ensure their safety and efficacy. Our experts present a range of orthogonal methods to understand and define the CQAs of AAV products.

  6. Achieving High Yields In Scalable Xeno-Free Culture Formats With Mesenchymal Stem Cell Medium 7/27/2021

    In this webinar, we will explore the current landscape and future trends of cell culture media for adult mesenchymal stem cells and discuss the options to derive MSC’s from bone marrow in xeno-free conditions from static to microcarrier-based suspension culture platforms. Finally, we will demonstrate the Stemline® XF MSC Media we’ve developed to reduce scalability roadblocks while maintaining robust performance.

  7. Which Ingredient Are You Missing In Your Gene Therapy Success Recipe? 3/25/2021

    In this podcast, Ratish Krishnan, Associate Director for Cell & Gene Therapy talks about the tremendous promise gene therapies have for changing the healthcare paradigm and solutions to some of the biggest challenges in gene therapy manufacturing.

  8. Developing A Scalable Upstream Bioreactor Process For Lentiviral Vector Production In Suspension 3/8/2021

    Gene therapies hold the promise to change lives. As your path to patients accelerates, how can you assure the robust process design, intensification and scalability that meets your evolving manufacturing needs? And what benefits can a templated process bring to your commercial success? Learn the answers to these questions and more in this webinar.

  9. Biosafety In Gene Therapy: Applying The Latest Regulatory Guidance For RCL Testing 2/23/2021

    The use of lentivirus vectors to produce groundbreaking gene therapies is on the rise. Ensuring the biosafety and quality of these vectors is achieved through a multi-tiered testing approach. For lentivirus-based therapies, generation of replication competent particles is a potential risk. While improvements in design and manufacturing have decreased the probability of producing replication competent viruses, regulatory agencies provide guidelines to test for their presence at multiple stages in production.

  10. Addressing The Challenge Of Scalability In Viral Vectors 10/18/2020

    Early viral vector process development for cell and gene therapies is critical to assure a production strategy that supports commercial needs. In this webinar, you will learn the importance of planning for scalability and manufacturability from the earliest stages of process development and how a scalable templated process can reduce time needed to move from product development to commercialization.