Milliporesigma Brochures

  1. Analytical Development And Characterization For AAV

    Our assay packages and phase-appropriate assay development and validation capabilities provide the product and process knowledge you need to develop a QTPP and identify the CQAs for your therapy.

  2. Optimization Of Benzonase® Endonuclease Use In Virus Purification

    The use of Benzonase® endonuclease additionally increases the yield in virus purification, protects the downstream chromatography and filter devices from fouling and reduces feed stream viscosity. In this document we will provide you guidance on how to plan and set up a Design of Experiments (DoE) optimization experiment of Benzonase® endonuclease in your viral gene therapy process.

  3. AAV Biosafety Testing & Characterization Services

    Biosafety testing and characterization for new products are essential as they emerge for clinical study. Both measures will help mitigate safety concerns and confirm product quality before these therapies are administered to patients. Our BioReliance® AAV testing services give you the confidence to get your products to market quickly and safely.

  4. Medium For Producing High AAV Titers In Multiple HEK293 Cell Lines

    Discover a chemically defined medium optimized for AAV production that has been streamlined and cell culture media components incorporated to increase media stability and reduce protein oxidation.

  5. Single-Use Fluid Management

    Mobius® 2D and 3D assemblies, filtration, storage, and transportation solutions are key components for efficient, ergonomic, and scalable single-use fluid management. This interactive brochure is designed to provide you with an overview of our complete single-use fluid management offerings, and a detailed guide to a holistic risk mitigation approach to quality control and assurance to meet your regulatory and compliance needs.

  6. CTDMO Services To Fast-Track The Advancement Of mRNA-Based Drugs

    Discover CTDMO services that establish robust, integrated, and consistent processes across all stages, enabling you to fast-track the advancement of your mRNA-based vaccines and therapeutics.

  7. Viral Clearance Services

    Ensure safety with expert-led viral clearance studies. Our global team delivers regulatory-compliant, scientifically robust solutions to eliminate viral risks and support your product’s success.

  8. VirusExpress® Lentiviral Production Platform

    The VirusExpress® Platform offers a transfection-based solution to lentiviral (LV) production challenges, featuring a suspension adapted cell line, chemically defined medium, and process with proven performance at 50 L scale. The platform can dramatically reduce time in process development and scale-up, either within your own facilities or using our contract manufacturing capabilities to speed your therapy to patients.

  9. A Transfection-Based Solution With Proven Performance At Scale

    The VirusExpress® 293 AAV Production Platform offers a transfection-based solution using a suspension-adapted cell line, which is GMP banked and characterized chemically defined medium, and a process with proven performance at a clinically relevant scale.