Manufacturing

  1. Challenges Of The IVT Reaction In mRNA Production 2/24/2023

    mRNA synthesizes from the plasma template in the in vitro transcription (IVT) step. Learn tips from a principal scientist for optimizing the IVT step of mRNA production and purification.

  2. Simplify Your Downstream Calculations With Bioprocessing Downstream Calculators 4/16/2025

    Simplify complex biopharma downstream processing tasks using a suite of powerful, web-based calculators designed to streamline workflows and automate intricate mathematical modeling.

  3. LC/MS Method For Measurement In Human Plasma 2/17/2025

    According to the researchers, this plasma-based measurement has the potential to serve as a critical pharmacodynamic biomarker, facilitating the assessment of novel therapeutic approaches.

  4. Why Academic Centers Reach The Clinic Faster 10/29/2025

    In this segment of Cell & Gene Live, Designing Early Manufacturing For Long-Term Success In CGT, Raymond Luke, Senior Director of MSAT at Verismo Therapeutics and Todd Luman, Executive Director of Process and Product Development at Allogene, Luman explains that academic institutions often move faster in Phase 1 because many trials are investigator-initiated, allowing streamlined oversight and quicker regulatory engagement, though similar pathways for sponsor-led programs don’t yet exist in the U.S. or EU.

  5. Perfusion: Planning A Run 6/16/2025

    Learn about a logical approach for defining the operation of a perfusion run. We will break down the process using the three following steps: knowledge space, design space, and control space.

  6. DynaDrive Single-Use Bioreactors - One Reactor, Many Volumes 3/30/2026

    Single-use bioreactors with turndown ratios up to 20:1 enable facilities to operate across wide volume ranges within the same vessel, streamlining seed trains and reducing capital requirements for multi-product operations.

  7. An Inside Look At Umoja Biopharma And Bristol Myers Squibb's Cold Chains 11/13/2023

    Umoja's Co-Founder and CTO Ryan Crisman details The CLIMB and how an optimized cold chain is critical in the work being done there. Rookie Gleich, Global Head, Cell Therapy Logistics and Shipping Systems, BMS explains some of the cell therapy temperature standardization and why a wider temperature range may optimize the process.

  8. Developing Protocols For Controlled Rate Freezer Operations For iPSCs 4/15/2025

    In this segment of our Cell & Gene Live, Optimizing Storage Solutions for iPSCs, our expert panelists, Pratik Jaluria, Ph.D., SVP Technical Development Strategy at BlueRock Therapeutics, Bruno Marques, Ph.D. VP, Process and Product Development at Century Therapeutics, and Kate Rochlin, Ph.D., COO at IN8bio discuss why optimizing controlled rate freezer (CRF) protocols requires careful consideration of factors such as nucleation timing, cryoprotectant agents, vial type, fill volume, and freezer load configuration.

  9. A Conceptual Overview Of The BioSMB MCC Platform 6/7/2021

    In this video, our technology expert Jason Forte describes how the BioSMB system offers 3-5 fold increase in productivity, yielding up to 80% savings on chromatography resin costs with minimal disruption to the accepted ways of doing chromatography today.

  10. QC Sampling Post-Thaw And Scaling Up Automated Processes For iPSCs 4/15/2025

    During this portion of our Cell & Gene Live, Optimizing Storage Solutions for iPSCs, expert panelists, Pratik Jaluria, Ph.D., SVP Technical Development Strategy at BlueRock Therapeutics, Bruno Marques, Ph.D. VP, Process and Product Development at Century Therapeutics, and Kate Rochlin, Ph.D., COO at IN8bio continue the discussion on post-thaw processing, focusing on QC sampling and the challenges of scaling up automated thawing.