bio-techne White Papers

1. Targeting Macular Degeneration With Stem Cell Therapy 3/27/2024

   A novel stem-cell therapy based upon iPSC-derived RPE cell transplantation was conceptualized as a promising new treatment for AMD and other retinal diseases.

2. How Close Are We To The Clinic? 3/27/2024

   Organoids are offering new possibilities in therapeutic screening, regenerative medicine, and even organ transplantations. However, there are still several challenges to overcome.

3. Use Of Maurice CE-SDS In ICH Q6B-Based Biosimilar Comparability Exercises 11/23/2021

   The route to market for biosimilars places strong emphasis on the analytical and characterization techniques used to investigate the structure of the molecule and, importantly, side-by-side comparability. 

4. Validating Targets For Targeted Protein Degradation Using dTAG – A Comprehensive Workflow Solution 8/19/2021

   Degraders and the field of Targeted Protein Degradation offer a mechanistically differentiated way to modulate target proteins using small molecules. TAG degradation technology offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI). In this paper we present data to highlight a full dTAG workflow solution, from custom KI cell lines for a protein of interest, to different dTAG Degraders available for treatment and subsequent quantitative characterization using an automated high throughput western blotting platform, Simple Western.

5. Organoids: Ideal Model Systems For Disease And Drug Screening? 6/22/2021

   Successful organoid formation is dependent on many factors, all of which are crucial in fulfilling the potential of this powerful new tool for personalized medicine.

6. Producing Publication-Quality Data With Automated Western Blots 3/16/2021

   How Simple Western overcomes the challenges and pitfalls associated with traditional Western blots to produce publication-ready data that meets the highest standards of data integrity and rigor.

7. Markers And Methods To Verify Mesenchymal Stem Cell Identity, Potency, And Quality 2/10/2021

   This white paper defines and discusses the evolution of MSC nomenclature and provides a detailed description of MSC markers and how they may vary by tissue source and species. Learn how to standardize MSC characterization by selecting markers for isolation, characterization, and validation.

8. Simple Western Advances Cutting-Edge Duchenne Muscular Dystrophy Research 2/4/2021

   Duchenne Muscular Dystrophy (DMD) is a severe genetic disease characterized by the progressive breakdown of skeletal and cardiac muscles, resulting in weakness, loss of cardiac function and premature death. The cause of DMD is frameshift mutations to dystrophin, a gene responsible for linking the actin network to transmembrane components of the dystrophin-associated glycoprotein complex (DGC). Dystrophin’s large molecular weight is no problem for Simple Western, a capillary-based immunoassay platform from ProteinSimple.

9. Simple Western With Jess Uncovers Possible New Strategy To Prevent And Treat COVID-19 2/4/2021

   As the global death toll from the COVID-19 pandemic approaches 1 million, the scientific community has jumped into high gear to understand and treat SARS-CoV-2 infection. It is understood that SARS-CoV-2 entry into host cells involves the binding of the viral spike protein to the human ACE2 receptor. Read more about how Simple Western, the automated Western blot platform from ProteinSimple, can detect and quantify ACE2 and the associated protease TMPRSS2 in human cells.

10. Micro-Flow Imaging Enables Cutting Edge Biopharmaceutical Research 1/26/2021

    Micro-Flow Imaging (MFI), a system to analyze protein aggregates and other subvisible particles in your samples and can assess the stability of antibody-based biotherapeutics in response to stress