FEATURED ARTICLES

• Quality Versus Quantity In T-Cell Production

  Technological advances have made it possible to produce high-quality T cells at scale, providing a boon for T-cell manufacturing.

• iPSC Expansion In A Cell Expansion System's Small Bioreactor

  Explore how using a flexible, automated system can help expand iPSCs faster than traditional culture methods.

• Cell Expansion System Supports Proliferation Of Regulatory T-Cells

  This study showcases a cell expansion system that is providing T-cells with an ideal environment for growth, efficient in expanding many cells quickly, and enhancing regulatory T-cell characteristics.

• HEK293T Cell Expansion Protocol Using A Hollow-Fiber Bioreactor System

  Explore the use of a hollow-fiber bioreactor (HFB) system for the automated expansion of HEK293T cells and a protocol used to help users of the system.

• Study Of Small Bioreactor Expansion Kinetics During Expansion Protocol

  Mesenchymal stem cells have been used to show equivalent expansion kinetics during a 7-day expansion protocol on both the small and standard bioreactors revealing efficiency differences.

• Quintessential Role Of Apheresis In Gene-Modified T-Cell Therapy

  Learn more about process standardization and comprehensive quality management programs as it relates to leukapheresis and cell therapy manufacturers.

• Choose The Right Bioreactor Size For Your Cell Expansion

  Compare expansion parameters when adherent cells are cultured on the small and standard bioreactors using a hollow-fiber bioreactor platform.

• Optimized Fill And Finish To Limit DMSO’s Negative Impact On T Cells

  In order to improve the existing cryopreservation paradigm, operators must consider fill/finish and cryopreservation techniques that streamline processing steps and minimize cells’ exposure to DMSO.

• Matters of Scale: Centralized Vs. Decentralized Manufacturing

  In advanced therapy manufacturing, reducing human intervention and manual processes is critical to optimizing manufacturing paradigms, simplifying processes, and improving quality and efficacy.

• Elevate Your T-Cell Manufacturing Process

  Today automation and next-generation bioreactors are two prime areas of innovation for enhancing cell manufacturing. Here we delve into some ways these innovations could improve T-cell based therapy production.

• The Monoculture Of Cord-Blood-Derived CD34+ Cells

  Explore an 8-day expansion of a 2 × 10 positively selected CD34⁺ cell inoculum from 3 donor lineages, and the results proving the automated monoculture protocol can support that expansion with minimal lymphocyte residual.

• Incorporating Automation Into Your Fill And Finish Procedure

  Incorporate automation into fill and finish procedures and learn more about the impact of automation on production costs and product quality.

• Cell Therapy’s Live Analytical Challenges

  Learn about analytical science tools that can be employed to take cell and gene therapy to the next level.

• Achieve Efficiency And Quality In Cell Therapy Manufacturing

  Enabling automation, reducing manual steps, and implementing standard procedures is key to success in cell therapy manufacturing.

• Large‑Scale Expansion And Characterization Of CD3+ T‑Cells

  We demonstrate a versatile platform for the expansion of T-cells that that reduces time and resources needed to produce a therapeutic dose.

• Top Three Reasons Why Automated Data Acquisition Is Critical To Fill And Finish Quality

  Learn how data automation facilitates cGMP compliance and product quality by giving users access to accurate, high-fidelity data to optimize processes and operations.

• Automating Fill And Finish: Five Steps For Scaling Success

  Discover how a solution can help therapeutic providers gain tighter control of their processes and deliver higher-performing treatments compared to manual methods.