Newsletter | November 18, 2025

11.18.25 -- What Can The Tech Sector's 'Minimally Viable' Concept Teach Biopharma?

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Webinar: Unpacking pDNA processes: Capacity, complexity, and cutting-edge solutions

Plasmid DNA demand is exploding—driven by breakthroughs in gene therapy, mRNA vaccines, and cell therapies. But scaling production fast and flawlessly is no easy feat. Join experts from Cytiva, Bionova, and industry leaders as they reveal how flexible facilities, smart process innovations, and real-world lessons can help you scale pDNA manufacturing efficiently and stay ahead of growing therapeutic demand. Click here to learn more.

FOCUS ON MANUFACTURING

What Can The Tech Sector's 'Minimally Viable' Concept Teach Biopharma?

Deciding what is good enough to get started can support the mindset of building something without sacrificing quality, functionality, or safety.

Addressing The Challenges In Lentivirus Harvest Clarification

Traditional depth filtration struggles with lentiviral harvest clarification, leading to low yields and high costs. However, single-use centrifugation offers a promising alternative.

Comparing Methods To Yield Clinical-Scale Expansion Of Gamma Delta T Cells

Data from the use of two distinct methods to generate billions of gamma delta T cells from peripheral blood mononuclear cells (PBMCs) is compared.

COGs Process Economics For Autologous Cell Therapy

Analyze the cost distribution over time for autologous CAR T therapy manufacturing using process economics and additional insights. Discover how cell therapy manufacturers can combat these costs.

Analytics: A Referee For The Tug-Of-War Between MSC-EVs' Nature And Nurture

Like a referee in a contest, advanced analytical methods are essential to mediate the push and pull of different factors influencing therapeutic efficacy.

Maintain Sterility And Ease In CGT Development, Including Cryopreservation

Sterile connectors streamline cell and gene therapy processes while maintaining sterility. By withstanding extreme temperatures and cryoprotectants, they can ensure product viability during cryopreservation.

Minimizing Residue Build-Up In Cleanrooms

Residues from cleaning agents can pose significant risks to cleanroom operations. Learn about residue management, measurement techniques, and best practices to ensure compliance and product safety.

Centrifuge Bioprocess Bags: Closed, Sterile Cell Harvest, And Separation

Explore single-use centrifuge bags designed for efficient cell harvest and separation that offer robust film technology, full traceability, and seamless integration with Sorvall BIOS 16 systems.

Accelerating Cell Therapy Through Improved Fluid Dynamics Characterization

Cell and gene therapies face cost and scalability hurdles, but new platforms can improve efficiency, consistency, and cell quality, helping make these treatments more commercially viable.

Freeze, Thaw, And Expand: Chemically Defined T Cell Workflow

A chemically defined T cell workflow improves reproducibility and supports robust expansion in both static and bioreactor scale-up systems, while allowing for the elimination of the post-thaw wash step.

Liquid Biopsy-Based Detection Of PIK3CA Mutations From cfDNA

Assimilate how ultra-sensitive digital PCR workflows use an innovative system to enable precise detection of rare PIK3CA mutations in cfDNA and advance personalized cancer treatment.

Advancing Non-Viral Gene Editing With Post-Electroporation Performance

Non-viral gene editing is a powerful method for cell therapy. Learn how to address key challenges like cell viability and thermal damage with an innovative approach designed to improve performance.

Embarking On A Successful Cleanroom Project: Conception To Delivery

Uncover how you can obtain comprehensive, customized solutions for cleanroom projects that help you ensure regulatory compliance and optimize operational efficiency.

MANUFACTURING SOLUTIONS

Resin Guide: A Trusted Resource for Biotherapeutic Purification - Bio-Rad Laboratories

AAV Manufacturing With Advanced Polymer And Lipid Technologies - Mirus Bio

Purpose-Built Just For CGT - InspiroGene

Breaking Productivity Barriers In Upstream Bioprocessing - Repligen

Proven Vial Containment That Scales From R&D To Commercial - West Pharmaceutical Services, Inc.

Complete Solutions For Every Step Of Pharmaceutical Development - Cytiva

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