AAV Manufacturing: Increase AAV Titers And Percent Full Capsids Through Advanced Polymer And Lipid Technologies
By combining purpose-built polymers and lipids, animal-origin-free reagents seamlessly blend into the AAV manufacturing process during transfection to dramatically increase AAV titers.
Increase AAV Titers and Percent Full Capsids Through Advanced Polymer and Lipid Technologies
Harnessing recombinant adeno-associated virus (AAV) as vectors for cell and gene therapy requires robust upstream manufacturing processes that are reproducible, scalable, and quality-controlled. By combining purpose-built polymers and lipids, Mirus Bio has developed animal origin free reagents that seamlessly blend into the AAV manufacturing process at the time of transfection to dramatically increase AAV titers. With scalable, consistent performance, the TransIT-VirusGEN® Transfection Reagent paired with the RevIT™ AAV Enhancer will improve the efficiency and output of your AAV production platforms, all while driving down the cost per dose.
Adeno-Associated Viral Vector Production
Improve AAV productivity and critical process parameters with a best-in-class transfection reagent and enhancer platform to ensure success in your AAV viral vector manufacturing:
- Higher AAV Titers
- Increase Percentage of Full Capsids
- Consistent and Scalable
- Top-of-Industry Support
How to Scale Your AAV Manufacturing Process
Scaling your AAV manufacturing process can be a complex endeavor, but with the right tools and support, it becomes a streamlined and efficient operation. Mirus Bio provides industry-leading solutions to enhance every step of your AAV production, ensuring high yields and consistent results. Here’s how our products and support can elevate your AAV platform:
AAV Transfection Reagent
Mirus Bio’s transfection reagents are designed to deliver higher titers across all AAV serotypes, media, and HEK cell lines. Our innovative formulations ensure optimal gene delivery, maximizing your output and efficiency. Our reagents provide reliable, high-performance results every time over polymer only reagents.
AAV Enhancers
Increase your AAV titer up to 4X with RevIT™ AAV Enhancer. RevIT is compatible with multiple serotypes, media, and HEK cell lines, making it an easy and effective addition to your workflow. By incorporating RevIT into your process, you can achieve significantly higher yields with minimal effort.
Overcoming AAV Challenges
Utilize the most responsive and dedicated support team in the industry. Our team of transfection experts is committed to helping you succeed.
A dedicated team of Field Application Scientists (FAS) can help you plan your experiments, review your data, and provide on-site assistance, saving you time and resources.
Personalized support to optimize your processes, reducing the risk of bioreactor issues, wasted materials, lost time, or wasted budget.
Scaling Up with GMP Manufacturing
Your drug assets require the support of GMP and ISO-compliant material, designed to enable the commercial-scale production. Choose reagents and enhancers that maintain their results from the smallest shake flasks to the largest bioreactors.
Through longer transfection complex formation times, your upstream processing team can easily scale up to larger bioreactors with products designed to reduce risks and cut costs.
Confidently scale your AAV production from the lab to commercial manufacturing.
Transfection Adoption Partnership
Join our Transfection Adoption Partnership (TAP) program to gain access to exclusive benefits, including:
- Preferred pricing
- Priority white glove service
- Thought leadership opportunities
Partner AAV manufacturing companies receive tailored support to enhance their transfection processes, ensuring they remain at the forefront of AAV manufacturing innovation.
Rev Up Your AAV Genome Production
Take the first steps towards increasing your transfection efficiency by reading the free white paper on how the RevIT AAV Enhancer can be applied to your workflow.
How to Cut Costs:
2X the Number of Doses from a 200L Bioreactor
6.1X increase in titer over Polymer P
White Paper Preview:
See how TransIT-VirusGEN® + RevIT™ compare against other transfection reagents in both titer and percent full capsids.
VirusGEN® is the only transfection system to incorporate proprietary polymer and lipid technology – which enables both high efficiency and productivity.
~2X increase in full capsids vs Polymer F
Work with a team of transfection experts to achieve upstream improvements, saving on bioreactor runs, capital commitments and more.
AAV Manufacturing Costs
Compare transfection reagents and cut your cost per dose in half. See how much your lab can save when scaling your viral production with the transfection calculator.
Labs and manufacturers save via:
- Fewer bioreactor runs
- Less pDNA required
- Longer complex formulation windows
- 8 other variables