What Are MSCs And How Are They Used?

Mesenchymal stem/stromal cells (MSCs) are a crucial cell type in regenerative medicine, capable of differentiating into bone, cartilage, and fat cells. Understanding their defining characteristics is essential, as the International Society for Cell and Gene Therapy (ISCT) requires specific criteria—including multipotency and surface marker expression—for proper classification.

MSCs can be derived from various sources, such as bone marrow, adipose tissue, and birth tissues, with each source offering unique benefits and limitations regarding invasiveness and cell quality. Beyond their traditional use in addressing blood disorders, these cells are now being investigated for their immunomodulatory and anti-inflammatory potential in a wide range of conditions. Current research highlights applications in treating kidney and liver diseases, neurological disorders, and in cartilage tissue engineering. For lab managers, staying current on MSC developments is key to making informed decisions on research projects, resource allocation, and maintaining compliance.

Dive deeper into the world of MSCs, their applications, and the essential considerations for your lab.