The Science of Selection: Choosing The Right Hollow Fiber Filter

By Philip Yuen, Ph.D., Repligen

Tangential flow filtration (TFF) using hollow fiber (HF) membranes is a foundational technology in bioprocessing and biopharmaceutical manufacturing, especially in downstream operations. This method is essential for ultrafiltration and diafiltration (UF/DF), where it facilitates the efficient concentration and buffer exchange of liquid feedstock. Unlike normal flow filtration (NFF), HF-based TFF operates in a cross-flow manner that significantly reduces membrane fouling. This not only improves throughput but also enhances the reproducibility and consistency of results across different production scales. The gentle nature of TFF ensures that sensitive biological products are preserved during processing, which makes it a preferred choice for high-value therapeutics.

As the demand for scalable, high-performance filtration solutions continues to grow. Integrating HF TFF into your downstream workflows can be a strategic move toward optimizing product quality and process efficiency.

Explore how hollow fiber TFF can elevate your bioprocessing operations.