Newsletter | June 25, 2025

06.25.25 -- The Promise Of Focused Ultrasound For AAV Gene Therapy Delivery

SPONSOR

Webinar: CRISPR meets LNPs: A new era in cell and gene therapies

Join industry experts as they present new data demonstrating the potential of CRISPR-LNPs for multiplex gene editing in primary human T cells. Explore how non-viral delivery platforms like LNPs could reshape the future of cell and gene therapy—from manufacturing and regulation to clinical translation. Click here to learn more.

FOCUS ON TRANSLATIONAL RESEARCH

The Promise Of Focused Ultrasound For AAV Gene Therapy Delivery

Dr. Bernie Owusu-Yaw, a research fellow at Brigham and Women’s Hospital and Harvard Medical School, is pioneering a promising gene therapy approach that combines focused ultrasound with novel AAV capsids to safely and effectively deliver therapeutics across the blood-brain barrier, offering new hope for treating challenging neurodegenerative diseases.

CD73: A Team Player Caught In The "AKT" Of Wound Healing And Cell Survival Via MSC Exosomes?

CD73, found in MSC exosomes, is a key player in tissue repair. Discover how this protein contributes to cell survival and the intricate process of wound healing.

Navigating Cell Therapy Process Development

Equip yourself with the knowledge necessary to make well-informed decisions by exploring the main challenges and considerations inherent in cell therapy process development.

Assigning IR Absorption Bands For RNA Building Blocks Using MMS

Explore the power of Microfluidic Modulation Spectroscopy (MMS) in identifying RNA base signatures through a study that analyzes vibrational modes of A, G, C, and U.

Viruses And Viral Vectors, Are They Different?

Learn how effective disinfection solutions can ensure safety in pharmaceutical manufacturing by managing viral contaminants and enhancing patient protection.

Transcriptome Profiling Of Cerebellar Organoids In Dynamic Conditions

This method for generating human iPSC-derived cerebellar organoids allows for reproducible and large-scale production of organoids that recapitulate key features of cerebellar development.

AI-Driven Spatial Proteomics Reveals Immune Diversity In 4T1 Tumor Model

AI-driven spatial proteomics in 4T1 murine tumors reveals diverse immune populations, and pro-tumorigenic environments, advancing insights into tumor progression and therapeutic resistance.

Dissecting Cellular Composition Using Single-Cell Multiomics

Hear from Dr. Fabio Luciani, Professor and Senior Researcher in Systems Immunology at the School of Medical Sciences and the Kirby Institute at UNSW Sydney about his recent research.

Gene Therapy Solutions: From Discovery To Commercialization

Learn how advanced technologies and methodologies are driving progress in gene therapy, enabling safer and more effective treatments for rare and complex diseases.

Exploring Electroporation: Genetic Diseases

This collection of articles explores the role of genetic engineering in understanding, preventing, and treating genetic diseases.

Guidelines For Comparing SYBR Green Master Mixes

Explore a protocol for comparing the performance of Applied Biosystems PowerTrack SYBR Green Master Mix with other master mixes in PCR applications.

SPONSOR

Explore the evolving role of exosomes and extracellular vesicles (EVs) at the next Cell & Gene Live. Chief Editor Erin Harris moderates a discussion with Capricor’s Linda Marbán and Aegle’s Dr. Gloria Matthews on clinical and commercial advances, including applications in rare and cardiovascular diseases. Gain insights into the future of exosome-based therapies from leaders driving innovation across R&D, manufacturing, and commercialization.

TRANSLATIONAL RESEARCH SOLUTIONS

gentleMACS Octo Dissociator With Heaters - Miltenyi Biotec

AAV Viral Titer And Empty-Full Capsid Ratio Measurement With A Single Assay - Bio-Rad Laboratories, Inc.

Introduction To An End-To-End Clinical Data Science Platform - Revvity Signals Software, Inc.

Connect With Cell & Gene: