Assigning IR Absorption Bands For RNA Building Blocks Using Microfluidic Modulation Spectroscopy

Microfluidic Modulation Spectroscopy (MMS) is used in this study to identify and analyze the distinctive absorption peaks of RNA bases including adenine (A), guanine (G), cytosine (C), and uracil (U). MMS makes it possible to do a thorough investigation of the molecular interactions of these RNA building blocks by utilizing the particular vibrational modes that correspond to certain functional groups within these bases.
The signature peaks, which are produced by the vibrational responses of C-H, N-H, and C=O bonds, show the base-specific electronic environments and how molecular interactions like RNA base pairing and stacking affect them. In addition to laying the groundwork for the spectral characteristics of each RNA base, this study also looks at how spectral variations might be used to better understand the structural and functional facets of RNAs.
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