Scalable Manufacturing Of MSC-Derived EVs

Extracellular Vesicles (EVs) are a growing segment of Regenerative Medicine and are particularly attractive as a therapeutic model, utilizing a non-viable biologically active agent. In her presentation at ISEV, Taby Ahsan discusses considerations for the manufacturing of EVs derived from mesenchymal stem/stromal cells, including the tissue source, the cell state, and process parameters. She also discusses the importance of evaluating EV productivity in manufacturing processes, highlighting limitations and advantages of 2D and 3D bioreactor production.